Physician-researcher or researcher in training Ophthalmology

About your role

CSC and PCV are eye diseases that can lead to permanent vision loss, and their underlying mechanisms remain largely unknown. In this PhD project, you will combine fundamental laboratory research with clinical and genetic studies to better understand these disease processes. Using advanced multi-omics techniques, you will investigate how genetic factors, corticosteroids and changes in the choroid contribute to the development and progression of these conditions. You will work closely with researchers in the Netherlands and Denmark.

Your main responsibilities are:

• Working with primary choroidal endothelial cells, including gene knockdown experiments and functional analyses.
• Performing multi-omics analyses on proteomics, RNA sequencing and metabolomics datasets.
• Applying advanced imaging techniques to investigate blood vessel integrity.
• Investigating the genetic background of PCV, its overlap with CSC and age-related macular degeneration, and analysing long-term outcomes in different patient subgroups.

In addition, you will participate in translational collaborative studies on CSC within an international research consortium.

About your workplace

The clinical research will take place within Leiden University Medical Center, Amsterdam UMC and Rotterdam Eye Hospital, under the supervision of dr. Irene Temmerman.

The laboratory research will be conducted within the Ocular Angiogenesis Group at Amsterdam UMC, led by prof. Ingeborg Klaassen. You will also be supervised by dr. Elon van Dijk (Leiden University Medical Center) and prof. Camiel J.F. Boon (Ophthalmology, Amsterdam UMC). The project is carried out in close collaboration with a research group in Denmark.

About you

You are able to work accurately, maintain an overview and conduct research independently. You quickly master new techniques and carefully analyse complex research data. You enjoy collaborating with researchers from different disciplines and have a strong interest in clinical, genetic and translational research.

In addition, you have:

• A completed Master's degree in Medicine, Biomedical Sciences or a related field.
• Experience with cell culture (preferably endothelial cells or stem cells) and basic molecular techniques such as Western blotting and qPCR, or the motivation to learn these techniques.
• An interest in omics data analysis; experience is an advantage but not required.
• Excellent command of the English language, both written and spoken.

Our offer

Driven by health; that is our mission. This applies not only to our patients, but also to our employees. We strive for a safe, inclusive and equitable working environment in which talent development and connected leadership are central. To support continuous learning and development, we offer internal training and educational opportunities. In addition, you are entitled to an end-of-year bonus (8.3%), holiday allowance, bicycle scheme, sports budget, home-working allowance and an excellent commuting reimbursement scheme. As an employee of LUMC, you will also participate in the ABP pension fund. This means that no less than 70% of your pension contribution is paid by LUMC, leaving you with a higher net salary. A valuable benefit indeed.

See all employment conditions of the LUMC.

What do we represent?

As an academic medical centre, LUMC strives for a workforce that reflects the diversity of society. We are committed to the highest standards in healthcare, education and (international) research, where diverse perspectives are essential. Sustainability is also a key priority: we are committed to a healthy future, not only for people but also for the planet. In line with these values, we aim to provide a creative and inspiring workplace where everyone feels welcome, safe and valued. What matters to us is who you are and what you contribute, regardless of your background. Together, we work towards a sustainable and inclusive future, both for the people around us and for the world we live in. Together, we are LUMC.

More information

• As a physician-researcher, your salary ranges from € 3,724 to € 5,867 gross per month (salary scale 10, CAO UMC), based on a full-time appointment.
• As a researcher in training, your salary ranges from € 3,217 to €4,077 gross per month (salary scale PRO, CAO UMC), based on a full-time appointment.
• The appointment is for a period of 36 months.
• A salary increase of 3.5% will take effect on 1 May 2027.
• Detailed information about the remainder of the recruitment procedure will follow in due course.
• Acquisition in response to this vacancy is not appreciated.