Although largely unknown outside the scientific community, the ApoE*3-Leiden.CETP mouse is as familiar to many cardiovascular researchers as Mickey Mouse is to the general public. Developed by LUMC and TNO, this mouse model has been used worldwide for decades to investigate the mechanisms underlying atherosclerosis and to evaluate novel therapeutic strategies. Remarkably, the story behind this globally adopted mouse model did not start in the laboratory, but with a special patient.
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A driving force
LUMC strongly underpins the idea that ‘Science is the driving force behind innovative healthcare’. Outcomes of top level fundamental, translational and clinical research by LUMC researchers form a strong basis for innovative and qualitative healthcare on a national, European and international level.
A real game changer was the development of the Dutch national research agenda (NWA) in 2015. The agenda reveals the complexity of the issues challenging Dutch society today. These issues are clustered in so called routes. LUMC is involved in many of these routes and contributes this way to solving important societal challenges.