All publications

Publications:

  1. Passtoors WM, Beekman M, Deelen J, van der Breggen R, Maier AB, Guigas B, Derhovanessian E, van Heemst D, de Craen AJ, Gunn DA, Pawelec G, Slagboom PE. Gene expression analysis of mTOR pathway: association with human longevity.. Aging cell 2013-Mar-03;12(1):24-31. (pubmed)
  2. Shi ST, de Gorter DJJ, Hoogaars WMH, 't Hoen PAC, ten Dijke P. Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy. Cellular and molecular life sciences 2013-Feb-28;70(3):407-423. (pubmed)
  3. Haverslag RT, de Groot D, Grundmann S, Meder B, Goumans MJ, Pasterkamp G, Hoefer IE, de Kleijn DPV. CD26 Inhibition Enhances Perfusion Recovery in ApoE-/-Mice. Current vascular pharmacology 2013-Jan-31;11(1):21-28. (pubmed)
  4. Post S, van den Broek AJ, Rensing BJ, Pasterkamp G, Goumans MJ, Doevendans PA. Reduced CD26 expression is associated with improved cardiac function after acute myocardial infarction Insights from the REPERATOR study. Journal of molecular and cellular cardiology 2012-Dec-31;53(6):899-905. (pubmed)
  5. Pardali E, ten Dijke P. TGF beta Signaling and Cardiovascular Diseases. International journal of biological sciences 2012-Dec-31;8(2):195-213. (pubmed)
  6. Mohseny AB, Cai YP, Kuijjer M, Xiao W, van den Akker B, de Andrea CE, Jacobs R, ten Dijke P, Hogendoorn PCW, Cleton-Jansen AM. The activities of Smad and Gli mediated signalling pathways in high-grade conventional osteosarcoma. European journal of cancer 2012-Dec-31;48(18):3429-3438. (pubmed)
  7. Moerkamp AT, Goumans MJ. Cardiac Regeneration: Stem Cells and Beyond. Current medicinal chemistry 2012-Dec-31;19(35):5993-6002. (pubmed)
  8. Maring JA, Trojanowska M, ten Dijke P. ROLE OF ENDOGLIN IN FIBROSIS AND SCLERODERMA. International review of cell and molecular biology, vol 297 2012-Dec-31;297:295-308. (pubmed)
  9. Drabsch Y, ten Dijke P. TGF-beta signalling and its role in cancer progression and metastasis. Cancer and metastasis reviews 2012-Dec-31;31(3-4):553-568. (pubmed)
  10. Smits AM, van Oorschot AA, Goumans MJ. Isolation and differentiation of human cardiomyocyte progenitor cells into cardiomyocytes.. Methods in molecular biology (clifton, n.j.) 2012-Dec-28;879:339-49. (pubmed)
  11. Raap AK, Tafrechi RSJ, van de Rijke FM, Pyle A, Wahlby C, Szuhai K, Ravelli RBG, de Coo RFM, Rajasimha HK, Nilsson M, Chinnery PF, Samuels DC, Janssen GMC. Non-Random mtDNA Segregation Patterns Indicate a Metastable Heteroplasmic Segregation Unit in m.3243A > G Cybrid Cells. Plos one 2012-Dec-18;7(12). (pubmed)
  12. Huang SD, Holzel M, Knijnenburg T, Schlicker A, Roepman P, McDermott U, Garnett M, Grernrum W, Sun C, Prahallad A, Groenendijk FH, Mittempergher L, Nijkamp W, Neefjes J, Salazar R, ten Dijke P, Uramoto H, Tanaka F, Beijersbergen RL, Wessels LFA, Bernards R. MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-beta Receptor Signaling. Cell 2012-Nov-21;151(5):937-950. (pubmed)
  13. Post S, Post MC, van den Branden BJ, Eefting FD, Goumans MJ, Stella PR, van Es HW, Wildbergh TX, Rensing BJ, Doevendans PA. Early statin treatment prior to primary PCI for acute myocardial infarction: REPERATOR, a randomized placebo-controlled pilot trial. Catheterization and cardiovascular interventions 2012-Nov-01;80(5):756-765. (pubmed)
  14. Zhang J, Zhang XF, Zhang L, Zhou FF, van Dinther M, ten Dijke P. LRP8 mediates Wnt/ss-catenin signaling and controls osteoblast differentiation. Journal of bone and mineral research 2012-Oct-31;27(10):2065-2074. (pubmed)
  15. Seghers L, de Vries MR, Pardali E, Hoefer IE, Hierck BP, ten Dijke P, Goumans MJ, Quax PHA. Shear induced collateral artery growth modulated by endoglin but not by ALK1. Journal of cellular and molecular medicine 2012-Oct-31;16(10):2440-2450. (pubmed)
  16. Gong K, Zhou FF, Huang HZ, Gong YD, Zhang L. Suppression of GSK3 beta by ERK mediates lipopolysaccharide induced cell migration in macrophage through beta-catenin signaling. Protein & cell 2012-Oct-31;3(10):762-768. (pubmed)
  17. de Gorter DJJ, Jankipersadsing V, ten Dijke P. Deregulated Bone Morphogenetic Protein Receptor Signaling Underlies Fibrodysplasia Ossificans Progressiva. Current pharmaceutical design 2012-Sep-30;18(27):4087-4092. (pubmed)
  18. Karkampouna S, ten Dijke P, Dooley S, Kruithof-de Julio M. TGF beta Signaling in Liver Regeneration. Current pharmaceutical design 2012-Sep-30;18(27):4103-4113. (pubmed)
  19. Zhou FF, Gong K, Song B, Ma T, van Laar T, Gong YD, Zhang L. The APP intracellular domain (AICD) inhibits Wnt signalling and promotes neurite outgrowth. Biochimica et biophysica acta-molecular cell research 2012-Aug-31;1823(8):1233-1241. (pubmed)
  20. Zhang L, Zhou FF, Li YH, Drabsch Y, Zhang J, van Dam H, ten Dijke P. Fas-associated Factor 1 Is a Scaffold Protein That Promotes beta-Transducin Repeat-containing Protein (beta-TrCP)-mediated beta-Catenin Ubiquitination and Degradation. Journal of biological chemistry 2012-Aug-31;287(36). (pubmed)
  21. Sundqvist A, Zieba A, Vasilaki E, Herrera Hidalgo C, Söderberg O, Koinuma D, Miyazono K, Heldin CH, Landegren U, Ten Dijke P, van Dam H. Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion.. Oncogene 2012-Aug-27;. (pubmed)
  22. den Haan MC, Grauss RW, Smits AM, Winter EM, van Tuyn J, Pijnappels DA, Steendijk P, Gittenberger-De Groot AC, van der Laarse A, Fibbe WE, de Vries AAF, Schalij MJ, Doevendans PA, Goumans MJ, Atsma DE. Cardiomyogenic differentiation-independent improvement of cardiac function by human cardiomyocyte progenitor cell injection in ischaemic mouse hearts. Journal of cellular and molecular medicine 2012-Jul-31;16(7):1508-1521. (pubmed)
