Quality of life and Paracetamol In advanced Dementia (Q-PID) study

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Brief description

A Dutch study assessing the effect of paracetamol on quality of life, functioning, care dependency, neuropsychiatric symptoms and pain in persons with advanced dementia living in long-term care facilities.


Prof. dr. W.P. Achterberg, professor of Elderly Care Medicine
Prof. dr. B.S. Husebo, professor of Elderly Care Medicine (No)
Dr. M.A.A. Caljouw, assistant professor
Drs. P.H. van Dam, elderly care physician, PhD candidate

Participating organisations

WZH, Laurens, Argos zorggroep, Marente, Pieter van Foreest, Topaz, Saffier, Aafje and Florence                 


Drs. Paulien van Dam, elderly care physician, PhD candidate

Start study


Expected completion



There are no proven effective interventions regarding quality of life (QoL) for persons with dementia in long-term care facilities (LTCF). However, several interventions are effective in diminishing mediators of QoL (i.e., challenging behaviour, depressed mood, sleeping disorders), including pain treatment. Un(der)diagnosed and un(der)treated pain is a serious and common problem in persons with dementia. And although pain is difficult to assess in this group, the impact on QoL is probably considerable. There is evidence that pain has a negative impact on behaviour, mood, functioning and social participation, and benefit may be derived from the use of paracetamol.

Aims of the Q-PID study: to evaluate the effect of scheduled pain treatment with paracetamol on QoL, neuropsychiatric symptoms, ADL function, pain, care dependency, and (change in) use of psychotropic and pain medication in persons with advanced dementia living in long-term care facilities.                    

In collaboration with

SEFAS (Centre for Elderly Care and Nursing Home Medicine, Bergen Norway)


ZonMw (HGOG)
Ministry of Public Health, Wellbeing and Sports


van Dam, P.H., Achterberg, W.P., Husebo, B.S., Caljouw, M.A.A. Does paracetamol improve quality of life, discomfort, pain and neuropsychiatric symptoms in persons with advanced dementia living in long-term care facilities? A randomised double-blind placebo-controlled crossover (Q-PID) trial. BMC Med 18, 407 (2020). https://doi.org/10.1186/s12916-020-01858-6

van Dam, P.H., Caljouw, M.A.A., Slettebø, D.D., Achterberg, W.P., Husebo, B.S. Quality of Life and Pain Medication Use in Persons With Advanced Dementia Living in Long-Term Care Facilities. J Am Med Dir Assoc. 2019 Apr 11

van Dam, P.H., Achterberg, W.P., Gussekloo, J., Husebo, B.S., Caljouw, M.A.A. Quality of life and paracetamol in advanced dementia (Q-PID): protocol of a randomised double-blind placebo-controlled crossover trial

Posterpresentatie projectleidersbijeenkomst HGOG, Utrecht, 11 oktober 2016: Dam PH van, Caljouw MAA, Achterberg WP. Het effect van paracetamol op kwaliteit van leven van mensen met matige tot (zeer) ernstige dementie. Q-PID studie.

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