Student research projects

Possibilities

There are frequent opportunities for students to join the Glycobiology of Parasitic Infections group for shorter or longer traineeships and research projects.
In particular masters/bachelors students in biomedical sciences, medicine, biology or chemistry with an interest in the molecular aspects of host-parasite interaction are invited to contact us. A general description of our research themes is available on our website.
Research projects for students usually fit with the latest research interests of PhD students and post-docs, and details will become clear when your project will be planned.
For more information about the possibilities contact Dr. Cornelis Hokke or Dr. Angela van Diepen

Some recent examples of projects of students and guest researchers in our group:

Sophie van Leur – Delft University, Bachelor student Life Science Technologies
Apr 2016 - Jul 2016 (Bachelor research project)
Project: IgE cross-reactivity of helminth parasite and allergen glycans

Astrid Dunweg – Leiden University, Bachelor student Biomedical sciences
Mar 2015 - Jul 2016 (Bachelor research project)
Project: Assessing the biological effect of anti-glycan antibodies on in vitro schistosomula killing

Thom Beeren – Leiden University, Bachelor student Biology
Mar 2016 – Jul 2016 (Bachelor research project)
Project: IgE responses to glycans in helminth-infected populations in Ghana

PinHsuan Lin - Leiden University, Master student Biomedical sciences
Jan 2015 - Nov 2015 (Master Research Project)
Project: Depletion and enrichment strategies for glycan biomarker detection in serum and urine of Onchocerca volvulus infected individuals

Erika Huijser - Leiden University, Bachelor student Biomedical sciences
March 2015 - July 2015
Project: Identification and characterization of immunomodulatory excreted/secreted helminth molecules
 

Atena Sugiyama  - 4th years student at Nagaoka University of Technology, Japan
Oct 2014 - Feb 2015
Project: molecular and immunological characterisation of potentially immunomodulatory recombinant glycoproteins produced in plants

Elizaveta Elshina - University of Edinburgh, Master student Infectious Diseases
July 2014 – Sept 2014
Project: glycan-mediated immune attack of schistosomula in an in vitro assay

David Edelschaap - Leiden University, Master student
Jan 2014 - Aug 2014
Project: Glycan-dependent immunomodulatory properties of helminth excreted and secreted molecules

Nahome Kribbe - VU Amsterdam, Master Student
August 2013 - December 2013
Project:  Application of an O-glycan microarray to study antibody responses to schistosome glycan antigens in vaccinated/infected baboons

Christiaan Kies -  LUMC, Master Student (GNK and BW)
August 2013 - December 2013
Project: Localization of and immune responses to antigenic glycans in S.mansoni larval stages

Lara van der Laan
- Leiden University, Master student
Feb 2013 – Aug 2013
Project: Molecular interactions between egg-derived glycoconjugates of the human parasite Schistosoma mansoni and C-type lectin receptors on
host cells. 

Diecke de Ronde - University of Utrecht, Master student
Oct 2012 - May 2013
Project: molecular interactions of the schistosome egg glycoprotein kappa-5 with C-type lectin receptors in the liver.

Laura Neumann - University of Natural Resources and Life Sciences in Vienna, guest researcher
Oct 2012 - May 2013
Project: glycan ligands of influenza hemaglutinins using affinity chromatography, glycan arrays and MS.

Rebecca Grootveld - LUMC, Medical Sciences (MW) student
Sept 2011 – July 2012
Project: Longitudinal analysis of anti-glycan antibody responses in Schistosoma haematobium-infected subjects using a glycan microarray

Alessandra Ravida - Dublin City University, guest researcher
June 2012 – July 2012
Project: Glycosylation analysis of an immunogenic Fasciola hepatica tegument preparation
 
Marie-Claire Eenhoorn – Master student Biomedical Sciences at the VU
Feb 2012 – July 2012
Project: Application of a glycan-micro array to study anti-glycan antibody responses in human schistosomiasis

Leroy van den Hoogen - Master student Biomedical Sciences at the VU
Feb 2012 – July 2012
Project: Glycan-dependent host-pathogen interactions in granuloma formation around Schistosoma mansoni eggs

Vincent van Hensbergen – Leiden University, Biology student
Feb 2012 – July 2012
Project: S.mansoni larval glycans as targets of antibody responses 

Maartje Doesburg - Master student Biomedical Sciences at the VU.
March 2011 - Aug 2011
Project: Interaction of Schistosoma mansoni glycan structures with C-type lectins on host immune cells.

Gilian Flohr – Master student Biomedical Sciences at the VU.
Feb 2011 – Aug 2011
Project: S.mansoni larval glycans as targets of antibody responses.

Sammy Shadad - Leiden University, Biology student
Jan 2011 - July 2011
Project: Dissection of anti-glycan antibody responses in schistosomiasis using glycan arrays

Miranda de Graaf - Erasmus MC, guest researcher
Jan 2011 - July 2012
Project: Construction and application of a glycan array for the investigation of influenza virus adhesion to glycans from trachea endothelium

Loes van Egmond - LUMC, Biomedical Sciences (BW) student
Sept 2010 – Jan 2011
Project: Analysis of anti-glycan antibody responses in S. mansoni-infected subjects using a glycan microarray

James Hewitson - University of Edinburgh, Guest Researcher
Aug 2010 and March 2012
Project: Characterisation of immunogenic glycoproteins and lectins from H. polygyrus

Nicky van Haeren - Leiden University, Biology student
Feb 2010 – Aug 2010
Project: Glycans as targets for intervention of schistosomiasis

Rick Versteegh - LUMC, Biomedical Sciences (BW) student
Feb 2010 – Aug 2010
Project: Characterization of the glycan-dependent immunogenicity of the S. mansoni egg glycoprotein kappa-5

Lisette Cornelissen - LUMC, Biomedical Sciences (BW) student
March 2010 - June 2010
Project: Regulated patterns of IgG Fc and Fab glycosylation in murine schistosomiasis

Luke Watson - University of Galway, Guest student
May 2009 – Aug 2009
Project: Analysis of the effect of Schistosoma infection on antibody glycosylation in the mouse model

Niels Smit - LUMC, Biomedical Sciences (BW) student
Nov 2008 - Aug 2009
Project: Developmental glycosylation of schistosomes analysed in relation to host immunity

Ruud Meijers - VU Amsterdam, Biomedical Sciences student
Feb 2009 - July 2009
Project: Recognition of Schistosoma mansoni egg antigens by human blood macrophages

Jan Willem Plaisier - LUMC, Biomedical Sciences (BW) student
Nov 2008 – March 2009
Project: The role of C-type lectins in the uptake of the Schistosoma mansoni egg glycoprotein k5

Linda van Nierop –VU Amsterdam, Biomedical Sciences student
Feb 2008 – Aug 2008
Project: Immunoglobulin glycosylation patterns  in schistosomiasis

Ulrike Lambertz – LUMC, Biomedical Sciences (BW) student
Feb 2007 – Aug 2008
Project: Glycoprotein-induced immunopathology in schistosomiasis

Lonneke van Schaik - Hogeschool Leiden, HLO student
Sept 2007 – July 2008
Project: Schistosome glycoproteins as initiators of granuloma formation

Louis Ates – VU Amsterdam, Biomedical Sciences (BW) student
Feb 2007 – Aug 2007
Project: Induction of in vitro granuloma formation by Schistosoma egg glycans