  23. Zhang L, Zhou FF, Drabsch Y, Gao R, Snaar-Jagalska BE, Mickanin C, Huang HZ, Sheppard KA, Porter JA, Lu CX, ten Dijke P. USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-beta type I receptor. Nature cell biology 2012-Jul-31;14(7):717-726. (pubmed)
  24. Kruithof BPT, Duim SN, Moerkamp AT, Goumans MJ. TGF beta and BMP signaling in cardiac cushion formation: Lessons from mice and chicken. Differentiation 2012-Jul-31;84(1). (pubmed)
  25. Gittenberger-de Groot AC, Winter EM, Bartelings MM, Goumans MJ, DeReuiter MC, Poelmann RE. The arterial and cardiac epicardium in development, disease and repair. Differentiation 2012-Jul-31;84(1). (pubmed)
  26. Cai J, Pardali E, Sanchez-Duffhues G, ten Dijke P. BMP signaling in vascular diseases. Febs letters 2012-Jul-31;586(14):1993-2002. (pubmed)
  27. Zhang L, Huang HZ, Zhou FF, Schimmel J, Pardo CG, Zhang TT, Barakat TS, Sheppard KA, Mickanin C, Porter JA, Vertegaal ACO, van Dam H, Gribnau J, Lu CX, ten Dijke P. RNF12 Controls Embryonic Stem Cell Fate and Morphogenesis in Zebrafish Embryos by Targeting Smad7 for Degradation. Molecular cell 2012-Jun-08;46(5):650-661. (pubmed)
  28. De Boeck M, Ten Dijke P. Key role for ubiquitin protein modification in TGF beta signal transduction. Upsala journal of medical sciences 2012-May-31;117(2):153-165. (pubmed)
  29. van Meeteren LA, Thorikay M, Bergqvist S, Pardali E, Stampino CG, Hu-Lowe D, Goumans MJ, ten Dijke P. Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting. Journal of biological chemistry 2012-May-25;287(22). (pubmed)
  30. Zhou FF, Huang HZ, Zhang L. Bisindoylmaleimide I enhances osteogenic differentiation. Protein & cell 2012-Apr-30;3(4):311-320. (pubmed)
  31. Tan HL, Glen E, Topf A, Hall D, O'Sulliyan JJ, Sneddon L, Wren C, Avery P, Lewis RJ, ten Dijke P, Arthur HM, Goodship JA, Keayney BD. Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation. Human mutation 2012-Apr-30;33(4):720-727. (pubmed)
  32. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NYO, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ETW, Banhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Bechet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi XN, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahova M, Cai DS, Cai JY, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao LZ, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LAM, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RCC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SSL, Chen WL, Chen X, Chen XM, Chen XQ, Chen YG, Chen YY, Chen YQ, Chen YJ, Chen ZX, Cheng A, Cheng CHK, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AMK, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RSB, Clarke PGH, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coppens GHCI, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronje MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CAM, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LMD, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Diaz-Araya G, Diaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan QH, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan HZ, Fan J, Fan QW, Fan Z, Fang SY, Fang YQ, Fanto M, Fanzani A, Farkas T, Farre JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng QL, Feng YJ, Fesus L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao JM, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng JF, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, Ghosh P, Giammarioli AM, Giatromanolaki AN, Gibson SB, Gilkerson RW, Ginger ML, Ginsbe. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012-Apr-30;8(4):445-544. (pubmed)
  33. Kemaladewi DU, de Gorter DJ, Aartsma-Rus A, van Ommen GJ, Ten Dijke P, 't Hoen PA, Hoogaars WM. Cell-type specific regulation of myostatin signaling.. Faseb journal : official publication of the federation of american societies for experimental biology 2012-Apr-30;26(4):1462-72. (pubmed)
  34. Langers AMJ, Verspaget HW, Hawinkels LJAC, Kubben FJGM, van Duijn W, van der Reijden JJ, Hardwick JCH, Hommes DW, Sier CFM. MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients. British journal of cancer 2012-Apr-24;106(9):1495-1498. (pubmed)
  35. Vinuesa AG, Sancho R, García-Limones C, Behrens A, Ten Dijke P, Calzado MA, Muñoz E. Vanilloid receptor-1 regulates neurogenic inflammation in colon and protects mice from colon cancer.. Cancer research 2012-Apr-01;72(7):1705-16. (pubmed)
  36. Bultot L, Guigas B, Von Wilamowitz-Moellendorff A, Maisin L, Vertommen D, Hussain N, Beullens M, Guinovart JJ, Foretz M, Viollet B, Sakamoto K, Hue L, Rider MH. AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase. Biochemical journal 2012-Apr-01;443:193-203. (pubmed)
  37. van Dijk RA, Engels CC, Schaapherder AF, Mulder-Stapel A, ten Dijke P, Hamming JF, Lindeman JHN. Visualizing TGF-beta and BMP signaling in human atherosclerosis: a histological evaluation based on Smad activation. Histology and histopathology 2012-Mar-31;27(3):387-396. (pubmed)
  38. Viollet B, Guigas B, Garcia NS, Leclerc J, Foretz M, Andreelli F. Cellular and molecular mechanisms of metformin: an overview. Clinical science 2012-Mar-31;122(5-6):253-270. (pubmed)
  39. Pulkki MM, Mottershead DG, Pasternack AH, Muggalla P, Ludlow H, van Dinther M, Myllymaa S, Koli K, ten Dijke P, Laitinen M, Ritvos O. A Covalently Dimerized Recombinant Human Bone Morphogenetic Protein-15 Variant Identifies Bone Morphogenetic Protein Receptor Type 1B as a Key Cell Surface Receptor on Ovarian Granulosa Cells. Endocrinology 2012-Mar-31;153(3):1509-1518. (pubmed)
