LUMC Research themes

Neuroscience

The research mission of the Neuroscience theme is to better understand the underlying pathogenesis and clinical course of a wide range of nervous system disorders. This includes the central and peripheral nervous system, including nerves and muscles. We aim to identify novel targets for developing innovative treatments and the methodology that enables the assessment of relevant parameters.

Vision and mission

The nervous system is the most complex and fascinating organ of the human body. The delicate interplay of many types of neurons and other cells in and outside the brain critically determines wellbeing and health of the individual. Our nervous system is involved in virtually all of our functions.

The brain relies heavily on sensory input from the outside world, for which a wide range of specialised organs and receptors are available. These include smelling, visual input, hearing, tasting, and feeling. Muscles have a pivotal role in translating the output of the brain into meaningful actions. All information received by the central nervous system eventually results in motor output, like speaking or moving, but also in autonomic and endocrine output, regulating sleep, breathing or intestinal functions.

Collaboration is the key

We are committed to performing cutting edge patient care, research, teaching and training to enable these activities by curiosity-driven and clinic-driven laboratory and clinical research. We value Master students, PhD students and Postdocs as potential drivers of innovation and experienced technicians and other support staff as guardians of our work's quality and continuity.

The principle investigators that lead the basic and clinical research together with diagnostic groups are committed to fostering a collaborative, open culture to ensure good conduct, exchange of ideas, training and career management. We aim to reach out to peers and the general public within and outside the organisation at the national and international level to maximise the development and impact of our programs.

“Overlap and collaboration between the research themes is a key factor for success.”

About us

Jan Verschuuren, Professor of Neuromuscular Diseases

Prof. Jan Verschuuren, MD, PhD, neurologist, head of the Department of Neurology and chair of the Neuroscience research theme. His main research focus is on neuromuscular diseases, especially on disorders of muscle and neuromuscular synapse.

Email: J.J.G.M.Verschuuren@lumc.nl

Arn van den Maagdenberg, Professor of Molecular and Functional Neurogenetics

Prof. Arn van den Maagdenberg, PhD, neurogeneticist and neuroscientist, member of the management team of the Neuroscience research theme. His main research focus is on primary headache disorders, such as migraine and cluster headache, as well as comorbid disorders, including stroke and epilepsy.

Email: A.M.J.M.van_den_Maagdenberg@lumc.nl

Hermien Kan, Imaging Scientist

Hermien Kan, PhD, Imaging scientist, associate professor, member of the management team of the Neuroscience research theme. Her main research focus is on quantitative magnetic resonance imaging and spectroscopy of skeletal muscle.

Email: H.E.kan@lumc.nl

Research collaborations and alliances

Regional and national collaborations

International collaborations

Opportunities

For Businesses

The Neuroscience research theme is involved in various clinical and basic research collaborations. We would be pleased to discuss future collaborations. Please email us neuroscience@lumc.nl or call +31-(0)71-5262197.

For PhDs and Postdocs

The Neuroscience research theme has currently over 100 PhD students working on a wide variety of research topics. Vacancies are advertised through the LUMC site. For additional information please email us neuroscience@lumc.nl or call +31-(0)71-5262197.

For Students

Members of the Neuroscience research theme are involved in Bachelor, as well as Master study programs. The Faculty of Medicine offers the following Bachelor studies: Medicine, Biomedical Sciences or Clinical Technology, and the Master study programs, Medicine, Biomedical Sciences, Technical Medicine, with the specialisations Imaging & Intervention or Sensing & Stimulation. Members of the theme also teach at other faculties of Leiden University (for instance, the Faculty of Science and Social and Behavioural Sciences) and TU Delft. Several students combine their study with part-time work for one of our research clusters. If you are looking for a position, please email us neuroscience@lumc.nl or call +31-(0)71-5262197.

Sub-themes

Within the Neuroscience research theme, we defined several clusters that each cover a specific Neuroscience subtheme. These clusters form the starting point of the Neuroscience theme network in the Leiden University Medical Center (LUMC), and can change, fuse or emerge depending on the research focus. Together all clusters form the complete Neuroscience theme network.

The theme Neuroscience at the LUMC has a long-standing reputation in the international field. It combines activities of research groups in at least 14 departments, among which Anatomy and Embryology, Anaesthesiology, Pain Management and Clinical Physiology, Biomedical Data Sciences, Cell and Chemical Biology, Clinical Genetics, Ear, Nose and Throat, Human Genetics, Neurology, Neurosurgery, Orthopaedic Surgery, Ophthalmology, Psychiatry, Radiology, Rehabilitation, and Statistics.

The LUMC is the medical faculty of Leiden University and collaborates with other faculties of Leiden University for instance, with the Leiden Institute for Brain and Cognition (LIBC). The LUMC focuses on patient care, research and teaching.

The Neuroscience research theme combines diagnostics and experimental and clinical research in brain, nerve and muscle disorders. The research program ranges from fundamental neuroscience, neuroimaging and genetics to clinical translation. It aims to improve diagnostics and treatment in brain and muscle disorders. The theme Neuroscience houses many clinical research groups and fundamental research groups with several hundred clinical and basic researchers, laboratory technicians, PhD students, Postdocs, and staff.

Our sub-themes

Within the Neuroscience research theme, we defined several clusters that each cover a specific Neuroscience subtheme. These clusters form the starting point of the Neuroscience theme network in the Leiden University Medical Center (LUMC), and can change, fuse or emerge depending on the research focus. Together all clusters form the complete Neuroscience theme network.

The theme Neuroscience at the LUMC has a long-standing reputation in the international field. It combines activities of research groups in at least 14 departments, among which Anatomy and Embryology, Anaesthesiology, Pain Management and Clinical Physiology, Biomedical Data Sciences, Cell and Chemical Biology, Clinical Genetics, Ear, Nose and Throat, Human Genetics, Neurology, Neurosurgery, Orthopaedic Surgery, Ophthalmology, Psychiatry, Radiology, Rehabilitation, and Statistics.

The LUMC is the medical faculty of Leiden University and collaborates with other faculties of Leiden University for instance, with the Leiden Institute for Brain and Cognition (LIBC). The LUMC focuses on patient care, research and teaching.

The Neuroscience research theme combines diagnostics and experimental and clinical research in brain, nerve and muscle disorders. The research program ranges from fundamental neuroscience, neuroimaging and genetics to clinical translation. It aims to improve diagnostics and treatment in brain and muscle disorders. The theme Neuroscience houses many clinical research groups and fundamental research groups with several hundred clinical and basic researchers, laboratory technicians, PhD students, Postdocs, and staff.


Muscle and synapse disorders
Brain and behaviour
Circadian rhythm disorders
Chronic pain
Paroxysmal cerebral disorders (PaCD)
Sensory system disorders
Movement disorders
Neuro-endocrinology
Neuro-oncology
Neurotrauma and neurodegeneration
Neurovascular disorders
Technology development