Dr. Erliyani Sartono

Senior researcher



Senior Researcher


Erliyani graduated with a degree in Biology from University of Indonesia, after which she worked as a researcher in the Department of Parasitology, Faculty of Medicine, University of Indonesia (group of Felix Partono). In 1990, she obtained a NUFFIC fellowship for training in cellular immunology of parasitic infections in Leiden University. She then continued her PhD focusing on T cell responses in human lymphatic filariasis. After finishing her PhD, she obtained a post doctoral position at LUMC and is now conducting research and is coordinating field studies in the laboratory of Prof. Maria Yazdanbakhsh and supervising a number of Indonesian PhD students.

Research interest

Erliyani Sartono studies the relationship between nematode parasites and their human host. She is part of the team that examines the effect that nematodes have on coinfections and on allergies and more recently on diabetes. This is done through conducting immuno-epidemiological studies in areas where parasitic infections are highly endemic, such as on Flores Island in Indonesia, or in Bekasi area of Java. Not only school children but also newborn responses are examined to understand the effect parasitic infections have on the development of immune responses.  She has currently coordinated a large trial to assess the effect of anthelmintic treatment on malarial parasitemia, allergy and immune response. New studies planned for the forthcoming five years will address the relationship between helminth infections, energy balance and diabetes.

Key publications

Wammes LJ, Hamid F, Wiria AE, Wibowo H, Sartono E, Maizels RM, Smits HH, Supali T, Yazdanbakhsh M. Regulatory T cells in human lymphatic filariasis: stronger functional activity in microfilaremics. PLoS Negl Trop Dis. 2012 May;6(5):e1655.

Djuardi Y, Wammes LJ, Supali T, Sartono E, Yazdanbakhsh M. Immunological footprint: the development of a child's immune system in environments rich in microorganisms and parasites. Parasitology. 2011 Oct;138(12):1508-18.

Hamid F, Wiria AE, Wammes LJ, Kaisar MM, Lell B, Ariawan I, Uh HW, Wibowo H, Djuardi Y, Wahyuni S, Schot R, Verweij JJ, van Ree R, May L, Sartono E, Yazdanbakhsh M, Supali T. A longitudinal study of allergy and intestinal helminth infections in semi urban and rural areas of Flores, Indonesia (ImmunoSPIN Study). BMC Infect Dis. 2011 Apr 1;11:83.

Djuardi Y, Sartono E, Wibowo H, Supali T, Yazdanbakhsh M. A longitudinal study of BCG vaccination in early childhood: the development of innate and adaptive immune responses. PLoS One. 2010 Nov 19;5(11):e14066.

Supali T, Verweij JJ, Wiria AE, Djuardi Y, Hamid F, Kaisar MM, Wammes LJ, van Lieshout L, Luty AJ, Sartono E, Yazdanbakhsh M. Polyparasitism and its impact on the immune system. Int J Parasitol. 2010 Aug 15;40(10):1171-6.

Supali T, Djuardi Y, Wibowo H, van Ree R, Yazdanbakhsh M, Sartono E. Relationship between different species of helminths and atopy: a study in a population living in helminth-endemic area in Sulawesi, Indonesia. Int Arch Allergy Immunol. 2010;153(4):388-94.

Sartono E, Lisse IM, Terveer EM, van de Sande PJ, Whittle H, Fisker AB, Roth A, Aaby P, Yazdanbakhsh M, Benn CS. Oral polio vaccine influences the immune response to BCG vaccination. A natural experiment. PLoS One. 2010 May 21;5(5):e10328

Wiria AE, Prasetyani MA, Hamid F, Wammes LJ, Lell B, Ariawan I, Uh HW, Wibowo H, Djuardi Y, Wahyuni S, Sutanto I, May L, Luty AJ, Verweij JJ, Sartono E, Yazdanbakhsh M, Supali T. Does treatment of intestinal helminth infections influence malaria? Background and methodology of a longitudinal study of clinical, parasitological and immunological parameters in Nangapanda, Flores, Indonesia (ImmunoSPIN Study). BMC Infect Dis. 2010 Mar 25;10:77.

