Research
The department of Human Genetics is a broadly oriented research department with focus on the (epi)genomic contribution to inherited and acquired diseases. The department is led by prof.dr. Silvère van der Maarel.
Research Programmes
Research performed in the department is clustered in four LUMC research programmes:
Human Genetics 1 - Functional Genomics of Muscle, Nerve and Brain Disorders
Human Genetics 2 - Genome Instability and Cancer
| Chromatin and DNA repair | DNA replication and responses to DNA damage | |
| DNA damage responses and cancer | Genome stability | Tumor Genetics |
| Regulation and Dynamics of Nucleotide Excision Repair (NER) |
Human Genetics 3 - Molecular Technology and Informatics for Personalised Medicine and Health
| Bioinformatics | Developmental Epigenomics | Population Genetics |
| BioSemantics | Genetic basis of genome instability |
Human Genetics 4 - Functional Genomics of Systemic Disorders
| Chronic inflammation | Developmental Genetics | Genetics and Systems Biology of the Metabolic Syndrome |
| Kidney Development, Disease and Regenerative Medicine |
Technology Platforms and Facilities
| Genomics (LGTC) | Bioinformatics | Forensic Laboratory for DNA Research (FLDO) |
| Genetically Modified Mouse Technology Platform |
The department actively participates in the LUMC Medical Research Profiles :
- Biomedical Research Profiles:Translational Neurosciences, Cancer Pathogenesis and Therapy, Vascular and Regenerative medicine
- Generic Research Profiles: Ageing, Innovation in Health Strategy and Quality of Care, Biomedical Imaging
The department has longstanding and intense collaborations worldwide. Principle investigators of Human Genetics are involved as coordinator of or participant in several national and international initiatives.