Our experts
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CPM is home to seven specialized research groups and collaborates closely with academic and industry partners in biomedical and clinical research. We also provide training for bachelor, master, and PhD students, as well as visiting scientists.
The CPM is organized in the 7 research groups:
- Proteomics
- Glycomics
- Metabolomics
- Bioinformatics
- Mass Spectrometry Imaging
- Tissue Glycomics
- Proteoform Profiling
Proteomics group
The proteomics group performs state-of-the art mass spectrometric analyses of peptides/proteins, with an historical focus on immunology, i.e. HLA-peptidomics, cell biology and microbiology.
Group leader: Paul Hensbergen
Glycomics group
Glycosylation plays important roles in immunity, development, infectious diseases and cancer. In addition, they are key determinants of efficacy and safety of biopharmaceuticals. Analyzing and understanding the glycosylation changes associated with various pathological processes provides a way to the development of new therapeutic and diagnostic means. In the Glycomics group, advanced analytical techniques are applied to study glycosylation in health and disease.
…Glycosylation plays important roles in immunity, development, infectious diseases and cancer. In addition, they are key determinants of efficacy and safety of biopharmaceuticals. Analyzing and understanding the glycosylation changes associated with various pathological processes provides a way to the development of new therapeutic and diagnostic means. In the Glycomics group, advanced analytical techniques are applied to study glycosylation in health and disease.
Group leader: Manfred Wuhrer
Metabolomics group
Metabolomics is defined as the systemic analysis of the metabolome, which encompasses the totality of the metabolites in a biological system, i.e., the end-points and intermediate products of metabolism. The Metabolomics group develops and applies advanced molecular analysis technologies and workflows in (pre-) clinical research with a particular focus on patho-physiological mechanisms and drug development. The Metabolomics group is dedicated to translational research and collaborates with many partners from diverse scientific fields around the globe.
MS imaging group
Mass spectrometry imaging (MSI) is a technology that simultaneously provides the spatial distribution of hundreds of biomolecules directly from tissue. At the MS imaging group of the CPM we use matrix-assisted laser desorption/ionization mass spectrometry imaging (MSI) to reveal the molecular architecture of tissues. The MSI technology allows the label-free and spatially correlated analysis of small molecules, metabolites, lipids, (proteolytic) peptides, proteins and their post-translational modifications using the same essential technology. The targeting of the different molecular classes is done through tailoring the sample preparation method. In the CPM MS imaging group we apply MSI to study pathoetiology and progression of various diseases on the molecular level.
…Mass spectrometry imaging (MSI) is a technology that simultaneously provides the spatial distribution of hundreds of biomolecules directly from tissue. At the MS imaging group of the CPM we use matrix-assisted laser desorption/ionization mass spectrometry imaging (MSI) to reveal the molecular architecture of tissues. The MSI technology allows the label-free and spatially correlated analysis of small molecules, metabolites, lipids, (proteolytic) peptides, proteins and their post-translational modifications using the same essential technology. The targeting of the different molecular classes is done through tailoring the sample preparation method. In the CPM MS imaging group we apply MSI to study pathoetiology and progression of various diseases on the molecular level.
Group leaders: Martin Giera & Manfred Wuhrer
Bioinformatics group
The Bioinformatics group uses computational tools to bring together data from different domains in order to better understand human disease. The Bioinformatics (Palmblad) Group’s primary research focus is computational proteomics – ranging from experimental design to reproducible workflows for data analysis, visualization and interpretation.
Group leader: Magnus Palmblad
Tissue glycomics group
The Tissue Glycomics group is dedicated to study glycosylation in human tissues in health and disease. Glycans are a fascinating class of biomolecules, known for their chemical complexity and strong implications in, amongst others, immunology, regenerative medicine, virology, and oncology. This interdisciplinary nature drives us to combine glycobiology with cutting-edge mass spectrometry to identify and exploit specific roles of glycoproteins in human (patho)physiology.
Group leader: Noortje de Haan
Proteoform profiling group
Proteoforms are very diverse and define the true functional identity of a protein. At the Proteoform Profiling Group we investigate their full diversity, going beyond individual post-translational modifications, to understand their structural and functional complexity. Our group is committed to advancing and applying mass spectrometric–based methods to elucidate their structure and function with the final goal of understanding proteoforms in the clinical and biopharmaceutical setting.
Group leader: Elena Dominguez Vega