Fibbe, Prof.dr. W.E. (Wim)



Datum promotie
1 juni 1988
Proefschrift titel
Interleukin-1, a regulator of hematopoiesis
Datum oratie
25 oktober 2002
Titel oratie
Are we able to self-renew?


The bone marrow serves as reservoir for different classes of stem cells and contains hematopoietic stem cells, endothelial precursor cells, mesenchymal stem cells and multipotent adult progenitor cells. Hematopoietic stem cells have been used for clinical transplantation for many years and can now be mobilized from the marrow to the peripheral blood, a process termed hematopoietic stem cell mobilization. Mechanisms underlying this process of mobilization will be the subject of intense research for the coming years. In addition, the use of stem cells to induce transplantation tolerance may form a potential novel approach to apply allogeneic stem cell transplantation for solid organ transplants. Finally, the ability of stem cells that are present in the marrow to contribute to the repair of non-hematopoietic tissues will be a topic of research, but will also be translated into novel therapeutic strategies for hematopoietic and non-hematopoietic conditions.


Leids Universitair Medisch Centrum
Gebouw 1

Albinusdreef 2
2333 ZA Leiden
Tel: +31 71 526 3800

Postbus 9600
2300 RC Leiden