Wetenschappelijk onderzoek

Research theme Orthopaedics Traumasurgery Rehabilitation: Mobility in musculoskeletal sciences

In society, impairments and limitations of mobility have a major and increasing impact on the independency and quality of life of many persons and pose a large economic burden to society as well. As for more common conditions, in The Netherlands about 70,000 patients have a knee or hip arthroplasty, 55,000 persons suffer from hip, ankle or wrist fractures, and more than 25,000 from stroke annually, all with varying clinical outcome after intervention. The latter resulted in the overarching research theme of "Mobility", encompassing Musculoskeletal (MSK) pathology and Brain and nerve injuries. Unsatisfactory outcomes and complications are common in all designated subgroups of patients, leading to significant health care usage and loss of productivity. In order to address this issues, the research program focusses on two research themes: "Prognostic Clinical Modelling" and "Optimising Clinical Outcome". 

The research program is built on the extensive experience of clinical network building as well as methodological expertise in the development, evaluation and implementation of complex care and technology. 

The two common research themes with their subsequent subprograms are:

I. Prognostic Clinical Modelling 


Prospective population networks  collaboration Biomedical Sciences, Clinical Epidemiology & Hemostasis and Molecular Epidemiology:
  • Arthroplasty Patients
  • Prosthetic Joint Infection network
  • Burn injuries
Optimising efficacy of outcome: 
  • Bone and soft tissue tumors 
  • VTE events & thromboprofylaxis
  • Common Fracture Care
  • Brain Injury
Complex trauma care: 
  • Injury patterns
  • Pediatric fractures
  • Trauma systems & polytrauma care 
  • Bone Healing

II. Optimising Clinical Outcome


3-D printing implants in complex joint reconstructions. collaboration dpt. Experimental bacteriology, Infection diseases, Technical University Delft. Technological innovation 
  • Prosthetic Joint Infection (induction heating, nano-coatings)
  • Implant migration diagnostics (RSA)
  • Kinematic analysis and muscle activation
E-rehabilitation: Development, evaluation and implementation of e-technology in rehabilitation