ARGON-OPTIMA

Het onderzoek

Artrose Research Groep Orthopedie Nederland - Outcome Predictors for TIMing of Arthroplasty

Projectleaders 

Collaboration 

  • Alrijne ziekenhuis, Leiderdorp
  • CHECK cohort
  • Erasmus Medisch Centrum, Rotterdam
  • Haga Ziekenhuis (Den Haag)
  • Medisch Centrum Haaglanden, Den Haag
  • Onze Lieve Vrouwe Gasthuis (Amsterdam)
  • Sint Antonius, Nieuwegein
  • Sint Maartenskliniek (Nijmegen)
  • Spaarne Ziekenhuis, Hoofddorp
  • UMCG (Groningen)
  • Viasana, Mill
  • Viecuri, Venlo

Project group for methodological support 

  • S.C. Cannegieter, PhD, Department of Clinical Epidemiology
  • S. le Cessie, Department of Clinical Epidemiology and Department of Medical Statistics and Bioinformatics
  • W.B. van den Hout, PhD, Department of Medical Decision Making

Research fellows 

Start/End Date 

2014 –  2017

Funding

Reumafonds   

Abstract

Although joint replacement surgery is one of the most effective interventions in osteoarthritis, the optimal timing of such surgery is crucial based on the irreversibility, invasiveness and the still limited long-term survival of the artificial joint. In addition, specific interventions might be able to satisfactory postpone the time to surgery or increase the post-operative effect of such surgery in certain cases. In 2013 a national research program,  ARGON (Artrose Research Groep Orthopedie Nederland), was started, instituted by the NOV (Netherlands Orthopaedic Association) and funded by the Reumafonds. Within this cooperative research program, the LUMC started with the ARGON-OPTIMAL study. This study aims to identify indicators for optimal timing of knee and hip replacement in patients with osteoarthritis. This will be done with the use of a comprehensive set of individual patient data from existing prospective cohorts and trials in the Netherlands and refined state of the art statistical techniques.

Aim

To identify indicators for optimal timing of knee and hip replacement in patients with osteoarthritis.