Student research projects

Possibilities

There are frequent opportunities for students to undertake shorter or longer research projects within the LUMC at the Center of Infectious Diseases, Dept of Parasitology,  Leiden Parasite Immunology Group. We are keen on students with interest in immunology and disease pathogenesis. The general outlines of the projects are available on our website. You can contact Professor Maria Yazdanbakhsh, Dr. B. Guigas, Dr. Hermelijn Smits or Dr. Erliyani Sartono.

Students studying Medicine, Biomedical sciences, Natural sciences can work on projects that range from field studies to characterization in vitro and in vivo. Immunoepidemiological databases are also available for those interested in statistical analysis of large datasets.

women working in front of a flowcast

Former/current/upcoming students and guest investigators and their research projects

Mariska van Huizen, BW Leiden, Master internship
Period: November 2016 - June 2016
Title: Effects of helminth-derived molecules on hepatic inflammation and steatosis in obese mice

Rachel Halkerston, University of Edinburgh, Summer student internship
Period: July 2016 – August 2016
Title: Modulation of brown adipocyte metabolism by helminth-derived molecules  

Itziar Muñoz Pagazaurtundua, student of Biomedical sciences at University of Alcalá de Henares
Period: February 2016 - June 2016
Title: Helminth infections, adipokines and insulin resistance

Kevin de Vos, student of Zadkine West Intermediate Vocational Education
Period: November 2105 – January 2016
Title: Total IgE before and after albendazole treatment in adults population lived in Nangapanda village, Flores Island, Indonesia.

Eva Goeyenbier, medical student LUMC 
Period: December 2015-June 2016
Title: Relationship between helminth infections, fatty acids and insulin resistance 

Mylène de Boer, BW Leiden, Master internship
Period: Period: October 2015 - March 2016
Title: Direct regulation of brown adipocyte metabolism by helminth-derived alarmins

Daphne Troost, medical student LUMC
Period: July –August 2015
Title: Fatty acid analysis in human plasma by GC-MS

Muhammad Ramadhan, Salma Alkasina Qurotuain, Lukito Ongko and Vanya Tedhy, medical students University of Indonesia
Period: November 2014-January 2015 
Title: Antibody isotypes, parasitic infection and risk factors of metabolic disesase among adults lived in Nangapanda, Flores island, Indonesia

Lauren Tambyrajah, BW Leiden, Master internship
Period: Period: February 2015 - November 2015
Title: Modulation of brown adipocyte metabolism by helminth-derived molecules

Patrick van der Zande, BW Leiden, Master internship
Period: Period: February 2015 - June 2015
Title: Modulation of adipocyte differentiation by helminth-derived glycoproteins      

Jack Law, University of Edinburgh, Summer student internship 
Period: July 2014 – August 2014
Title: Characterization of hypothalamic inflammatory state in S. Mansoni-infected mice 

Nina van de Lest, LUMC Honours Track MD student 
Period: September 2014 – January 2015
Title: Modulation of brown adipocyte metabolism by helminth-derived molecules

Hester Koppejan, BW Leiden, Master internship
Period: Period: May 2014 - Nov 2014
Title: Role of skin immunology in the study of protective immunity in different regimes of malaria vaccine administration

Evie van der Spoel, BW Leiden , Master internship
Period: Period: March 2014 - July 2014
Title: Functional analysis of metabolic pathways in schistosome-induced regulatory B cells

Marije Kuipers, University of Utrecht, Bachelor internship
Period: March 2014 - June 2014
Title: Characterisation of schistosome-secreted extracellular vesicles

Marie Agahozo, VU University, Bachelor internship
Period: March 2014 - June 2014
Title: Immunomodulatory effects of parasite-derived molecules on microglial cells

Elias Asuming Brempong, Kwame Nkrumah University of Science and Technology/Noguchi Memorial Institute for Medical Research
Period: December 2013 – January 2015
Title: Molecular understanding of IgE cross-reactivity in Africa

Vera Asscher, Leiden University
PhD student on excellent student trajectory MD/PhD

Estefania Cuesta Borras, University of Barcelona, Spain, Erasmus internship
Period: February 2013 - July 2013
Title: Effects of parasite-derived molecules on insulin sensitivity in skeletal muscle cells

Leonard Pelgrom, Leiden University, Master internship
Period: September 2013 - May 2014
Title: Control of hMSC differentiation into adipocytes and osteoblasts by parasite-derived molecules

William van der Puije, Noguchi Memorial Institute for Medical Research, Accra
Period: June 2013 – January 2014
Title: The targeted development of a new generation vaccins for schistosomiasis

Ruben van Helden, LUMC, Bachelor internship
Period: March 2013 - June 2013
Title: Th2 on antibody responses, parasitic infections and allergy among urban and rural Ghanaian school children

