The LGTC is the genomics & transcriptomics facility of the LUMC. The LGTC is there to make things possible and to develop new technologies, applications, protocols and services.
Anybody in- and outside (world-wide) the LUMC, especially researchers and diagnostic laboratories performing (high-throughput) DNA and RNA analysis.
The development and facilitation of advanced, high-throughput methods, technology and equipment, biological resources and bioinformatic tools for genomic research of academic and industrial parties, in- and outside the LUMC.
Position in (inter)national context
The LGTC has state-of-the-art technology to perform (high-throughput) genomics and transcriptomics analysis. In general, technology is available from two or more suppliers giving the possibility to make the best choice based on the combination of performance and cost. The LGTC focuses on innovation and technology development, to make things possible, not on production. Some platforms available are quite unique world-wide, incl. an Array-on-Demand system from FlexGen, nanoliter PCR from Fluidigm and a single molecule sequencing system from Pacific Biosciences.
Cohesion in LUMC
The LGTC is participating in many research projects in the LUMC. Besides providing access to the technology, the LGTC can be contacted for advise, technological options, best methodological approach, cost analysis and training. For a few years now, the LGTC has extended its services portfolio with bioinformatics support, general and custom-designed. The LGTC organizes and participates in many courses where the focus is on new technologies and ways to analyse the data, e.g. next-generation sequencing and data analysis. To spread its knowledge to the general public, the LGTC joined the LeveDNA! initiative.
Future plans / investments
Foreseen are investments in automation, digital PCR and DNA sequencing technology, moving towards label-free, single molecule sequencing and from whole-sample to single-cell analysis.