  40. Zhou FF, Zhang XF, van Dam H, ten Dijke P, Huang HZ, Zhang L. Ubiquitin-specific Protease 4 Mitigates Toll-like/Interleukin-1 Receptor Signaling and Regulates Innate Immune Activation. Journal of biological chemistry 2012-Mar-30;287(14). (pubmed)
  41. van Mil A, Grundmann S, Goumans MJ, Lei ZY, Oerlemans MI, Jaksani S, Doevendans PA, Sluijter JP. MicroRNA-214 inhibits angiogenesis by targeting Quaking and reducing angiogenic growth factor release. Cardiovascular research 2012-Mar-15;93(4):655-665. (pubmed)
  42. Zhang L, Shi ST, Zhang J, Zhou FF, ten Dijke P. Wnt/beta-catenin signaling changes C2C12 myoblast proliferation and differentiation by inducing Id3 expression. Biochemical and biophysical research communications 2012-Mar-02;419(1):83-88. (pubmed)
  43. Wong MC, van Diepen JA, Hu LH, Guigas B, de Boer HC, van Puijvelde GH, Kuiper J, van Zonneveld AJ, Shoelson SE, Voshol PJ, Romijn JA, Havekes LM, Tamsma JT, Rensen PCN, Hiemstra PS, Berbee JFP. Hepatocyte-specific IKK beta expression aggravates atherosclerosis development in APOE*3-Leiden mice. Atherosclerosis 2012-Feb-28;220(2):362-368. (pubmed)
  44. Wong MC, van Diepen JA, Hu L, Guigas B, de Boer HC, van Puijvelde GH, Kuiper J, van Zonneveld AJ, Shoelson SE, Voshol PJ, Romijn JA, Havekes LM, Tamsma JT, Rensen PC, Hiemstra PS, Berbée JF. Hepatocyte-specific IKKβ expression aggravates atherosclerosis development in APOE*3-Leiden mice.. Atherosclerosis 2012-Feb-28;220(2):362-8. (pubmed)
  45. Naber HPH, Wiercinska E, Pardali E, van Laar T, Nirmala E, Sundqvist A, van Dam H, van der Horst G, van der Pluijm G, Heckmann B, Danen EHJ, ten Dijke P. BMP-7 inhibits TGF-beta-induced invasion of breast cancer cells through inhibition of integrin beta(3) expression. Cellular oncology 2012-Feb-28;35(1):19-28. (pubmed)
  46. Antonov AS, Antonova GN, Fujii M, Ten Dijke P, Handa V, Catravas JD, Verin AD. Regulation of endothelial barrier function by TGF-beta type I receptor ALK5: Potential role of contractile mechanisms and heat shock protein 90. Journal of cellular physiology 2012-Feb-28;227(2):759-771. (pubmed)
  47. ten Dijke P, Egorova AD, Goumans MJTH, Poelmann RE, Hierck BP. TGF-beta Signaling in Endothelial-to-Mesenchymal Transition: The Role of Shear Stress and Primary Cilia. Science signaling 2012-Feb-21;5(212). (pubmed)
  48. Ten Dijke P, Egorova AD, Goumans MJ, Poelmann RE, Hierck BP. TGF-β signaling in endothelial-to-mesenchymal transition: the role of shear stress and primary cilia.. Science signaling 2012-Feb-21;5(212). (pubmed)
  49. van der Kraan PM, Goumans MJ, Davidson EB, ten Dijke P. Age-dependent alteration of TGF-beta signalling in osteoarthritis. Cell and tissue research 2012-Jan-31;347(1):257-265. (pubmed)
  50. van Meeteren LA, ten Dijke P. Regulation of endothelial cell plasticity by TGF-beta. Cell and tissue research 2012-Jan-31;347(1):177-186. (pubmed)
  51. Krieglstein K, Miyazono K, ten Dijke P, Unsicker K. TGF-beta in aging and disease. Cell and tissue research 2012-Jan-31;347(1):5-9. (pubmed)
  52. Dooley S, ten Dijke P. TGF-beta in progression of liver disease. Cell and tissue research 2012-Jan-31;347(1):245-256. (pubmed)
  53. van Oorschot AAM, Smits AM, Pardali E, Doevendans PA, Goumans MJ. Low oxygen tension positively influences cardiomyocyte progenitor cell function. Journal of cellular and molecular medicine 2011-Dec-31;15(12):2723-2734. (pubmed)
  54. van Meeteren LA, Goumans MJ, ten Dijke P. TGF-beta Receptor Signaling Pathways in Angiogenesis; Emerging Targets for Anti-Angiogenesis Therapy. Current pharmaceutical biotechnology 2011-Dec-31;12(12):2108-2120. (pubmed)
  55. Stephenne X, Foretz M, Taleux N, van der Zon GC, Sokal E, Hue L, Viollet B, Guigas B. Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status. Diabetologia 2011-Dec-31;54(12):3101-3110. (pubmed)
  56. Morris E, Chrobak I, Bujor A, Hant F, Mummery C, ten Dijke P, Trojanowska M. Endoglin Promotes TGF-beta/Smad1 Signaling in Scleroderma Fibroblasts. Journal of cellular physiology 2011-Dec-31;226(12):3340-3348. (pubmed)
  57. Coomans CP, Biermasz NR, Geerling JJ, Guigas B, Rensen PCN, Havekes LM, Romijn JA. Stimulatory Effect of Insulin on Glucose Uptake by Muscle Involves the Central Nervous System in Insulin-Sensitive Mice. Diabetes 2011-Dec-31;60(12):3132-3140. (pubmed)
  58. Bax NAM, Pijnappels DA, van Oorschot AAM, Winter EM, de Vries AAF, van Tuyn J, Braun J, Maas S, Schalij MJ, Atsma DE, Goumans MJ, Gittenberger-de Groot AC. Epithelial-to-mesenchymal transformation alters electrical conductivity of human epicardial cells. Journal of cellular and molecular medicine 2011-Dec-31;15(12):2675-2683. (pubmed)
  59. Krause C, Kloen P, Ten Dijke P. Elevated transforming growth factor β and mitogen-activated protein kinase pathways mediate fibrotic traits of Dupuytren's disease fibroblasts.. Fibrogenesis & tissue repair 2011-Dec-28;4(1). (pubmed)
  60. Linssen MML, van Raalte DH, Toonen EJM, Alkema W, van der Zon GC, Dokter WH, Diamant M, Guigas B, Ouwens DM. Prednisolone-induced beta cell dysfunction is associated with impaired endoplasmic reticulum homeostasis in INS-1E cells. Cellular signalling 2011-Nov-30;23(11):1708-1715. (pubmed)
