Dr George MC Janssen

Vakgebied(en)

  • Proteomics and Biochemistry

Key Publications

1: Kollenstart L, van der Horst SC, Vreeken K, Janssen GMC, Martino F, Vlaming

H, van Veelen PA, van Leeuwen F, van Attikum H. (2021) Epigenetics Identifier screens

reveal regulators of chromatin acylation and limited specificity of acylation

antibodies. Sci Rep. 11(1):12795

 

2: Kooij R, Liu S, Sapmaz A, Xin BT, Janssen GMC, van Veelen PA, Ovaa H, Dijke

PT, Geurink PP. (2020) Small-Molecule Activity-Based Probe for Monitoring Ubiquitin

C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J

Am Chem Soc. 142(39):16825-16841

 

3: Kollenstart L, de Groot AJL, Janssen GMC, Cheng X, Vreeken K, Martino F, Côté

J, van Veelen PA, van Attikum H. (2019) Gcn5 and Esa1 function as histone

crotonyltransferases to regulate crotonylation-dependent transcription. J Biol

Chem. 294(52):20122-20134

 

4: Jongsma ML, Berlin I, Wijdeven RH, Janssen L, Janssen GM, Garstka MA, Janssen

H, Mensink M, van Veelen PA, Spaapen RM, Neefjes J. (2016) An ER-Associated Pathway

Defines Endosomal Architecture for Controlled Cargo Transport. Cell.

166(1):152-66

 

5: Janssen G, Christis C, Kooy-Winkelaar Y, Edens L, Smith D, van Veelen P,

Koning F. (2015) Ineffective degradation of immunogenic gluten epitopes by currently

available digestive enzyme supplements. PLoS One e0128065

 

6: Hassan C, Kester MG, Oudgenoeg G, de Ru AH, Janssen GM, Drijfhout JW, Spaapen

RM, Jiménez CR, Heemskerk MH, Falkenburg JH, van Veelen PA. (2014) Accurate

quantitation of MHC-bound peptides by application of isotopically labeled

peptide MHC complexes. J Proteomics. 109:240-4

 

7: van de Kooij B, Rooswinkel RW, Kok F, Herrebout M, de Vries E, Paauwe M,

Janssen GM, van Veelen PA, Borst J. (2013) Polyubiquitination and proteasomal turnover

controls the anti-apoptotic activity of Bcl-B. Oncogene. 32(48):5439-48

 

8: Raap AK, Jahangir Tafrechi RS, van de Rijke FM, Pyle A, Wählby C, Szuhai K,

Ravelli RB, de Coo RF, Rajasimha HK, Nilsson M, Chinnery PF, Samuels DC, Janssen

GM. (2012) Non-random mtDNA segregation patterns indicate a metastable heteroplasmic

segregation unit in m.3243A>G cybrid cells. PLoS One 7(12):e52080

 

9: Janssen GM, Schwertman P, Wanga TA, Tafrechi RS, van den Broek PJ, Raap AK. (2009)

Transient and constitutive repression of cytoplasmic translation signaling in

cells with mtDNA mutation. Cell Mol Life Sci. 66(4):721-30

 

10: Janssen GM, Hensbergen PJ, van Bussel FJ, Balog CI, Maassen JA, Deelder AM,

Raap AK. (2007) The A3243G tRNALeu(UUR) mutation induces mitochondrial dysfunction and

variable disease expression without dominant negative acting translational

defects in complex IV subunits at UUR codons. Hum Mol Genet. 16(20):2472-81

 

11: Janssen GM, Neu A, 't Hart LM, van de Sande CM, Antonie Maassen J. Novel

mitochondrial DNA length variants and genetic instability in a family with

diabetes and deafness. (2006) Exp Clin Endocrinol Diabetes. 114(4):168-74

12: Larsson C, Koch J, Nygren A, Janssen G, Raap AK, Landegren U, Nilsson M. (2004) In

situ genotyping individual DNA molecules by target-primed rolling-circle

amplification of padlock probes. Nat Methods. 1(3):227-32

 

13: Janssen GM, Maassen JA, van Den Ouweland JM. (1999) The diabetes-associated 3243

mutation in the mitochondrial tRNA(Leu(UUR)) gene causes severe mitochondrial

dysfunction without a strong decrease in protein synthesis rate. J Biol Chem.

274(42):29744-8

 

14: Das T, Mathur M, Gupta AK, Janssen GM, Banerjee AK. (1998) RNA polymerase of

vesicular stomatitis virus specifically associates with translation elongation

factor-1 alphabetagamma for its activity. Proc Natl Acad Sci U S A.

95(4):1449-54

 

15: Brandsma M, Janssen GM, Möller W. (1997)Termination of quiescence in crustacea. The

role of transfer RNA aminoacylation in the brine shrimp Artemia. J Biol Chem.

272(46):28912-7

 

16: Janssen GM, van Damme HT, Kriek J, Amons R, Möller W. (1994) The subunit structure

of elongation factor 1 from Artemia. Why two alpha-chains in this complex? J

Biol Chem. 269(50):31410-7

 

17: Möller W, Janssen GM. (1992) Statistical evidence for remnants of the primordial

code in the acceptor stem of prokaryotic transfer RNA. J Mol Evol.

34(6):471-7

 

18: Janssen GM, Morales J, Schipper A, Labbé JC, Mulner-Lorillon O, Bellé R,

Möller W. (1991) A major substrate of maturation promoting factor identified as

elongation factor 1 beta gamma delta in Xenopus laevis. J Biol Chem.

266(23):14885-8

 

19: Möller W, Janssen GM. (1990) Transfer RNAs for primordial amino acids contain

remnants of a primitive code at position 3 to 5. Biochimie.

72(5):361-8

 

20: Janssen GM, Maessen GD, Amons R, Möller W. (1988) Phosphorylation of elongation

factor 1 beta by an endogenous kinase affects its catalytic nucleotide exchange

activity. J Biol Chem. 263(23):11063-6

 

21: Janssen GM, Möller W. (1988) Kinetic studies on the role of elongation factors 1

beta and 1 gamma in protein synthesis. J Biol Chem. 263(4):1773-8

 

22: Janssen GM, Möller W. (1988) Elongation factor 1 beta gamma from Artemia.

Purification and properties of its subunits. Eur J Biochem.

171(1-2):119-29


Contactgegevens

Leids Universitair Medisch Centrum
Gebouw 1
Kamer P01-74

Albinusdreef 2
2333 ZA Leiden
Tel: +31 71 5296408

Postbus 9600
2300 RC Leiden

E-mail: G.M.C.Janssen@lumc.nl