- Regenerative medicine
- Cerebral ischemia
- Stem cells
- Molecular imaging
- In vivo MRI and optical imaging
Prof. Dr. Mathias Hoehn received his PhD in biophysics from the University of Regensburg, Germany, in 1983, after studies of physics and biology at the University of Regensburg, University of Colorado at Boulder and University of Massachussetts in Amherst. Scientific focus of that period was the structure function relationship of heme proteins using ESR/ENDOR techniques. He went to University of California in San Diego as a senior scientist for optical studies on photosynthesis, from where he accepted a position at the Medical School of the RWTH in Aachen, Germany, as head of the MRI imaging lab in the Physiology Dept. In 1987 he set up the In-vivo-NMR Laboratory at the Max Planck Institute for Neurological Research (now MPI for Metabolism Research),the first major in vivo high field MRI lab in the country dedicated to small animal neuroscience studies. In this lab, continuous innovations on high field MRI included the first installation of an 11.7Tesla ultrahigh field MRI system, dedicated to molecular imaging. In 1996, the Medical Faculty of the University at Cologne accepted his habilitation, soon to be followed by the appointed title of professor of experimental neurology. Today, he is leading the Independent Research Group, the In-vivo-NMR Laboratory, at the Max Planck Institute for Metabolism Research in Cologne. After a sabbatical with Prof. C. Löwik at the Endocrinology Dept of the LUMC in 2010, he was appointed Visiting Professor at LUMC in 2013. As a founding member of the European Society for Molecular Imaging in 2004, he has taken over the presidentship of the Society in 2016.
His present scientific interest is focused on stem cell mediated regeneration of brain diseases, with particular attention to stroke. For this purpose, he applies multimodal molecular imaging in conjunction with imaging reporters of gene expression where both the fate mapping of the stem cell graft as well as the characterization of the brain lesion, and the brain’s structural and functional network are investigated and correlated with electrophysiological and behavioural methods. Growing interest is dedicated to the role of inflammation after stroke and the mutual interaction of inflammatory cells and (grafted) stem cells.
Leids Universitair Medisch Centrum
2333 ZA Leiden
2300 RC Leiden