Research in Obstetrics: clinical studies
Since about two decades, clinical management of pathology in pregnancy is critically evaluated to provide appropriate evidence for our protocols and guidelines. Continuous improvement of obstetric care, aiming at the best possible outcome for both mother and child is our goal. Both rigourous evaluation, preferably using randomised controlled trials, as well as developing and testing new diagnostic tests and treatments are essential elements of our clinical research.
Many of our studies are done in close collaboration with other specialists in our center, such as neonatologists, pediatric cardiologists and geneticists. Moreover, to be able to study relatively rare diseases in a short period of time, we often participate in multicenter studies, both national and international.
Research in Obstetrics; Basic Science
In addition to our clinical research program, we have a strong interest in the etiology of fetal and maternal pathology. With the ultimate aim to improve our care, we strive to obtain more insight in the underlying mechanisms, e.g. on cellular, molecular or genetic level. In the LUMC, several internationally renowned laboratories work with us to answer questions such as why the fetus who is genetically quite different from its mother, is not rejected by the maternal immunesystem, unlike for instance transplanted organs. Further understanding of underlying mechanisms causing fetal or maternal diseases is required to be able to improve diagnostic strategies and treatment.
Examples of collaboration with other experts in the LUMC and in laboratories elswehere are studies into Parvovirus B19 infection in pregnancy, with the Virology lab, and immunologic research into backgrounds of fetal alloimmune thrombocytopenia with Sanquin laboratories. Other basic science research is directed at the development of therapies for fetal diseases e.g. using stemcell transplantation.
We are developing a biobank of materials obtained at chorion villus sampling, amniocentesis and at birth using the placenta, umbilical cord and amniotic fluid, as well as maternal blood samples and even fetal blood samples.
Pregnancy and immunology
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