  61. Zhou FF, Gong K, van Laar T, Gong YD, Zhang L. Wnt/beta-catenin signal pathway stabilizes APP intracellular domain (AICD) and promotes its transcriptional activity (vol 412, pg 68, 2011). Biochemical and biophysical research communications 2011-Nov-18;415(2):428-428. (pubmed)
  62. Kemaladewi DU, van Heiningen SH, Aartsma-Rus A, van Ommen GJB, ten Dijke P, 't Hoen PAC, Hoogaars WMH. Interference of myostatin and TGF-beta signaling by antisense-mediated exon skipping in ALK4/5 receptors. Neuromuscular disorders 2011-Oct-31;21(9-10):704-704. (pubmed)
  63. Han GW, Li FL, ten Dijke P, Wang XJ. Temporal Smad7 Transgene Induction in Mouse Epidermis Accelerates Skin Wound Healing. American journal of pathology 2011-Oct-31;179(4):1768-1779. (pubmed)
  64. De Naeyer H, Ouwens DM, Van Nieuwenhove Y, Pattyn P, 't Hart LM, Kaufman JM, Sell H, Eckel J, Cuvelier C, Taes YE, Ruige JB. Combined Gene and Protein Expression of Hormone-Sensitive Lipase and Adipose Triglyceride Lipase, Mitochondrial Content, and Adipocyte Size in Subcutaneous and Visceral Adipose Tissue of Morbidly Obese Men. Obesity facts 2011-Oct-31;4(5):407-416. (pubmed)
  65. Sluijter JP, Doevendans PA, Goumans MJ. Letter by Sluijter et al Regarding Article, "Human Cardiac Stem Cell Differentiation Is Regulated by a Mircrine Mechanism". Circulation 2011-Oct-25;124(17). (pubmed)
  66. Orlova VV, Liu Z, Goumans MJ, ten Dijke P. Controlling angiogenesis by two unique TGF-beta type I receptor signaling pathways. Histology and histopathology 2011-Sep-30;26(9):1219-1230. (pubmed)
  67. Lissenberg-Thunnissen SN, de Gorter DJJ, Sier CFM, Schipper IB. Use and efficacy of bone morphogenetic proteins in fracture healing. International orthopaedics 2011-Sep-30;35(9):1271-1280. (pubmed)
  68. Coomans CP, Geerling JJ, Guigas B, van den Hoek AM, Parlevliet ET, Ouwens DM, Pijl H, Voshol PJ, Rensen PCN, Havekes LM, Romijn JA. Circulating insulin stimulates fatty acid retention in white adipose tissue via K-ATP channel activation in the central nervous system only in insulin-sensitive mice. Journal of lipid research 2011-Sep-30;52(9):1712-1722. (pubmed)
  69. Bot PT, Grundmann S, Goumans MJ, de Kleijn D, Moll F, de Boer O, van der Wal AC, van Soest A, de Vries JP, van Royen N, Piek JJ, Pasterkamp G, Hoefer IE. Forkhead box protein P1 as a downstream target of transforming growth factor-beta induces collagen synthesis and correlates with a more stable plaque phenotype. Atherosclerosis 2011-Sep-30;218(1):33-43. (pubmed)
  70. Bax NAM, van Oorschot AAM, Maas S, Braun J, van Tuyn J, de Vries AAF, Gittenberger-de Groot AC, Goumans MJ. In vitro epithelial-to-mesenchymal transformation in human adult epicardial cells is regulated by TGF beta-signaling and WT1. Basic research in cardiology 2011-Sep-30;106(5):829-847. (pubmed)
  71. Zhou FF, Zhang L, van Laar T, van Dam H, ten Dijke P. GSK3 beta inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb. Molecular biology of the cell 2011-Sep-15;22(18):3533-3540. (pubmed)
  72. Ramkisoensing AA, Pijnappels DA, Askar SFA, Passier R, Swildens J, Goumans MJ, Schutte CI, de Vries AAF, Scherjon S, Mummery CL, Schalij MJ, Atsma DE. Human Embryonic and Fetal Mesenchymal Stem Cells Differentiate toward Three Different Cardiac Lineages in Contrast to Their Adult Counterparts. Plos one 2011-Sep-09;6(9). (pubmed)
  73. Lagendijk AK, Goumans MJ, Burkhard SB, Bakkers J. MicroRNA-23 Restricts Cardiac Valve Formation by Inhibiting Has2 and Extracellular Hyaluronic Acid Production. Circulation research 2011-Sep-02;109(6):649. (pubmed)
  74. Wiercinska E, Naber HPH, Pardali E, van der Pluijm G, van Dam H, ten Dijke P. The TGF-beta/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system. Breast cancer research and treatment 2011-Aug-31;128(3):657-666. (pubmed)
  75. Hawinkels LJAC, ten Dijke P. Exploring anti-TGF-beta beta therapies in cancer and fibrosis. Growth factors 2011-Aug-31;29(4):140-152. (pubmed)
  76. Zhou FF, Gong K, van Laar T, Gong YD, Zhang L. Wnt/beta-catenin signal pathway stabilizes APP intracellular domain (AICD) and promotes its transcriptional activity. Biochemical and biophysical research communications 2011-Aug-19;412(1):68-73. (pubmed)
  77. Rogers MB, Kruithof B, Nagarajan N, Fritz D, Xu JW, Frank D, Mortlock D. Turning off bone morphogenetic protein (BMP) 2. Developmental biology 2011-Aug-01;356(1):265-265. (pubmed)
  78. Olieslagers S, Pardali E, Tchaikovski V, ten Dijke P, Waltenberger J. TGF-beta 1/ALK5-induced monocyte migration involves PI3K and p38 pathways and is not negatively affected by diabetes mellitus. Cardiovascular research 2011-Aug-01;91(3):510-518. (pubmed)
  79. Mummery C, Goumans MJ. Shedding New Light on the Mechanism Underlying Stem Cell Therapy for the Heart. Molecular therapy 2011-Jul-31;19(7):1186-1188. (pubmed)
  80. Liu J, van Mil A, Vrijsen K, Zhao JJ, Gao L, Metz CHG, Goumans MJ, Doevendans PA, Sluijter JPG. MicroRNA-155 prevents necrotic cell death in human cardiomyocyte progenitor cells via targeting RIP1. Journal of cellular and molecular medicine 2011-Jul-31;15(7):1474-1482. (pubmed)
  81. Egorova AD, Van der Heiden K, Van de Pas S, Vennemann P, Poelma C, DeRuiter MC, Goumans MJTH, Gittenberger-de Groot AC, ten Dijke P, Poelmann RE, Hierck BP. Tgf beta/Alk5 Signaling Is Required for Shear Stress Induced Klf2 Expression in Embryonic Endothelial Cells. Developmental dynamics 2011-Jul-31;240(7):1670-1680. (pubmed)
  82. de Gorter DJJ, van Dinther M, Korchynskyi O, ten Dijke P. Biphasic Effects of Transforming Growth Factor beta on Bone Morphogenetic Protein-Induced Osteoblast Differentiation. Journal of bone and mineral research 2011-Jun-30;26(6):1178-1187. (pubmed)
