Key publications

Publications:

  • Szuhai K, de Jong D, Leung WY, Fletcher CD, Hogendoorn PC. Transactivating mutation of the MYOD1 gene is a frequent event in adult spindle cell rhabdomyosarcoma. J Pathol. 2014 Feb;232(3):300-7
  • Lenos K, Grawenda AM, Lodder K, Kuijjer ML, Teunisse AF, Repapi E, Grochola LF, Bartel F, Hogendoorn PC, Wuerl P, Taubert H, Cleton-Jansen AM, Bond GL, Jochemsen AG. Alternate splicing of the p53 inhibitor HDMX offers a superior prognostic biomarker than p53 mutation in human cancer. Cancer Res. 2012 Aug 15;72(16):4074-84.
  • Roukens MG, Alloul-Ramdhani M, Baan B, Kobayashi K, Peterson-Maduro J, van Dam H, Schulte-Merker S, Baker DA. Control of endothelial sprouting by a Tel-CtBP complex. Nat Cell Biol. 2010 Oct;12(10):933-42.
  • Roukens MG, Alloul-Ramdhani M, Vertegaal AC, Anvarian Z, Balog CI, Deelder AM, Hensbergen PJ, Baker DA.  Identification of a new site of sumoylation on Tel (ETV6) uncovers a PIAS-dependent mode of regulating Tel function. Mol Cell Biol. 2008 Apr;28(7):2342-57.
  • Vyas R, Kumar R, Clermont F, Helfricht A, Kalev P, Sotiropoulou P, Hendriks IA, Radaelli E, Hochepied T, Blanpain C, Sablina A, van Attikum H, Olsen JV, Jochemsen AG, Vertegaal AC, Marine JC. RNF4 is required for DNA double-strand break repair in vivo.
  • Cell Death Differ. 2013 Mar;20(3):490-502
  • Vertegaal AC. Uncovering ubiquitin and ubiquitin-like signaling networks. Chem Rev. 2011 Dec 14;111(12):7923-40.
  • Zhang L, Huang H, Zhou F, Schimmel J, Gontan Pardo C, Zhang T, Barakat TS, Sheppard KA, Mickanin C, Porter JA, Vertegaal ACO, van Dam H, Gribnau J, Chris X. Lu, ten Dijke P. (2012) RNF12 controls embryonic stem cell fate and morphogenesis in zebrafish embryos by targeting Smad7 for degradation. Mol Cell, 46:650-61.
  • Zhang L, Zhou F, Drabsch Y, Snaar-Jagalska E, Mickanin C, Huang H, Sheppard K-A, Lu C, and ten Dijke P. (2012) USP4 is regulated by Akt phosphorylation and deubiquitinates TGF-β type I receptor. Nat Cell Biology, 14:717-26.
  • Anderberg C, Cunha SI, Zhai Z, Cortez E, Pardali E, Johnson J, Franco M, Páez-Ribes M, Cordiner R, Fuxe J, Johansson BR, Goumans MJ, Casanovas O, ten Dijke P*, Arthur HM*, Pietras K* (2013) Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination. J. Exp. Med, 210(3):563-79. *Co-corresponding author.
  • Zhang, L., Zhou, F., de Vinuesa, A.G., de Kruijf, E.M., Mesker, W.E., Hui, L., Drabsch, Y., Li, Y., Bauer, A., Rousseau, A., Sheppard, K.-A., Mickanin, C., Kuppen, P.J.K., Lu, C.X. and ten Dijke, P. (2013). TRAF4 promotes TGF-b receptor signaling and drives breast cancer metastasis. Mol. Cell, 51(5):559-72.