Leiden Malaria Research 

Our studies are aimed at developing interventions against human malaria. Both by manipulating and examining the human malaria-parasite Plasmodium falciparum in culture, and by exploiting rodent malaria parasites (Plasmodium bergheiP. yoelii) in mice, mosquitoes and in vitro.

Main research themes

- Development of a malaria vaccine based on genetically attenuated parasites 

- Identification and analysis of parasite proteins that are (putative) targets for subunit vaccines

- Identification and analysis of parasite proteins that are (putative) targets for drugs

- Analysis of parasite-host interactions involved in pathology and disease

We provide the following resources and expertise:

  • Protocols and databases related to rodent malaria parasites (on a password protected 'SharePoint' environment)
  • Plasmids for genetic modification of rodent and human malaria parasites
  • Transgenic and mutant parasite lines (rodent and human malaria parasites)
  • Support in generation of transgenic and mutant parasites
  • A database containing information on genetically modified rodent parasite lines: see www.pberghei.eu.


Algemene informatie over malaria (general information on malaria in Dutch).

Head of the group: Dr. Chris J. Janse