Melanoma

Principal investigators

Cutaneous melanoma, a tumor originating from melanocytes residing in the skin, is the most deadly form of skin cancer. The melanoma research group primarily studies the genetics of melanoma predisposition, development and progression. Methods employed include various genome-wide technologies, cell-based assays and organotypic culture models to identify melanoma-related genetic alterations and understand their significance in tumorigenesis.

Key Publications

  1. Demenais et al., Consortium. Association of MC1R variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: a GenoMEL study. J Natl Cancer Inst. 2010 Oct 20;102(20):1568-83.
  2. Bishop et al., Genome-wide association study identifies three loci associated with melanoma risk. Nat Genet. 2009 Aug;41(8):920-5.
  3. van Doorn et al., . Absence of germline epimutation of the CDKN2A gene in familial melanoma. J Invest Dermatol. 2009 Mar;129(3):781-4.
  4. Goldstein et al., Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents. J Med Genet. 2007 Feb;44(2):99-106.
  5. Kamb et al., A cell cycle regulator potentially involved in genesis of many tumor types. Science. 1994 Apr 15;264(5157):436-40.