Esther de Jongste, VUMC, Master Infectious Diseases
Period: Feb 2013 - July 2013
Title: Establish the optimal route of administration of a vaccine consisting of live-attenuated malaria parasites in mice
 
Montse Janssen Bonas, Free University Amsterdam, Master internship
Period: January 2013 - July 2013
Title: Responsiveness of different human Breg subsets to PRRs and their capacity to produce IL-10

Wouter de Graaf,
BW-Leiden University, Joint Master internship with IHB department, under supervision of Prof P. van den Elsen
Period: January 2013 - October 2013
Title: Epigenetic control of innate immune responses in S. haematobium infected individuals

FrankVrieling, University of Leiden, Master internship
Period: November 2012 - July 2013
Title: Interactions between Schistosoma mansoni parasite-derived molecules and human mesenchymal stem cells

Valeria Squintani, University of Milan, Italy, Erasmus internship
Period: November 2012 - April 2013
Title: Effects of parasite-derived molecules on cytokine secretion and insulin sensitivity in adipocytes

Willem Venhuizen, Farmacy, University of Utrecht, Master internship
Period: September 2012 - February 2013
Title: Induction of tolerogenic DCs

Tyrill Martha, Infection and Immunity, VUMC, Master internship
Period: August 2012 - January 2013
Title: Responsiveness of different human Breg subsets to PRRs for their capacity to produce IL-10

Ulysse Ateba Ngoa, Albert Schweitzer Medical Hospital in Gabon, guest researcher
Period: April 2012 - June 2012
Title: How immune responses to malaria are affected by schistosome infections

Larissa de Clauser, BW, Leiden, shared wit Dept of Pulmonology, First Master internship
Period: March 2012 - August 2012
Titel: The protective farm effect and allergies: effect of farm dust on the barrier function of airway epithelial cells

Honorine Lima, Albert Schweitzer Medical Hospital in Gabon, guest researcher
Period: March 2012 - May 2012
Title: How immune responses to malaria are affected by schistosome infections

Huldah Sang, University of Wageningen, Molecular Life Sciences, Master internship
Period: March 2012 - August 2012
Title: Monocytes and their response to parasite antigens: An alternative for DCs?

Jacqueline Janse, Amsterdam
Period: February 2012 – December 2012
Titel: Food borne and orofecal infections in association with allergic sensitization - EuroPrevall study

Wouter de Graaf
, BW Leiden, first Master Internship
Period: February 2012 - August 2012
Titel: Food borne and orofecal infections in association with allergic sensitization - EuroPrevall study

Eva Zettlmeissl, University of Tuebingen, Medical Student, internship
Period: February - April 2012
Title: Development of regulatory T cells in Gabonese newborns: role of helminth-malaria co-infections

Churnalisa Doran, Rogier Achterberg and Mareen Datema, VU, BW students
Period: January 2011 - September 2011
Stage in het kader van het SchistoInir project: "Innate Immune response of Schistosome infected subjects"

Sanne de Jong,
Leiden University, BW student
Period: Jan 2011 - Sept. 2011
Title: The maturation of the immune system under conditions of high pathogen load

Firdaus Hamid, guest investigator – Indonesia
Period: January 2011- September 2012
Title: The identification of the risk and protective factors for atopy and allergic disease

Aprilianto Eddy Wiria, guest investigator – Indonesia
Period: January 2011- June 2012
Title: The impact of helminth infections on malarial parasites and disease outcome

Yenny Djuardi, guest investigator – Indonesia
Period: January 2011-April2011 & September 2011- June 2012
Title: Maturation of immune responses in children born to helminth infected mothers: impact on early childhood

Abena Amoah, Noguchi Memorial Institute for Medical research, Accra
Period: Jan 2011 - Dec. 2011
She will be working on an EU-project entitled 'Innate immune responses and immunoregulation in schistosomiasis: novel mechanisms in the control of infection and disease'.

Jaap Schreurs, Leiden University, BW student
Period: November 2010 - April 2010
Title: Immunological correlates of epidemiological transition: the regulatory network in helminth infection and type 2 diabetes mellitus.

Moustapha Mbow, guest investigator - Senegal
Period: May 2010 - August 2010,  Dec 2010 - Feb 2011
Title: The balance between Th17 and Treg during schistosome mediated pathology

Stefan Andersen, University of Copenhagen, B.Sc.
Period: January 2010 - April 2010
Title: Immune modulation: training in immunological methods

Eline Mlejnek, Leiden University, GNK/BW student
Period: May 2010 – October 2010
Title: The frequency and functional capacity of IL-10 producing B-cells in allergic asthmatic patients

Leonie Hussaarts, Leiden University, BW master II student
Period: April 2010 – October 2010
Title: A role for IL-33 in regulatory B cell induction in experimental parasitic worm infections

