PhD candidate lipid droplets, antiviral immunity and translational infection models

About your role

Mechanistic and translational studies of virus-host interactions are central to this PhD project. You will investigate how lipid droplet-associated pathways influence antiviral immunity and infection outcomes using a combination of human primary cell systems, advanced infection models, mouse models, and gene-editing approaches. By integrating molecular virology, immunology, and cell biology, you will uncover mechanisms through which host metabolic pathways regulate viral replication and immune responses. The project bridges fundamental discovery and translational research, providing opportunities to validate findings in physiologically relevant model systems and contribute to the development of future host-directed antiviral strategies. In addition, you will actively present your work at international conferences and publish your findings in leading peer-reviewed journals..
Your main responsibilities will include:
•    Investigating the functional role of lipid droplet-associated host factors during viral infection.
•    Performing gene-editing and targeted perturbation experiments.
•    Studying antiviral signalling pathways and inflammatory responses in human primary cell models and established virus mouse models..
•    Presenting research findings at international conferences and publishing in peer-reviewed journals.

About your workplace

This PhD project is embedded within the interdisciplinary research group of dr. Sebenzile K. Myeni at the Leiden Center for Infectious Diseases (LUCID). The project involves close collaboration with research groups at LUMC as well as national and international partners. Training will be provided in advanced virology (BSL-3), human primary cell infection systems, mouse models, CRISPR technologies and immunological assays.

About you

A strong interest in virology, antiviral immunity and translational research is essential for success in this position. You enjoy collaborating with researchers from different disciplines and can communicate scientific findings clearly and effectively. You work in a structured manner, maintain oversight of multiple research activities and actively contribute to shared research goals.

In addition, you have:

• A completed master's degree in Biomedical Sciences, Immunology, Infection Biology, Molecular Biology, Medical Biology, Biotechnology or a related discipline.
• Experience with mammalian cell culture.
• A strong interest in host-pathogen interactions and antiviral immunity.
• Excellent English communication skills, both written and spoken, along with strong organisational and communication skills.

Experience in virology, animal research, immunology and microscopy is considered an advantage.

Our offer

Driven by health; that is our mission. This applies not only to our patients but also to our employees. We strive to create a safe, inclusive and equitable working environment in which talent development and collaborative leadership are central. To support continuous learning and growth, we offer internal training courses and educational opportunities. In addition, you are entitled to an end-of-year bonus (8.3%), holiday allowance, bicycle scheme, sports allowance, home-working allowance and an excellent commuting reimbursement scheme. As an employee of LUMC, you will also be enrolled in the ABP pension fund. This means that as much as 70% of your pension contribution is paid by LUMC, allowing you to retain more of your net salary. A valuable benefit.

See all employment conditions of the LUMC.

What do we represent?

As an academic medical centre, LUMC strives for a workforce that reflects the diversity of society. We are committed to the highest standards in healthcare, education and (international) research, where diverse perspectives are of crucial importance. Sustainability is also one of our core values: we are committed to a healthy future, not only for people but also for the planet. In line with these values, we aim to provide a creative and inspiring workplace where everyone feels welcome, safe and valued. At LUMC, it is about who you are and what you contribute, regardless of your background. Together, we work towards a sustainable and inclusive future for the people around us and for the world we live in. Together, we are LUMC.

More information

• As a PhD candidate, your salary will range from € 3,217 to € 4,077 gross per month (salary scale PRO, CAO UMC), based on a full-time appointment.
• A salary increase of 3.5% will take effect on 1 May 2027.
• The selection procedure consists of several stages. Detailed information about the application process will be provided at a later stage.
• Acquisition in response to this vacancy is not appreciated.