Dr. Rico Derks

Vakgebied(en)

  • Metabolomics
  • Data analysis

Introductie

Rico Derks studied at the Vrije Universiteit in Amsterdam (The Netherlands) and recieved his M.Sc. in analytical chemistry. His Ph.D. he obtained in 2006, also at the Vrije Universiteit, working on the coupling of biochemical assays to mass spectrometry for detection and indentification of bioactive compounds. After a post-doctoral position at the Department of Parasitology (LUMC, Leiden, The Netherlands) he continued as a senior researcher at the Center for Proteomics and Metabolomics (LUMC) working in the field of untargeted and targeted metabolomics.


Research interests

 

  • Sample preparation in bioanalysis, including conventional approaches and modern/miniaturized techniques;
  • Ultra-high pressure liquid chromatography
  • Mass spectrometry (QqQ, TOF/MS, QqTOF)
  • Metabolomics (profiling, targeted quantitative profiling)

 


Publications

Plasma metabolic profiling after cortical spreading depression in a transgenic mouse model of hemiplegic migraine by capillary electrophoresis mass spectrometry,Shyti Reinald, Kohler Isabelle, Schoenmaker Bart, Derks Rico J. E., Ferrari Michel D., Tolner Else A., Mayboroda Oleg A., van den Maagdenberg Arn M. J. M.,MOLECULAR BIOSYSTEMS,2015,11,1462-1471

Exploratory analysis of urinary tract infection using a GC-APCI-MS platform,Pacchiarotta Tiziana, Derks Rico J., Nevedomskaya Ekaterina, van der Starre Willize, van Dissel Jaap, Deelder Andre, Mayboroda Oleg A.,ANALYST,2015,140,2834-2841

Effect of Suboptimal Sampling and Handling Conditions on Urinary Metabolic Profiles,Morello Judit, Nevedomskaya Ekaterina, Pacchiarotta Tiziana, Schoemaker Bart, Derks Rico, Voet Nicoline B. M., Meissner Axel, Deelder Andre M., van Engelen Baziel G. M., Mayboroda Oleg A.,CHROMATOGRAPHIA,2015,78,429-434

Detection and Structural Elucidation of Esterified Oxylipids in Human Synovial Fluid by Electrospray Ionization-Fourier Transform Ion-Cyclotron Mass Spectrometry and Liquid Chromatography-Ion Trap-MS3: Detection of Esterified Hydroxylated Docosapentaenoic Acid Containing Phospholipids,Jonasdottir Hulda S., Nicolardi Simone, Jonker Willem, Derks Rico, Palmblad Magnus, Ioan-Facsinay Andreea, Toes Rene, van der Burgt Yuri E. M., Deelder Andre M., Mayboroda Oleg A., Giera Martin,ANALYTICAL CHEMISTRY,2013,85,6003-6010

Coupling porous sheathless interface MS with transient-ITP in neutral capillaries for improved sensitivity in glycopeptide analysis,Heemskerk AAM, Wuhrer M, Busnel JM, Koeleman CAM, Selman MHJ, Vidarsson G, Kapur R, Schoenmaker B, Derks RJE, Deelder AM, Mayboroda OA,ELECTROPHORESIS,2013,34,383-387

Online spectral library for GC-atmospheric pressure chemical ionization-ToF MS,Pacchiarotta Tiziana, Derks Rico J. E., Hurtado-Fernandez Elena, van Bezooijen Pauline, Henneman Alex, Schiewek Ralf, Fernandez-Gutierrez Alberto, Carrasco-Pancorbo Alegria, Deelder Andre M., Mayboroda Oleg A.,BIOANALYSIS,2013,5,1515-1525

Fc specific IgG glycosylation profiling by robust nano-reverse phase HPLC-MS using a sheath-flow ESI sprayer interface,2012,75

Standardized and automated solid-phase extraction procedures for high-throughput proteomics of body fluids,Bladergroen MR, Derks RJE, Nicolardi S, de Visser B, van Berloo S, van der Burgt YEM, Deelder AM,JOURNAL OF PROTEOMICS,2012,77,144-153

Fibrinogen alpha chain O-glycopeptides as possible markers of urinary tract infection,Pacchiarotta T, Hensbergen PJ, Wuhrer M, van Nieuwkoop C, Nevedomskaya E, Derks RJE, Schoenmaker B, Koeleman CAM, van Dissel J, Deelder AM, Mayboroda OA,JOURNAL OF PROTEOMICS,2012,75,1067-1073

Ultra-Low Flow Electrospray Ionization-Mass Spectrometry for Improved Ionization Efficiency in Phosphoproteomics,Heemskerk AAM, Busnel JM, Schoenmaker B, Derks RJE, Klychnikov O, Hensbergen PJ, Deelder AM, Mayboroda OA,ANALYTICAL CHEMISTRY,2012,84,4552-4559

