PhD position 'mass spectrometry-based glycomics in steatotic liver disease'
You have 5 more days to apply
&width=400&height=400)
About your role
The ZonMw-funded GLYCELL project aims to generate novel and detailed insights into glycoconjugates present in human hepatocytes that play a functional role in the progression of MASLD. Advanced glycomics methodologies will be applied to perform in-depth spatial analyses of the glycoproteome of human hepatocytes using unique longitudinal MASLD patient cohorts and advanced in vitro models. You will work closely with clinical and cell biology research teams and use your findings to unravel the molecular mechanisms through which glycosylation contributes to the development of steatohepatitis and liver fibrosis.
Your main responsibilities include:
- Developing and applying nanoLC-MS and MS imaging glycomics methodologies.
- Performing in-depth analyses of the glycoproteome of human hepatocytes.
- Collaborating with clinical and cell biology research teams within the GLYCELL consortium.
- Investigating how glycosylation contributes to the development of steatohepatitis and liver fibrosis.
About your workplace
The Center for Proteomics and Metabolomics (CPM) at LUMC is the technological expertise centre and innovation partner of the LUMC in the analysis of proteins, metabolites, lipids and glycan structures from biological materials such as cells and tissues.
Mass spectrometry is the core technology within CPM and is complemented by nuclear magnetic resonance (NMR) and advanced miniaturised separation techniques.
The selected candidate will join the Tissue Glycomics Group under the supervision of dr. Noortje de Haan. In addition, the project will be carried out in close collaboration with the research groups of co-supervisors dr. Onno Holleboom (Amsterdam UMC, Department of Vascular Medicine in collaboration with Hepatology) and dr. Bruno Guigas (LUMC, Systemic Immunometabolism Group of LUCID).
About you
Curiosity about biomolecular questions and enthusiasm for interdisciplinary research characterise the way you work. You are able to connect complex analytical results to biomedical research questions. A proactive, structured and accurate approach enables you to maintain oversight within research projects. You enjoy collaborating with researchers from different disciplines and communicate your findings clearly and effectively.
In addition, you have:
- A master's degree in analytical chemistry or a biomedical/life sciences discipline, or you expect to obtain your degree in the near future.
- Practical experience in biomolecular mass spectrometry and a strong interest in this field.
- Preferably experience with computer scripting and data analysis.
- Excellent command of the English language, both written and spoken.
Our offer
Driven by health; that is our mission. This applies not only to our patients but also to our employees. We strive to create a safe, inclusive and equitable working environment where talent development and connected leadership are central. To support continuous learning and development, we offer internal training programmes and educational opportunities. In addition, you are entitled to an end-of-year bonus (8.3%), holiday allowance, a bicycle scheme, sports allowance, home-working compensation and an excellent commuting reimbursement scheme. As an employee of LUMC, you will also be enrolled in the ABP pension fund. This means that as much as 70% of your pension contribution is paid by LUMC, leaving you with a higher net salary. A nice benefit indeed!
What do we represent?
As an academic medical centre, LUMC strives for a workforce that reflects the diversity of society. We are committed to excellence in healthcare, education and (international) research, where diverse perspectives are essential. Sustainability is also one of our key priorities: we are committed to a healthy future, not only for people but also for the planet. In line with these values, we aim to provide a creative and inspiring workplace where everyone feels welcome, safe and recognised. We value who you are and what you contribute, regardless of your background. Together, we are building a sustainable and inclusive future for the people around us and for the world we live in. Together, we are LUMC.
More information
- As a motivated PhD candidate, your salary will be between €3,108 to €3,939 gross per month (scale PRO, CAO UMC), based on a full-time appointment.
- This is a four-year PhD trajectory.
- A salary increase of 3.5% will take effect on 1 July, followed by an additional 3.5% increase on 1 May 2027.
- Acquisition in response to this vacancy is not appreciated.