Wammes LJ, Hamid F, Wiria AE, de Gier B, Sartono E, Maizels RM, Luty AJ, Fillié Y, Brice GT, Supali T, Smits HH, Yazdanbakhsh M. Regulatory T cells in human geohelminth infection suppress immune responses to BCG and Plasmodium falciparum. Eur J Immunol. 2010 Feb;40(2):437-42.

Djuardi Y, Wibowo H, Supali T, Ariawan I, Bredius RG, Yazdanbakhsh M, Rodrigues LC, Sartono E. Determinants of the relationship between cytokine production in pregnant women and their infants. PLoS One. 2009 Nov 9;4(11):e7711

Supali T, Djuardi Y, Pfarr KM, Wibowo H, Taylor MJ, Hoerauf A, Houwing-Duistermaat JJ, Yazdanbakhsh M, Sartono E. Doxycycline treatment of Brugia malayi-infected persons reduces microfilaremia and adverse reactions after diethylcarbamazine and albendazole treatment. Clin Infect Dis. 2008 May 1;46(9):1385-93.

Eriksson M, Sartono E, Martins CL, Balé C, Garly ML, Whittle H, Aaby P, Pedersen BK, Yazdanbakhsh M, Erikstrup C, Benn CS. A comparison of ex vivo cytokine production in venous and capillary blood. Clin Exp Immunol. 2007 Dec;150(3):469-76.

Wahyuni S, Sartono E, Supali T, van der Zee JS, Mangali A, van Ree R, Houwing-Duistermaat JJ, Yazdanbakhsh M. Clustering of allergic outcomes within families and households in areas endemic for helminth infections. Int Arch Allergy Immunol. 2005 Apr;136(4):356-64

Noordin R, Wahyuni S, Mangali A, Huat LB, Yazdanbakhsh M, Sartono E. Comparison of IgG4 assays using whole parasite extract and BmR1 recombinant antigen in determining antibody prevalence in brugian filariasis. Filaria J. 2004 Aug 12;3(1):8

Wahyuni S, Houwing-Duistermaat JJ, Syafruddin, Supali T, Yazdanbakhsh M, Sartono E. Clustering of filarial infection in an age-graded study: genetic, household and environmental influences. Parasitology. 2004 Mar;128(Pt 3):315-21.

Terhell AJ, Haarbrink M, van den Biggelaar A, Mangali A, Sartono E, Yazdanbakhsh M. Long-term follow-up of treatment with diethylcarbamazine on anti-filarial IgG4: dosage, compliance, and differential patterns in adults and children. Am J Trop Med Hyg. 2003 Jan;68(1):33-9.

Terhell AJ, Haarbrink M, Abadi K, Syafruddin, Maizels RM, Yazdanbakhsh M, Sartono E. Adults acquire filarial infection more rapidly than children: a study in Indonesian transmigrants. Parasitology. 2001 Jun;122(Pt 6):633-40

Sartono E, Lopriore C, Kruize YC, Kurniawan-Atmadja A, Maizels RM, Yazdanbakhsh M. Reversal in microfilarial density and T cell responses in human lymphatic filariasis.
Parasite Immunol. 1999 Nov;21(11):565-71.

Sartono E, Kruize YC, Kurniawan A, Maizels RM, Yazdanbakhsh M. Depression of antigen-specific interleukin-5 and interferon-gamma responses in human lymphatic filariasis as a function of clinical status and age. J Infect Dis. 1997 May;175(5):1276-80.

Sartono E, Kruize YC, Kurniawan A, Maizels RM, Yazdanbakhsh M. In Th2-biased lymphatic filarial patients, responses to purified protein derivative of Mycobacterium tuberculosis remain Th1.Eur J Immunol. 1996 Feb;26(2):501-4.

Sartono E, Kruize YC, Partono F, Kurniawan A, Maizels RM, Yazdanbakhsh M. Specific T cell unresponsiveness in human filariasis: diversity in underlying mechanisms. Parasite Immunol. 1995 Nov;17(11):587-94

Sartono E, Kruize YC, Kurniawan A, van der Meide PH, Partono F, Maizels RM, Yazdanbakhsh M. Elevated cellular immune responses and interferon-gamma release after long-term diethylcarbamazine treatment of patients with human lymphatic filariasis.
J Infect Dis. 1995 Jun;171(6):1683-7.



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E-mail: E.Sartono@lumc.nl