  83. Drabsch Y, ten Dijke P. TGF-beta Signaling in Breast Cancer Cell Invasion and Bone Metastasis. Journal of mammary gland biology and neoplasia 2011-Jun-30;16(2):97-108. (pubmed)
  84. Langer HF, Orlova VV, Xie CP, Kaul S, Schneider D, Lonsdorf AS, Fahrleitner M, Choi EY, Dutoit V, Pellegrini M, Grossklaus S, Nawroth PP, Baretton G, Santoso S, Hwang ST, Arnold B, Chavakis T. A Novel Function of Junctional Adhesion Molecule-C in Mediating Melanoma Cell Metastasis. Cancer research 2011-Jun-15;71(12):4096-4105. (pubmed)
  85. van Diepen JA, Wong MC, Guigas B, Bos J, Stienstra R, Hodson L, Shoelson SE, Berbee JFP, Rensen PCN, Romijn JA, Havekes LM, Voshol PJ. Hepatocyte-specific IKK-beta activation enhances VLDL-triglyceride production in APOE(star)3-Leiden mice. Journal of lipid research 2011-May-31;52(5):942-950. (pubmed)
  86. Zhou F, van Laar T, Huang H, Zhang L. APP and APLP1 are degraded through autophagy in response to proteasome inhibition in neuronal cells.. Protein & cell 2011-May-31;2(5):377-83. (pubmed)
  87. Timmers L, Lim SK, Hoefer IE, Arslan F, Lai RC, van Oorschot AAM, Goumans MJ, Strijder C, Sze SK, Choo A, Piek JJ, Doevendans PA, Pasterkamp G, de Kleijn DPV. Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction. Stem cell research 2011-May-31;6(3):206-214. (pubmed)
  88. Simonis-Bik AMC, Boomsma DI, Dekker JM, Diamant M, de Geus EJC, 't Hart LM, Heine RJ, Kramer MHH, Maassen JA, Mari A, Tura A, Willemsen G, Eekhoff EMW. The heritability of beta cell function parameters in a mixed meal test design. Diabetologia 2011-May-31;54(5):1043-1051. (pubmed)
  89. Zhang L, Zhou FF, van Laar T, Zhang J, van Dam H, ten Dijke P. Fas-associated factor 1 antagonizes Wnt signaling by promoting beta-catenin degradation. Molecular biology of the cell 2011-May-01;22(9):1617-1624. (pubmed)
  90. Joziasse IC, Smith KA, Chocron S, van Dinther M, Guryev V, van de Smagt JJ, Cuppen E, ten Dijke P, Mulder BJM, Maslen CL, Reshey B, Doevendans PA, Bakkers J. ALK2 mutation in a patient with Down's syndrome and a congenital heart defect. European journal of human genetics 2011-Apr-30;19(4):389-393. (pubmed)
  91. Egorova AD, Khedoe PPSJ, Goumans MJTH, Yoder BK, Nauli SM, ten Dijke P, Poelmann RE, Hierck BP. Lack of Primary Cilia Primes Shear-Induced Endothelial-to-Mesenchymal Transition. Circulation research 2011-Apr-29;108(9):1093. (pubmed)
  92. Egorova AD, Khedoe PPSJ, Goumans MJTH, Yoder BK, Nauli SM, ten Dijke P, Poelmann RE, Hierck BP. Lack of Primary Cilia Primes Shear-Induced Endothelial-to-Mesenchymal Transition. Circulation research 2011-Apr-29;108(9):1093. (pubmed)
  93. Shi S, Hoogaars WMH, de Gorter DJJ, van Heiningen SH, Lin HY, Hong CC, Kernaladewi DU, Aartsma-Rus A, ten Dijke P, 't Hoen PAC. BMP antagonists enhance myogenic differentiation and ameliorate the dystrophic phenotype in a DMD mouse model. Neurobiology of disease 2011-Feb-28;41(2):353-360. (pubmed)
  94. Boekhorst BCT, Bovens SM, Hellings WE, van der Kraak PH, de Kolk KWV, Vink A, Moll FL, van Oosterhout MF, de Vries JP, Doevendans PA, Goumans MJ, de Kleijn DP, van Echteld CJ, Pasterkamp G, Sluijter JP. Molecular MRI of murine atherosclerotic plaque targeting NGAL: a protein associated with unstable human plaque characteristics. Cardiovascular research 2011-Feb-28;89(3):680-688. (pubmed)
  95. van der Heide LP, van Dinther M, Moustakas A, ten Dijke P. TGF beta Activates Mitogen- and Stress-activated Protein Kinase-1 (MSK1) to Attenuate Cell Death. Journal of biological chemistry 2011-Feb-18;286(7):5003-5011. (pubmed)
  96. Pellegrini M, Claps G, Orlova VV, Barrios F, Dolci S, Geremia R, Rossi P, Rossi G, Arnold B, Chavakis T, Feigenbaum L, Sharan SK, Nussenzweig A. Targeted JAM-C deletion in germ cells by Spo11-controlled Cre recombinase. Journal of cell science 2011-Jan-31;124(1):91-99. (pubmed)
  97. Pardali E, van der Schaft DWJ, Wiercinska E, Gorter A, Hogendoorn PCW, Griffioen AW, ten Dijke P. Critical role of endoglin in tumor cell plasticity of Ewing sarcoma and melanoma. Oncogene 2011-Jan-31;30(3):334-345. (pubmed)
  98. Meulmeester E, ten Dijke P. The dynamic roles of TGF-beta in cancer. Journal of pathology 2011-Jan-31;223(2):205-218. (pubmed)
  99. Groenendijk BCW, Benus GFJD, Klous A, Pacheco YM, Volger OL, Fledderus JO, Ferreira V, Engelse MA, Pannekoek H, ten Dijke P, Horrevoets AJG, de Vries CJM. Activin A induces a non-fibrotic phenotype in smooth muscle cells in contrast to TGF-beta. Experimental cell research 2011-Jan-15;317(2):131-142. (pubmed)
  100. Kuiper P, Hawinkels LJAC, de Jonge-Muller ESM, Biemond I, Lamers CBHW, Verspaget HW. Angiogenic markers endoglin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine tumors. World journal of gastroenterology 2011-Jan-14;17(2):219-225. (pubmed)
  101. de Gorter DJJ, van Dinther M, ten Dijke P. MEASUREMENT OF CONSTITUTIVE ACTIVITY OF BMP TYPE I RECEPTORS. Methods in enzymology, volume 484: constitutive activity in receptors and o 2010-Dec-31;484:281-293. (pubmed)
  102. Post S, Goumans MJ, Doevendans PA. Peripheral Blood Derived Cell Trafficking for Cardiac Regeneration. Current stem cell research & therapy 2010-Dec-31;5(4):303-313. (pubmed)
  103. Krause C, Korchynskyi O, de Rooij K, Weidauer SE, de Gorter DJ, van Bezooijen RL, Hatsell S, Economides AN, Mueller TD, Löwik CW, ten Dijke P. Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways.. The journal of biological chemistry 2010-Dec-31;285(53):-26. (pubmed)
