Wetenschappelijk onderzoek

Research theme Orthopaedics, Trauma surgery, Rehabilitation: Mobility 

Physical impairments and limitations of mobility have a major impact on the independency and quality of life of many persons and pose a large economic burden to society. In the Netherlands annually about 75.000 patients have a knee or hip arthroplasty, 55.000 sustain a hip, ankle or wrist fracture, more than 25.000 suffering from a stroke and about 3000 patients diagnosed with bone and soft tissue tumors. All with varying clinical outcome after varying interventions surgical as well as conservative. Research is focused on the clinical expertise areas as defined by the 10 LUMC Research Themes. The overarching research theme of "Mobility", encompassing Musculoskeletal (MSK) pathology and Brain and nerve injuries results from the overarching denominator of musculoskeletal and neurosciences. Unsatisfactory outcomes and complications are common in all designated subgroups of patients, leading to significant health care usage and loss of productivity. In order to address these issues, the research program focusses on two research themes: "Prognostic Clinical Modelling" and "Optimising Clinical Outcome". 
The research program is built on the extensive experience of the involved clinical networks as well as methodological expertise in the development, evaluation and implementation of complex care and technology.  
The two common research themes with their subsequent subprograms are:

I. Prognostic Clinical Modelling 

Collaboration depts. Biomedical Sciences, Clinical Epidemiology, Molecular Epidemiology, Anesthesiology

Prospective population networks  
  • Arthroplasty Patients
    • Patients reported outcomes
    • Prosthetic Joint Infection network 
    • VTE events & thromboprophylaxis
    • Pain (opioid use)
  • Bone and soft tissue tumors 
    • Sarcoma
    • Fibrous dysplasia
  • Pediatric orthopaedics, hip dysplasia
  • Common Fracture Care
  • Complex trauma care
    • Injury patterns
    • Pediatric fractures
    • Trauma systems & polytrauma care 
    • Bone Healing 
    • Burn injuries
  • Stroke
  • Traumatic brain Injury

II. Optimising Clinical Outcome  

Collaboration dpt. Experimental bacteriology, Infection diseases, Technical University Delft, Rheumatology, Intensive Care, Physiotherapy
Technological innovation 
  • Prosthetic Joint Infection 
  • Implant migration diagnostics (RSA)
  • Kinematic analysis and muscle activation
  • Intraoperative tumor Imaging
3-D printing in complex joint reconstructions (e.g. bone tumors) E-rehabilitation: Development, evaluation and implementation of e-technology in rehabilitation Lifestyle interventions (physical activity)