Metabolic profiling of mouse cerebrospinal fluid by sheathless CE-MS,Ramautar R, Shyti R, Schoenmaker B, de Groote L, Derks RJE, Ferrari MD, van den Maagdenberg AMJM, Deelder AM, Mayboroda OA,ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2012,404,2895-2900

Derivatization of the tricarboxylic acid cycle intermediates and analysis by online solid-phase extraction-liquid chromatography-mass spectrometry with positive-ion electrospray ionization,Kloos D, Derks RJE, Wijtmans M, Lingeman H, Mayboroda OA, Deelder AM, Niessen WMA, Giera M,JOURNAL OF CHROMATOGRAPHY A,2012,1232,19-26

Fc specific IgG glycosylation profiling by robust nano-reverse phase HPLC-MS using a sheath-flow ESI sprayer interface,Selman MHJ, Derks RJE, Bondt A, Palmblad M, Schoenmaker B, Koeleman CAM, van de Geijn FE, Dolhain RJEM, Deelder AM, Wuhrer M,JOURNAL OF PROTEOMICS,2012,75,1318-1329

Ultra high performance liquid chromatography-time of flight mass spectrometry for analysis of avocado fruit metabolites: Method evaluation and applicability to the analysis of ripening degrees,Hurtado-Fernandez Elena, Pacchiarotta Tiziana, Gomez-Romero Maria, Schoenmaker Bart, Derks Rico, Deelder Andre M., Mayboroda Oleg A., Carrasco-Pancorbo Alegria, Fernandez-Gutierrez Alberto,JOURNAL OF CHROMATOGRAPHY A,2011,1218,7723-7738

The feasibility of MS and advanced data processing for monitoring Schistosoma mansoni infection,Balog CIA, Alexandrov T, Derks RJ, Hensbergen PJ, van Dam GJ, Tukahebwa EM, Kabatereine NB, Thiele H, Vennervald BJ, Mayboroda OA, Deelder AM,PROTEOMICS CLINICAL APPLICATIONS,2010,4,499-510

CE-MS for Metabolic Profiling of Volume-Limited Urine Samples: Application to Accelerated Aging TTD Mice,Nevedomskaya E, Ramautar R, Derks R, Westbroek I, Zondag G, van der Pluijm I, Deelder AM, Mayboroda OA,JOURNAL OF PROTEOME RESEARCH,2010,9,4869-4874

Improving mass measurement accuracy in mass spectrometry based proteomics by combining open source tools for chromatographic alignment and internal calibration,Palmblad M, van der Burgt YEM, Dalebout H, Derks RJE, Schoenmaker B, Deelder AM,JOURNAL OF PROTEOMICS,2009,72,722-724

Explorative Analysis of Urine by Capillary Electrophoresis-Mass Spectrometry in Chronic Patients with Complex Regional Pain Syndrome,Ramautar R, van der Plas AA, Nevedomskaya E, Derks RJE, Somsen GW, de Jong GJ, van Hilten JJ, Deelder AM, Mayboroda OA,JOURNAL OF PROTEOME RESEARCH,2009,8,5559-5567

Alignment of capillary electrophoresis-mass spectrometry datasets using accurate mass information,Nevedomskaya E, Derks R, Deelder AM, Mayboroda OA, Palmblad M,ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2009,395,2527-2533

Novel Automated Biomarker Discovery Work Flow for Urinary Peptidomics,Balog CI, Hensbergen PJ, Derks R, Verweij JJ, van Dam GJ, Vennervald BJ, Deelder AM, Mayboroda OA,CLINICAL CHEMISTRY,2009,55,117-125

Capillary electrophoresis-time of flight-mass spectrometry using noncovalently bilayer-coated capillaries for the analysis of amino acids in human urine,Ramautar R, Mayboroda OA, Derks RJE, van Nieuwkoop C, van Dissel JT, Sornsen GW, Deelder AM, de Jong GJ,ELECTROPHORESIS,2008,29

Amino acid profiling in urine by capillary zone electrophoresis - mass spectrometry,Mayboroda OA, Neususs C, Pelzing M, Zurek G, Derks R, Meulenbelt I, Kloppenburg M, Slagboom EP, Deelder AM,JOURNAL OF CHROMATOGRAPHY A,2007,1159


Contactgegevens

Leids Universitair Medisch Centrum
Gebouw 2
Kamer S3-48

Einthovenweg 20
2333 ZC Leiden
Tel: +31 71 5269390

Postzone S3
Postbus 9600
2300 RC Leiden

E-mail: R.J.E.Derks@lumc.nl