  104. Heni M, Ketterer C, 't Hart LM, Ranta F, van Haeften TW, Eekhoff EM, Dekker JM, Boomsma DI, Nijpels G, Kramer MH, Diamant M, Simonis-Bik AM, Heine RJ, de Geus EJ, Schafer SA, Machicao F, Ullrich S, Thamer C, Stefan N, Staiger H, Haring HU, Fritsche A. The Impact of Genetic Variation in the G6PC2 Gene on Insulin Secretion Depends on Glycemia. Journal of clinical endocrinology & metabolism 2010-Dec-31;95(12). (pubmed)
  105. Roukens MG, Alloul-Ramdhani M, Baan B, Kobayashi K, Peterson-Maduro J, van Dam H, Schulte-Merker S, Baker DA. Control of endothelial sprouting by a Tel-CtBP complex. Nature cell biology 2010-Oct-31;12(10):933-942. (pubmed)
  106. Ramos YFM, Hestand MS, Verlaan M, Krabbendam E, Ariyurek Y, van Galen M, van Dam H, van Ommen GJB, den Dunnen JT, Zantema A, 't Hoen PAC. Genome-wide assessment of differential roles for p300 and CBP in transcription regulation. Nucleic acids research 2010-Sep-30;38(16):5396-5408. (pubmed)
  107. Pardali E, Goumans MJ, ten Dijke P. Signaling by members of the TGF-beta family in vascular morphogenesis and disease. Trends in cell biology 2010-Sep-30;20(9):556-567. (pubmed)
  108. Oerlemans MIFJ, Goumans MJ, van Middelaar B, Clevers H, Doevendans PA, Sluijter JPG. Active Wnt signaling in response to cardiac injury. Basic research in cardiology 2010-Sep-30;105(5):631-641. (pubmed)
  109. Kaijzel EL, van Heijningen PM, Wielopolski PA, Vermeij M, Koning GA, van Cappellen WA, Que I, Chan A, Dijkstra J, Ramnath NWM, Hawinkels LJAC, Bernsen MR, Lowik CWGM, Essers J. Multimodality Imaging Reveals a Gradual Increase in Matrix Metalloproteinase Activity at Aneurysmal Lesions in Live Fibulin-4 Mice. Circulation-cardiovascular imaging 2010-Sep-30;3(5):567-577. (pubmed)
  110. Hassane S, Leonhard WN, van der Wal A, Hawinkels LJAC, Lantinga-van Leeuwen IS, ten Dijke P, Breuning MH, de Heer E, Peters DJM. Elevated TGF beta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease. Journal of pathology 2010-Sep-30;222(1):21-31. (pubmed)
  111. Bot PT, Pasterkamp G, Goumans MJ, Strijder C, Moll FL, de Vries JP, Pals ST, de Kleijn DP, Piek JJ, Hoefer IE. Hyaluronic acid metabolism is increased in unstable plaques. European journal of clinical investigation 2010-Sep-30;40(9):818-827. (pubmed)
  112. Baan B, Pardali E, ten Dijke P, van Dam H. In Situ Proximity Ligation Detection of c-Jun/AP-1 Dimers Reveals Increased Levels of c-Jun/Fra1 Complexes in Aggressive Breast Cancer Cell Lines in Vitro and in Vivo. Molecular & cellular proteomics 2010-Sep-30;9(9):1982-1990. (pubmed)
  113. Westerweel PE, van Velthoven CTJ, Nguyen TQ, den Ouden K, de Kleijn DPV, Goumans MJ, Goldschmeding R, Verhaar MC. Modulation of TGF-beta/BMP-6 expression and increased levels of circulating smooth muscle progenitor cells in a type I diabetes mouse model. Cardiovascular diabetology 2010-Sep-21;9. (pubmed)
  114. Smits AM, Ramkisoensing AA, Atsma DE, Goumans MJ. Young at heart. An update on cardiac regeneration. Minerva medica 2010-Aug-31;101(4):255-269. (pubmed)
  115. Lapauw B, Ouwens M, 't Hart LM, Wuyts B, Holst JJ, T'Sjoen G, Kaufman JM, Ruige JB. Sex Steroids Affect Triglyceride Handling, Glucose-Dependent Insulinotropic Polypeptide, and Insulin Sensitivity. Diabetes care 2010-Aug-31;33(8):1831-1833. (pubmed)
  116. Bluyssen HAR, Rastmanesh MM, Tilburgs C, Jie K, Wesseling S, Goumans MJ, Boer P, Joles JA, Braam B. IFN gamma-dependent SOCS3 expression inhibits IL-6-induced STAT3 phosphorylation and differentially affects IL-6 mediated transcriptional responses in endothelial cells. American journal of physiology-cell physiology 2010-Aug-31;299(2). (pubmed)
  117. Bax NAM, Bleyl SB, Gallini R, Wisse LJ, Hunter J, Van Oorschot AAM, Mahtab EAF, Lie-Venema H, Goumans MJ, Betsholtz C, Gittenberger-de Groot AC. Cardiac Malformations in Pdgfr alpha Mutant Embryos Are Associated With Increased Expression of WT1 and Nkx2.5 in the Second Heart Field. Developmental dynamics 2010-Aug-31;239(8):2307-2317. (pubmed)
  118. Matic I, Schimmel J, Hendriks IA, van Santen MA, van de Rijke F, van Dam H, Gnad F, Mann M, Vertegaal ACO. Site-Specific Identification of SUMO-2 Targets in Cells Reveals an Inverted SUMOylation Motif and a Hydrophobic Cluster SUMOylation Motif. Molecular cell 2010-Aug-27;39(4):641-652. (pubmed)
  119. van Vliet P, de Boer TP, van der Heyden MAG, El Tamer MK, Sluijter JPG, Doevendans PA, Goumans MJ. Hyperpolarization Induces Differentiation in Human Cardiomyocyte Progenitor Cells. Stem cell reviews and reports 2010-Jun-30;6(2):178-185. (pubmed)
  120. van Dinther M, Visser N, de Gorter DJJ, Doorn J, Goumans MJ, de Boer J, ten Dijke P. ALK2 R206H Mutation Linked to Fibrodysplasia Ossificans Progressiva Confers Constitutive Activity to the BMP Type I Receptor and Sensitizes Mesenchymal Cells to BMP-Induced Osteoblast Differentiation and Bone Formation. Journal of bone and mineral research 2010-Jun-30;25(6):1208-1215. (pubmed)
  121. Van Oorschot AAM, Smits AM, Goumans MJ. Stem cells: the building blocks to repair the injured heart. Panminerva medica 2010-Jun-30;52(2):97-110. (pubmed)
  122. Nascimento EBM, Snel M, Guigas B, van der Zon GCM, Kriek J, Maassen JA, Jazet IM, Diamant M, Ouwens DM. Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1. Cellular signalling 2010-Jun-30;22(6):961-967. (pubmed)
  123. van Weenen JED, Parlevliet ET, Maechler P, Havekes LM, Romijn JA, Ouwens DM, Pijl H, Guigas B. The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the alpha 2-adrenergic receptors in beta cells. Biochemical pharmacology 2010-Jun-15;79(12):1827-1836. (pubmed)
