Dr. Noortje de Haan

Postdoctoral researcher

Vakgebied(en)

  • Glycomics and glycoproteomics

Introductie

Noortje de Haan is conducting her post-doctoral research at the Center for Proteomics and Metabolomics at the Leiden University Medical Center, The Netherlands. She obtained her MSc degree in Pharmaceutical Sciences at the VU University Amsterdam, The Netherlands, with a focus on biomarker research and clinical chemical analysis. She received her PhD (cum laude) at the Leiden University Medical Center, under the supervision of prof. Manfred Wuhrer, on the development and application of various mass spectrometry-based methods for the analysis of (antibody) glycosylation. Noortje’s enthusiasm for glycoproteomic-related research started early in her scientific career and this remains a key drive in her current work. She is interested in the development of mass spectrometric methods and data analysis protocols for addressing clinical research questions.


Curriculum Vitae

Since October 2018: Postdoctoral researcher at the Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, The Netherlands.

2014-2018 PhD-student at the Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, The Netherlands. Thesis: Clinical Glycomics of Antibodies by Mass Spectrometry

2012-2014 Master program Biomarkers and Clinical Chemical Analysis at the VU university, Amsterdam, The Netherlands

2012-2014 MSc+ Program Analytical Chemistry, at TI-COAST, Amsterdam, The Netherlands

2009-2012 Bachelor program Pharmaceutical Sciences at the VU university, Amsterdam, The Netherlands 


Publications

First author papers

Linkage-Specific Sialic Acid Derivatization for MALDI-TOF-MS Profiling of IgG Glycopeptides
N de Haan, KR Reiding, M Haberger, D Reusch, D Falck, M Wuhrer
Analytical Chemistry 87 (16), 8284-8291, 2015

Changes in Healthy Human IgG Fc-Glycosylation After Birth and During Early Childhood
N de Haan, KR Reiding, G Driessen, M van der Burg, M Wuhrer
Journal of Proteome Research 15 (6), 1853-1861, 2016

The N-glycosylation of Mouse Immunoglobulin G (IgG)-Fragment Crystallizable Differs Between IgG Subclasses and Strains
N de Haan, KR Reiding, J Krištić, AL Hipgrave Ederveen, G Lauc, M Wuhrer
Frontiers in immunology 8, 608, 2017

Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases
M Šimurina*, N de Haan*, F Vučković*, NA Kennedy, J Štambuk, D Falck, I Trbojević-Akmačić, F Clerc, Ge Razdorov, A Khon, A Latiano, R D'Incà, S Danese, S Targan, C Landers, M Dubinsky, DPB McGovern, V Annese, M Wuhrer, G Lauc
*contributed equally
Gastroenterology 154, 1320-1333, 2018

IgG Fc Glycosylation After Hematopoietic Stem Cell Transplantation is Dissimilar to Donor Profiles
N de Haan, MJD van Tol, GJ Driessen, M Wuhrer, AC Lankester
Frontiers in Immunology 9, 1238, 2018

Differences in IgG Fc Glycosylation Are Associated with Outcome of Pediatric Meningococcal Sepsis
N de Haan, NP Boeddha, E Ekinci, KR Reiding, M Emonts, JA Hazelzet, M Wuhrer, GJ Driessen
mBio 9 (3), 2018

Comparative Glycomics of Immunoglobulin A and G from Saliva and Plasma Reveals Biomarker Potential
R Plomp*, N de Haan*, A Bondt, J Murli, V Dotz, M Wuhrer
*contributed equally
Frontiers in Immunology 9, 2436, 2018

Highly Sensitive CE-ESI-MS Analysis of N-glycans from Complex Biological Samples
GSM Kammeijer*,N de Haan*, P Mohaupt, S Wagt, M Filius, J Nouta, D Falck, M Wuhrer
*contributed equally
Nature Communications 2019, in press

Co-authorships

Linkage-Specific in situ Sialic Acid Derivatization for N-glycan Mass Spectrometry Imaging of Formalin-Fixed Paraffin-Embedded Tissues
S Holst*, B Heijs*, N de Haan, RJM van Zeijl, IH Briaire-de Bruijn, GW van Pelt, AS Mehta, PM Angel, WE Mesker, RA Tollenaar, RR Drake, JVMG Bovée, LA McDonnell, M Wuhrer
*contributed equally
Analytical Chemistry 88 (11), 5904-5913, 2016

LaCyTools: A Targeted Liquid Chromatography–Mass Spectrometry Data Processing Package for Relative Quantitation of Glycopeptides
BC Jansen, D Falck, N de Haan, AL Hipgrave Ederveen, G Razdorov, G Lauc, M Wuhrer
Journal of Proteome Research 15 (7), 2198-2210, 2016

Recent Advances in Clinical Glycoproteomics of Immunoglobulins (Igs)
R Plomp, A Bondt, N de Haan, Y Rombouts, M Wuhrer
Molecular & Cellular Proteomics 15 (7), 2217-2228, 2016

Patients with IgG1-Anti-Red Blood Cell Autoantibodies Show Aberrant Fc-Glycosylation
ME Sonneveld, M Haas, C Koeleman, N de Haan, SS Zeerleder, PC Ligthart, M Wuhrer, CE Schoot, G Vidarsson
Scientific Reports 7 (1), 8187, 2017

Plasma N-Glycan Signatures Associate With Features of Inflammatory Bowel Diseases
F Clerc*, M Novokmet*, V Dotz*, KR Reiding, N de Haan, GSM Kammeijer, H Dalebout, MR Bladergroen, F Vukovic, E Rapp, SR Targan, G Barron, N Manetti, A Latiano, DPB McGovern, V Annese, G Lauc, M Wuhrer
*contributed equally
Gastroenterology 155, 829-843, 2018  

Book chapters

High-Throughput Analysis of IgG Fc Glycopeptides by LC-MS
D Falck, BC Jansen, N de Haan, M Wuhrer
High-Throughput Glycomics and Glycoproteomics, 31-47, 2017
Methods in Molecular Biology book series

Sialic Acid Derivatization for the Rapid Subclass-and Sialic Acid Linkage-Specific MALDI-TOF-MS Analysis of IgG Fc-Glycopeptides
N de Haan, KR Reiding, M Wuhrer
High-Throughput Glycomics and Glycoproteomics, 49-62, 2017
Methods in Molecular Biology book series 


Contactgegevens

Leids Universitair Medisch Centrum
Gebouw 1
Kamer P-01-065

Albinusdreef 2
2333 ZA Leiden
Tel: +31 71 5266992

Postzone P1-Q
Postbus 9600
2300 RC Leiden

E-mail: N.de_Haan@lumc.nl