Our studies are aimed at developing interventions against human malaria. Both by manipulating and examining the human malaria-parasite Plasmodium falciparum in culture, and by exploiting rodent malaria parasites (Plasmodium berghei, P. yoelii) in mice, mosquitoes and in vitro.
Main research themes
- Development of a malaria vaccine based on genetically attenuated parasites (GAP vaccine)
- Identification and analysis of parasite proteins that are (putative) targets for subunit vaccines
- Identification and analysis of parasite proteins that are (putative) targets for drugs
- Analysis of parasite-host interactions involved in pathology and disease
We provide the following resources and expertise:
- Protocols and databases related to rodent malaria parasites
- Plasmids for genetic modification of rodent and human malaria parasites
- Transgenic and mutant parasite lines (rodent and human malaria parasites)
- Support in generation of transgenic and mutant parasites
- A database containing information on genetically modified rodent parasite lines: see www.pberghei.eu.
Head of the group: Dr. Chris J. Janse