Functional and molecular neurogenetics of paroxysmal neurological brain disorders

In addition, our research activities focus on understanding specific triggering pathways and the main co-morbidities of migraine, i.e. epilepsy, depression and stroke.

Prof.dr. Arn M.J.M. van den Maagdenberg, Dr. Else A. Tolner

A specific focus is research in epilepsy, also because it is an important comorbidity of migraine. Not only have we identified various genes for specific forms of epilepsy (e.g. myoclonic epilepsy and focal epilepsy), but also we have shown that various gene mutations in core FHM genes have epilepsy as a clinical symptom. The close, but at present hardly understood, association of migraine and epilepsy is shown and studied in our transgenic mouse models. The most striking example, is a transgenic migraine mouse model that presents with sudden unexpected death in epilepsy for which we have unravelled neurobiological mechanisms. 

Prof.dr. Arn M.J.M. van den Maagdenberg
Principal Investigator / Professor Molecular and Functional Neurogenetics

Else A. Tolner
Senior researcher (Neurology)

Jean-Philippe M.S. Frimat
Senior researcher

Anisa Dehghani Mohammadi
Researcher
Georgii Krivoshein
PhD student

M. Susana Marques Mota Madeira Jorge
PhD student

Michel H.Y. Hu
PhD student (Neurology)

Dhanesh G. Kasi
PhD student (Neurology)