  124. Hawinkels LJAC, Kuiper P, Wiercinska E, Verspaget HW, Liu Z, Pardali E, Sier CFM, ten Dijke P. Matrix Metalloproteinase-14 (MT1-MMP)-Mediated Endoglin Shedding Inhibits Tumor Angiogenesis. Cancer research 2010-May-15;70(10):4141-4150. (pubmed)
  125. van Vliet P, Smits AM, de Boer TP, Korfage TH, Metz CHG, Roccio M, van der Heyden MAG, van Veen TAB, Sluijter JPG, Doevendans PA, Goumans MJ. Foetal and adult cardiomyocyte progenitor cells have different developmental potential. Journal of cellular and molecular medicine 2010-Apr-30;14(4):861-870. (pubmed)
  126. Sluijter JPG, van Mil A, van Vliet P, Metz CHG, Liu J, Doevendans PA, Goumans MJ. MicroRNA-1 and-499 Regulate Differentiation and Proliferation in Human-Derived Cardiomyocyte Progenitor Cells. Arteriosclerosis thrombosis and vascular biology 2010-Apr-30;30(4):859. (pubmed)
  127. Reiling E, Ling C, Uitterlinden AG, van't Riet E, Welschen LMC, Ladenvall C, Almgren P, Lyssenko V, Nijpels G, van Hove EC, Maassen JA, de Geus EJC, Boomsma DI, Dekker JM, Groop L, Willemsen G, 't Hart LM. The Association of Mitochondrial Content with Prevalent and Incident Type 2 Diabetes. Journal of clinical endocrinology & metabolism 2010-Apr-30;95(4):1909-1915. (pubmed)
  128. Song KN, Krause C, Shi ST, Patterson M, Suto R, Grgurevic L, Vukicevic S, van Dinther M, Falb D, ten Dijke P, Alaoui-Ismaili MH. Identification of a Key Residue Mediating Bone Morphogenetic Protein (BMP)-6 Resistance to Noggin Inhibition Allows for Engineered BMPs with Superior Agonist Activity. Journal of biological chemistry 2010-Apr-16;285(16). (pubmed)
  129. Hagberg CE, Falkevall A, Wang X, Larsson E, Huusko J, Nilsson I, van Meeteren LA, Samen E, Lu L, Vanwildemeersch M, Klar J, Genove G, Pietras K, Stone-Elander S, Claesson-Welsh L, Yla-Herttuala S, Lindahl P, Eriksson U. Vascular endothelial growth factor B controls endothelial fatty acid uptake. Nature 2010-Apr-08;464(7290):917. (pubmed)
  130. de Graauw M, van Miltenburg MH, Schmidt MK, Pont C, Lalai R, Kartopawiro J, Pardali E, Le Devedec SE, Smit VT, van der Wal A, Van't Veer LJ, Cleton-Jansen AM, ten Dijke P, van de Water B. Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells. Proceedings of the national academy of sciences of the united states of ame 2010-Apr-06;107(14):6340-6345. (pubmed)
  131. Morais AD, Abarca-Quinones J, Guigas B, Viollet B, Starkel P, Horsmans Y, Leclercq IA. Development of hepatic fibrosis occurs normally in AMPK-deficient mice. Clinical science 2010-Mar-31;118(5-6):411-420. (pubmed)
  132. van den Berg SAA, Guigas B, Bijland S, Ouwens M, Voshol PJ, Frants RR, Havekes LM, Romijn JA, van Dijk KW. High levels of dietary stearate promote adiposity and deteriorate hepatic insulin sensitivity. Nutrition & metabolism 2010-Mar-27;7. (pubmed)
  133. Petersen M, Pardali E, van der Horst G, Cheung H, van den Hoogen C, van der Pluijm G, ten Dijke P. Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis. Oncogene 2010-Mar-04;29(9):1351-1361. (pubmed)
  134. Engelen L, Ferreira I, Gaens KHJ, Henry RMA, Dekker JM, Nijpels G, Heine RJ, 't Hart LM, van Greevenbroek MMJ, van der Kallen CJH. The association between the-374T/A polymorphism of the receptor for advanced glycation endproducts gene and blood pressure and arterial stiffness is modified by glucose metabolism status: the Hoorn and CoDAM studies. Journal of hypertension 2010-Feb-28;28(2):285-293. (pubmed)
  135. Tian F, Zhou AX, Smits AM, Larsson E, Goumans MJ, Heldin CH, Boren J, Akyurek LM. Endothelial cells are activated during hypoxia via endoglin/ALK-1/SMAD1/5 signaling in vivo and in vitro. Biochemical and biophysical research communications 2010-Feb-12;392(3):283-288. (pubmed)
  136. Post S, Smits AM, van den Broek AJ, Sluijter JPG, Hoefer IE, Janssen BJ, Snijder RJ, Mager JJ, Pasterkamp G, Mummery CL, Doevendans PA, Goumans MJ. Impaired recruitment of HHT-1 mononuclear cells to the ischaemic heart is due to an altered CXCR4/CD26 balance. Cardiovascular research 2010-Feb-01;85(3):494-502. (pubmed)
  137. de Boer TP, van Veen TAB, Jonsson MKB, Kok BGJM, Metz CHG, Sluijter JPG, Doevendans PA, de Bakker JMT, Goumans MJ, van der Heyden MAG. Human cardiomyocyte progenitor cell-derived cardiomyocytes display a maturated electrical phenotype. Journal of molecular and cellular cardiology 2010-Jan-31;48(1):254-260. (pubmed)
  138. Simonis-Bik AM, Nijpels G, van Haeften TW, Houwing-Duistermaat JJ, Boomsma DI, Reiling E, van Hove EC, Diamant M, Kramer MHH, Heine RJ. Gene Variants in the Novel Type 2 Diabetes Loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B Affect Different Aspects of Pancreatic beta-Cell Function. Diabetes 2010-Jan-31;59(1):293-301. (pubmed)
  139. Reiling E, Jafar-Mohammadi B, van't Riet E, Weedon MN, van Vliet-Ostaptchouk JV, Hansen T, Saxena R, van Haeften TW, Arp PA, Das S. Genetic association analysis of LARS2 with type 2 diabetes. Diabetologia 2010-Jan-31;53(1):103-110. (pubmed)
  140. 't Hart LM, Simonis-Bik AM, Nijpels G, van Haeften TW, Schafer SA, Houwing-Duistermaat JJ, Boomsma DI, Groenewoud MJ, Reiling E, van Hove EC. Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First-Phase Glucose-Stimulated Insulin Secretion During Hyperglycemic Clamps. Diabetes 2010-Jan-31;59(1):287-292. (pubmed)
  141. Cunha SI, Pardali E, Thorikay M, Anderberg C, Hawinkels L, Goumans MJ, Seehra J, Heldin CH, ten Dijke P, Pietras K. Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis. Journal of experimental medicine 2010-Jan-18;207(1):85-100. (pubmed)
