PhD Candidate in Immunology

About your role

This PhD project focuses on the role of post-translational protein modifications (PTMs) in systemic low-grade inflammation and the development of cardiometabolic and autoimmune diseases. You will combine laboratory research with translational applications by developing novel bispecific antibodies that locally inhibit complement activation. Working closely with researchers at Maastricht University, you will also contribute to scientific publications, international conferences and educational activities.

Your main responsibilities include:

• Developing and performing assays to measure PTMs, anti-PTM antibodies and complement factors in human samples using ELISA, Luminex and/or mass spectrometry.
• Designing bispecific antibodies and conducting in vitro and in vivo experiments to investigate their therapeutic potential.
• Collaborating with the Maastricht University research team to integrate human research data with preclinical experimental findings.
• Publishing scientific papers, presenting research findings at international conferences and contributing to educational activities within the department.

About your workplace

The Complement and Antibodies research group, led by Prof. Leendert Trouw, is part of the Department of Immunology at Leiden University Medical Center (LUMC). State-of-the-art research facilities support this project. In addition, you will collaborate with an extensive network of national and international researchers who provide scientific expertise, reagents and valuable feedback.

The project is carried out in close collaboration with the research group of Dr. M. van Greevenbroek at Maastricht University. A second PhD candidate based in Maastricht is investigating complementary aspects of the same project through epidemiological analyses of human studies. Regular joint meetings and exchange visits between both research locations are an integral part of the PhD programme.

About you

You have a strong interest in translational research within an interdisciplinary research environment. Working accurately and carefully comes naturally to you, and you combine analytical and critical thinking with clear communication. You are well organised, collaborate effectively with colleagues from different disciplines and can successfully combine multiple research activities. In addition, you are eager to learn, flexible and proactive when taking on new challenges.

In addition, you have:

• A completed Master's degree in Biomedical Sciences, Medicine, Biology or a related field.
• Strong laboratory skills and affinity with laboratory techniques such as ELISA.
• Experience with immunological assays using human cells and sera.
• Willingness and suitability to participate in in vivo research.
• Excellent command of scientific English, both written and spoken.
• Experience with SPSS and/or R, or the willingness to learn these programmes.

Our offer

Driven by health; that is our mission. This applies not only to our patients, but also to our employees. We strive to create a safe, inclusive and equitable working environment where talent development and collaborative leadership are central. To support your continuous learning and development, we offer internal training and educational opportunities. In addition, you will receive an end-of-year bonus (8.3%), holiday allowance, a bicycle scheme, a sports allowance, a home working allowance and an excellent commuting reimbursement scheme. As an LUMC employee, you will also be enrolled in the ABP pension fund. LUMC pays 70% of your pension contribution, leaving you with a higher net salary. A great benefit!

See all employment conditions of the LUMC.

What do we represent?

As an academic medical centre, LUMC strives for a workforce that reflects the diversity of society. We are committed to excellence in healthcare, education and (international) research, recognising that diverse perspectives are essential. Sustainability is also a key priority: we are committed to a healthier future, not only for people but also for our planet. In line with these values, we aim to provide a creative and inspiring workplace where everyone feels welcome, safe and valued. At LUMC, it is about who you are and what you contribute, regardless of your background. Together, we work towards a sustainable and inclusive future for the people around us and the world we live in. Together, we are LUMC.

More information

• As a motivated PhD candidate in immunology, your salary ranges from €3,217 to €4,077 gross per month (PhD salary scale, Collective Labour Agreement for Dutch University Medical Centers), based on a full-time appointment.
• A salary increase of 3.5% will take effect on 1 May 2027.
• The selection procedure consists of an initial review of applications, followed by one or more interviews.
• You will be offered a full-time, four-year PhD position (36 hours per week).
• This vacancy is open to both internal and external candidates. In accordance with LUMC policy, internal candidates will be given preference in the event of equal suitability.
• Acquisition in response to this vacancy is not appreciated.