Bone and soft tissue tumor pathology

The aim of our research is to identify tumor-specific changes in bone and soft tissue tumours that can be used for improvement of diagnosis, for targeted therapy, and for prediction of response to this therapy, thereby facilitating precision medicine for patients with sarcomas.

Molecular profiling of bone and soft tissue tumors

Within the Leiden Center for Computational Oncology the bone and soft tissue tumor group generates molecular profiles of various sarcomas, especially those with complex genomes, using various -omics techniques. The aim is to identify specific molecular alterations that can be used to improve diagnosis or for targeted therapy. In collaboration with the Cancer Immunogenomics group (PI: Dr. Noel de Miranda) the immune microenvironment in bone and soft tissue cancers is being characterized. In collaboration with the imaging mass spectrometry group (PI: Bram Heijs) we also explore the proteome.

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Molecular profiling of bone and soft tissue tumors

Within the Leiden Center for Computational Oncology the bone and soft tissue tumor group generates molecular profiles of various sarcomas, especially those with complex genomes, using various -omics techniques. The aim is to identify specific molecular alterations that can be used to improve diagnosis or for targeted therapy. In collaboration with the Cancer Immunogenomics group (PI: Dr. Noel de Miranda) the immune microenvironment in bone and soft tissue cancers is being characterized. In collaboration with the imaging mass spectrometry group (PI: Bram Heijs) we also explore the proteome.

Sarcoma modeling towards patient specific treatment

The bone and soft tissue tumor group is developing in vitro models to study the functional effect of molecular alterations, and to evaluate drug response. Models are generated using genetic manipulation of the presumed cell of origin (e.g. mesenchymal stem cell) as well as using tumor tissue straight from sarcoma patients, in 2 (confluent) as well as 3 dimensions (spheroid culture).

  • Judith Bovee, PI
  • Anne-Marie Cleton-Jansen, molecular biologist /KMBP
  • Suk Wai Lam, pathologist
  • Sanne Venneker, postdoc
  • Sheena Ong, PhD student
  • Siddh van Oost, PhD student
  • Debora Meijer, PhD student
  • Rick Ursem, PhD student
  • Inge Briaire- de Bruijn, technician
  • Pauline Weijers-Koster, technician
  • Brendy van den Akker, technician
  • Alwine Kruisselbrink, technician
…
  • Judith Bovee, PI
  • Anne-Marie Cleton-Jansen, molecular biologist /KMBP
  • Suk Wai Lam, pathologist
  • Sanne Venneker, postdoc
  • Sheena Ong, PhD student
  • Siddh van Oost, PhD student
  • Debora Meijer, PhD student
  • Rick Ursem, PhD student
  • Inge Briaire- de Bruijn, technician
  • Pauline Weijers-Koster, technician
  • Brendy van den Akker, technician
  • Alwine Kruisselbrink, technician

Team group 2.jpg