Radiotherapy for Ocular melanomas

A Kwf project 13400 / 2021-1 - Proton therapy and enucleation for eye melanoma

Treatment outcomes and patient involvement in treatment decision-making and 3D-imaging treatment planning was granted in 2021. This is a major step towards implementing peoples choice into the treatment. Patient advocates are closely cooperating in the project.

All patients treated with protons for eye melanomas are measured for outcome and quality of life (Proqem)

Together with JW Beenakker and HPTC a Varian grant is used to develop clipless eye treatment.

MRI delineation accuracy and positioning accuracy is assessed as parts of the process towards this clipless treatment before the project has even started.

In-vivo Dosimetry for Eye, Brain and Head and Neck proton radiation.

This project is in close cooperation with TU Delft (Dennis Schaart) and aims at developing an in vivo dosimetric device for proton irradiation. This is valid for proton eye treatments and other treatments in the head and neck areas. The research is pre-clinical and will deliver a prototype demonstrating its ability in clinical practice.

Optical coherence tomography and widefield fundus photography for 3D radiation-dose response relationship in partial eye irradiation using in-patient comparison

This KWF project aims at an NTCP for the eye as organ at risk while treating tumors nearby like meningiomas, sinusoidal and pituitary cancers. With PROMS, state of the art optical imaging combined with 3D dose distribution on patients who have been irradiated in the past in The Netherlands we aim to develop a normal tissue complication model to guide future novel (proton) treatments of cancers close to the optic tract.

Brachytherapy for eye melanoma

Brachytherapy for eye melanoma is number-wise the most important treatment for eye melanoma with good clinical results and stepwise improvement of the treatment resulting in the omission of thermotherapy as an adjunct. Retrospective analysis are at the base for this but with the protons and photons NTCP developments Brachytherapy is measured as well.