Dr. L.C. (Liesbeth) de Wreede

I am an assistant professor in medical statistics, specialising in survival analysis. I collaborate extensively with clinicians and researchers in the field of hematopoietic (mainly allogeneic) stem cell transplantation, both inside and outside LUMC (EBMT, DKMS, HOVON, CIBMTR). In addition, I supervise PhD candidates and postdocs, both in developing and investigating statistical methodology and in applying complex models in clinical studies. I teach as well, mainly to students in Medicine and Biomedical Sciences. Together with Hein Putter, I organise the course Advanced Survival Analysis.
I have studied Mathematics, and Greek and Latin Languages and Cultures at Leiden University. Afterwards, I have defended a PhD thesis on a topic from history of mathematics at Utrecht University. I have been working at LUMC since 2006.

My scientific research is motivated by problems which occur in the analysis of clinical data where different relevant events play a role. This has led to a series of publications about competing risks and multi-state models, both in the methodological area and in new applications. In particular, I am interested in the combination of multi-state models and relative survival. Besides, I study different missing data problems (imputation strategies, haplotype reconstruction, missing data in the context of prediction models, coarsened observations). These models are usually applied in studies in the domain of cancer (esp. hematological cancers), often with an immunological component. In the past year, I have worked on a project about excess mortality in the Netherlands, 2020-2021, funded by ZonMW. At the moment, I am PI of another ZonMW funded project about modelling for pandemic preparedness.