Head of Islet Research Lab
Assoc. Prof. F. (Françoise) Carlotti, PhD
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Introduction
I’m an Associate Professor at the Department of Internal Medicine, head of the Islet Research lab, and Group leader at Cure One. I also serve in the management team of the LUMC Innovation Theme RegMedTO (‘Regenerative Medicine of Tissues and Organs’).
Scientific research
I obtained research grants from JDRF, the Dutch Diabetes Research Foundation, the DON foundation, the European Foundation for the Study of Diabetes, and Health~Holland. I’m a PI in the Dutch regenerative medicine consortia RegMedXB and NWO-XL PanCreaTE, and in the H2020 European consortium ISLET, and Associate Investigator in the Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW.
In the Islet lab, we do fundamental and pre-clinical research on type 1 and type 2 diabetes with a focus on primary human pancreatic cells and beta-cell replacement therapy, building on an active clinical islet transplantation program.
Our two main research topics are:
i) Investigating mechanisms underlying beta-cell adaptation to (patho)physiological conditions, islet cell plasticity and alterations in beta-cell identity associated with a loss of function.
ii) Regenerative medicine for diabetes: Making new insulin-producing cells from human pluripotent stem cells using GMP-compliant processes for translation to the clinic.
In the Islet lab, we do fundamental and pre-clinical research on type 1 and type 2 diabetes with a focus on primary human pancreatic cells and beta-cell replacement therapy, building on an active clinical islet transplantation program.
Our two main research topics are:
i) Investigating mechanisms underlying beta-cell adaptation to (patho)physiological conditions, islet cell plasticity and alterations in beta-cell identity associated with a loss of function.
ii) Regenerative medicine for diabetes: Making new insulin-producing cells from human pluripotent stem cells using GMP-compliant processes for translation to the clinic.
