Prof. dr. Jelle Goeman

Hoogleraar Biostatistiek


  • High-dimensional data
  • Multiple testing
  • Penalized regression
  • Statistical bioinformatics


"Once we really understand the question, the answer is often surprisingly simple." 

I aim to develop novel statistical methodology that is theoretically profound, but always motivated by practical data analysis problems. My research centers on high-dimensional data, such as arise in omics data, where we have many measurements per subject. This area lies on the interface between bioinformatics and statistics. My main interests are in global testing, penalized regression and multiple testing.

Selected recent publications

See google scholar for a full overview.


R.J.Meijer, T.J.P.Krebs, J.J.Goeman. 2015. A region-based multiple testing method for hypotheses ordered in space or time. SAGMB 14 (1) 1-20.

R.J.Meijer, J.J.Goeman. 2015. A multiple testing method for hypotheses structured in a Directed Acyclic Graph. Biometrical Journal 57 (1) 123-147.

J.J.Goeman, A.Solari. 2014. Tutorial in biostatistics: multiple hypothesis testing in genomics. Statistics in Medicine 33 (11) 1946-1978.

A.Solari, L.Finos, J.J.Goeman. 2014. Rotation-based multiple testing in the multivariate linear model. Biometrics 70 (4) 954-961.

R.J.Meijer and J.J.Goeman. 2013. Efficient approximate k-fold and leave-one-out cross-validation for ridge regression. Biometrical Journal 55 (2) 141–155.

A.Solari, S.le Cessie, and J.J.Goeman. 2012. Testing goodness-of-fit in regression: a general approach for specified alternatives. Statistics in Medicine 31 (28) 3656–3666.

J.J.Goeman, and L.Finos. 2012. The inheritance procedure: multiple testing of tree-structured hypotheses. SAGMB 11 (1), 1-18.

J.J.Goeman, and A.Solari. 2011. Multiple testing for exploratory research. Statistical Science 26 (4) 584–597.

J.J.Goeman, H.C.Van Houwelingen, and L.Finos. 2011. Testing against a high-dimensional alternative in generalized linear models: asymptotic type I error control. Biometrika 98 (2) 381-390.

J.J.Goeman, and A.Solari. 2010. The sequential rejection principle of familywise error control. Annals of Statistics 38 (6) 3782–3810.

J.J.Goeman. 2010. L1 penalized estimation in the Cox proportional hazards model. Biometrical Journal  52 (1) 70-84.  


Leids Universitair Medisch Centrum
Gebouw 2
Kamer S5-32

Einthovenweg 20
2333 ZC Leiden
Tel: +31 (0)715268569

Postzone S5-P
Postbus 9600
2300 RC Leiden