Postdoc Rheumatology/Immunology
You have 6 more days to apply
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About your role
This postdoc position focuses on autoreactive B cells in people with systemic lupus erythematosus (SLE). These cells play an important role in SLE, as shown by the success of therapies that specifically target B cells. You will be the first to characterise these cells in lymphoid tissues and organoids, using techniques such as spectral flow cytometry, RNA sequencing, B cell repertoire analysis and functional assays. Your research will explore where B cell activation takes place, which routes are involved and how these cells remain quiescent after therapy. The combination of translational research, innovative techniques and direct relevance to patient care creates a varied and scientifically challenging research environment.
Your main tasks are:
- Studying autoreactive B cells in SLE using advanced immunological techniques.
- Analysing activation mechanisms and signalling pathways based on transcriptomic and functional data.
- Developing experimental strategies to study B cell activation in organoids.
- Sharing research findings through scientific publications and national and international presentations.
About your workplace
Leiden University Medical Center is an academic medical center where patient care, research and education are closely connected. The Department of Rheumatology is a recognised EULAR Centre of Excellence, bringing together care and research for various autoimmune diseases.
At the Laboratory for Experimental Rheumatology, you will join a dynamic research group of around 35 postdocs, PhD candidates and analysts. The SLE research team consists of a rheumatologist, PhD candidates and a postdoc, supervised by dr. Jolien Suurmond, immunologist and assistant professor. The laboratory combines fundamental immunological research with patient-related research to unravel the mechanisms of autoimmune diseases and develop innovative treatment strategies.
This research is also part of a study into CD19 CAR T cell therapy for autoimmune diseases. The project involves close collaboration with several departments within LUMC and Amsterdam UMC.
About you
Collaboration comes naturally to you, especially within fundamental research in B cell immunology. You work with a critical mindset and know how to adapt your experimental approach based on results. Clear communication in English is important in this international research environment.
In addition, you have:
- A completed PhD in immunology.
- Demonstrable interest in autoimmunity.
- Experience with immunological techniques, such as cell culture and (spectral) flow cytometry.
- Affinity with advanced data analysis, such as single-cell RNA sequencing and B cell repertoire analysis.
Our offer
Driven by health: that is our mission. This applies not only to our patients, but also to our employees. We are committed to creating a safe, inclusive and equitable working environment, with talent development and connected leadership at its core. To support continuous learning and development, we offer internal training and professional development opportunities.
You are also entitled to an end-of-year bonus of 8.3%, holiday allowance, a bicycle scheme, sports budget, home office allowance and an excellent commuting allowance. As an LUMC employee, you are affiliated with the ABP pension fund. LUMC pays 70% of your pension premium, which means you keep more net salary. A welcome benefit.
See all employment conditions of LUMC.
What do we represent?
As an academic medical center, LUMC aims to have a workforce that reflects society. We are committed to the highest quality in healthcare, education and international research, where diverse perspectives are essential. Sustainability is also a key priority: we work towards a healthy future, not only for people, but also for the planet.
In line with these values, we aim to be a creative and inspiring workplace where everyone feels at home, safe and recognised. What matters to us is who you are and what you contribute, regardless of your background. Together, we work towards a sustainable and inclusive future, for the people around us and for the world we live in. Together, we are LUMC.
More information
- As a postdoc, your salary will be at least €3,598 and at most €5,669 gross per month, based on a full-time position and in accordance with scale 10 of the CAO UMC.
- The appointment is for two years, with the possibility of a two-year extension.
- Giving a presentation is part of the application procedure.
- References will be requested as part of the application process.
- Applications from recruitment agencies will not be considered.