Christa Toenhake, Leiden University, BW bachelor student
Period: March 2010 - July 2010
Title: Phenotype and function of regulatory T cells in human malaria infection before and after treatment

Fong Lin, VU, Medical Biology master student
Period: March 2010 – September 2010
Title: Microbial modification of dendritic cell function: role in protection against experimental allergic asthma.

meeting student

Ulysse Ateba Ngoa, guest investigator - Gabon
Period: December 2009 – May 2010
Title: Understanding the immunological effects of vitamin A supplementation

Erlinda Marthias, guest investigator – Indonesia
Period: November 2009- January 2010
Title: Maturation of immune responses in children born to helminth infected mothers: impact on early childhood

Aprilianto Eddy Wiria, guest investigator – Indonesia
Period: October 2009 – April 2010
Place: LUMC
Title: The impact of helminth infections on malarial parasites and disease outcome

Mary Ng’endo Kanoi, Kenia, Biochemistry, bachelor student
Period: October 2009 – January 2010
Title: Balance of pro- and anti-inflammatory cytokines in healthy European donors to malaria antigens

Firdaus Hamid, guest investigator – Indonesia
Period: September 2009 – November 2009
Title: Identification of the risk and protective factors for atopy and allergic disease

Sonia Boender, VU, Public Health, bachelor student
Period: September 2009 – December 2009
Title: Immunomodulation of responses to latent tuberculosis antigens by helminth infection

Willemijn den Oudendammer, VU, Public Health, bachelor student
Period: September 2009 – December 2009
Title: Immune responses to active tuberculosis antigens, modulated by helminth infection and living environment
 
Tessa Dijksman, Leiden University, GNK student
Period: September 2009 – March 2010
Title: The frequency and functional capacity of IL-10 producing B-cells in allergic asthmatic patients
 
Barbara van der Hoeven, Leiden University
Period: March 2009 – September 2009
Title: Assessment of the role of RNase activity and glycosylation of
omega-1 on its Th2 polarizing properties through site-directed mutagenesis.

Pablo Martinez de Salazar, Albert Schweizer Hospital
Period: February 2009 – April 2009
Interleukine-17 expressing T cells (Th17) and Regulatory T cell (Tregs) subsets in Gabonese Loa-loa infected individuals

Kristiina Pulli, University of Helsinki, Studente Master of Sciences, Genetics
Period: September 2008 – April 2009
Title: Characterization of signalling pathways involved in Th2 polarization in human dendritic cells induced by S. mansoni egg derived protein omega-1

Rianne Vriend, Radboud University Nijmegen, master (thesis)
Period: April 2008 – June 2008
Title: Houdt de hygiene hypothese stand na 18 jaar onderzoek?

Brechje de Gier, VU, Medical Biology master student
Period: March 2008 – July 2008
Title: Regulatory T cells in Helminths and Malaria co-infections

Krystelle Nganou Makamdop, University Groningen, Studente Biomedische Wetenschappen
Period: February 2008 – August 2008
Identification of receptors on dendritic cells involved in the recognition of and immune polarization by Schistosoma mansoni eggs derived Excretory/secretory products

Maarten Eldering, VU, BW, master (thesis)
Period: January 2008 – August 2008
Title: Do helminth co-infections really influence the efficacy of major vaccines?
 
Luciën van der Vlugt, Leiden University, BW master II student
Period: December 2007 – August 2008
Title: The role of IL-10 producing regulatory B cells in protection for allergic disease during experimental chronic schistosomiasis

Sander Brooks, BW, bachelor
Period: October 2007 – February 2008
Title: Functional exploration of a TLR3 SNP

Yvonne Schmiedel, University of Tübingen
Period: September 2007 – December  2007
Title: Regulatory T cells in schistosomiasis

Laura de Bes, HLO/Polytechnic Leiden
Period: September 2007 – June 2008
Title: Gene expression of Toll-like receptors in a mouse model of Schistosoma mansoni

Brechje de Gier, VU, master (thesis)
Period: August 2007 - October 2007
Title: Immunology of parasites in preganancy

Widad Rifi, VU, master (thesis)
Period: July 2007 - March 2008
Title: Development of immune response during schistosimiasis

Angela van Lochem, Leiden University, BW master I student
Period: March 2007 - July 2007
Title: Cord blood subset cells expressing TLR2: Gabon versus Austria
 
Astrid Voskamp - Leiden University, Biomedische Wetenschappen
Period: May 2006 – January 2007
Title: Molecular differences in urban and rural children in Ghana

Jonathan Kadouch, VU Medical Biology master student
Period: February 2005 – July 2005
Title: Schistosoma mansoni induced immunomodulation: A role for allergy suppression in a mouse model?
 
Anna de Breij, Leiden University
Period: okt  ’04  - maart ’05
Title: Molecular changes in the regulatory network of immune cells as a function of changing pathogen exposure