  142. Watanabe Y, Itoh S, Goto T, Ohnishi E, Inamitsu M, Itoh F, Satoh K, Wiercinska E, Yang WW, Shi L. TMEPAI, a Transmembrane TGF-beta-Inducible Protein, Sequesters Smad Proteins from Active Participation in TGF-beta Signaling. Molecular cell 2010-Jan-15;37(1):123-134. (pubmed)
  143. Koelink PJ, Hawinkels LJAC, Wiercinska E, Sier CFM, ten Dijke P, Lamers CBHW, Hommes DW, Verspaget HW. 5-Aminosalicylic acid inhibits TGF-beta 1 signalling in colorectal cancer cells. Cancer letters 2010-Jan-01;287(1):82-90. (pubmed)
  144. Smits AM, van Vliet P, Metz CH, Korfage T, Sluijter JPG, Doevendans PA, Goumans MJ. Human cardiomyocyte progenitor cells differentiate into functional mature cardiomyocytes: an in vitro model for studying human cardiac physiology and pathophysiology. Nature protocols 2009-Dec-31;4(2):232-243. (pubmed)
  145. Simonis-Bik AMC, Eekhoff EMW, de Moor MHM, Kramer MHH, Boomsma DI, Heine RJ, Dekker JM, Maassen JA, 't Hart LM, Diamant M. Genetic influences on the insulin response of the beta cell to different secretagogues. Diabetologia 2009-Dec-31;52(12):2570-2577. (pubmed)
  146. Mesker WE, Liefers GJ, Junggeburt JMC, van Pelt GW, Alberici P, Kuppen PJK, Miranda NF, van Leeuwen KAM, Morreau H, Szuhai K. Presence of a high amount of stroma and downregulation of SMAD4 predict for worse survival for stage I-II colon cancer patients. Cellular oncology 2009-Dec-31;31(3):169-178. (pubmed)
  147. Hsiao HH, Meulmeester E, Frank BTC, Melchior F, Urlaub H. "ChopNSpice," a Mass Spectrometric Approach That Allows Identification of Endogenous Small Ubiquitin-like Modifier-conjugated Peptides. Molecular & cellular proteomics 2009-Dec-31;8(12):2664-2675. (pubmed)
  148. Haas SL, Fitzner B, Jaster R, Wiercinska E, Gaitantzi H, Jesenowski R, Lohr JM, Singer MV, Dooley S, Breitkopf K. Transforming growth factor- induces nerve growth factor expression in pancreatic stellate cells by activation of the ALK-5 pathway. Growth factors 2009-Dec-31;27(5):289-299. (pubmed)
  149. Gaens KHJ, Ferreira I, van der Kallen CJH, van Greevenbroek MMJ, Blaak EE, Feskens EJM, Dekker JM, Nijpels G, Heine RJ, 't Hart LM. Association of Polymorphism in the Receptor for Advanced Glycation End Products (RAGE) Gene with Circulating RAGE Levels. Journal of clinical endocrinology & metabolism 2009-Dec-31;94(12):5174-5180. (pubmed)
  150. Herrera B, van Dinther M, ten Dijke P, Inman GJ. Autocrine Bone Morphogenetic Protein-9 Signals through Activin Receptor-like Kinase-2/Smad1/Smad4 to Promote Ovarian Cancer Cell Proliferation. Cancer research 2009-Dec-15;69(24):9254-9262. (pubmed)
  151. Winter EM, van Oorschot AAM, Hogers B, van der Graaf LM, Doevendans PA, Poelmann RE, Atsma DE, Gittenberger-de Groot AC, Goumans MJ. A New Direction for Cardiac Regeneration Therapy Application of Synergistically Acting Epicardium-Derived Cells and Cardiomyocyte Progenitor Cells. Circulation-heart failure 2009-Nov-30;2(6):643-653. (pubmed)
  152. Baan B, van der Zon GCM, Maassen JA, Ouwens DM. The nuclear appearance of ERK1/2 and p38 determines the sequential induction of ATF2-Thr71 and ATF2-Thr69 phosphorylation by serum in JNK-deficient cells. Molecular and cellular endocrinology 2009-Nov-13;311(1-2):94-100. (pubmed)
  153. Nascimento EB, Ouwens DM. PRAS40: target or modulator of mTORC1 signalling and insulin action?. Archives of physiology and biochemistry 2009-Oct-31;115(4). (pubmed)
  154. Scharpfenecker M, Floot B, Russell NS, ten Dijke P, Stewart FA. Endoglin haploinsufficiency reduces radiation-induced fibrosis and telangiectasia formation in mouse kidneys. Radiotherapy and oncology 2009-Sep-30;92(3):484-491. (pubmed)
  155. Reiling E, van't Riet E, Groenewoud MJ, Welschen LMC, van Hove EC, Nijpels G, Maassen JA, Dekker JM, 't Hart LM. Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk. Diabetologia 2009-Sep-30;52(9):1866-1870. (pubmed)
  156. Liu Z, Kobayashi K, van Dinther M, van Heiningen SH, Valdimarsdottir G, van Laar T, Scharpfenecker M, Lowik CWGM, Goumans MJ, ten Dijke P. VEGF and inhibitors of TGF beta type-I receptor kinase synergistically promote blood-vessel formation by inducing alpha 5-integrin expression. Journal of cell science 2009-Sep-15;122(18):3294-3302. (pubmed)
  157. Reiling E, van Vliet-Ostaptchouk JV, van't Riet E, van Haeften TW, Arp PA, Hansen T, Kremer D, Groenewoud MJ, van Hove EC, Romijn JA. Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. European journal of human genetics 2009-Aug-31;17(8):1056-1062. (pubmed)
  158. Dzwonek J, Preobrazhenska O, Cazzola S, Conidi A, Schellens A, van Dinther M, Stubbs A, Klippel A, Huylebroeck D, ten Dijke P. Smad3 Is a Key Nonredundant Mediator of Transforming Growth Factor beta Signaling in Nme Mouse Mammary Epithelial Cells. Molecular cancer research 2009-Aug-31;7(8):1342-1353. (pubmed)
  159. Smits AM, van Laake LW, den Ouden K, Schreurs C, Szuhai K, van Echteld CJ, Mummery CL, Doevendans PA, Goumans MJ. Human cardiomyocyte progenitor cell transplantation preserves long-term function of the infarcted mouse myocardium. Cardiovascular research 2009-Aug-01;83(3):527-535. (pubmed)
  160. Noort WA, Sluijter JPG, Goumans MJ, Chamuleau SAJ, Doevendans PA. Stem Cells from In- or Outside of the Heart: Isolation, Characterization, and Potential for Myocardial Tissue Regeneration. Pediatric cardiology 2009-Jul-31;30(5):699-709. (pubmed)
  161. Itoh F, Itoh S, Carvalho RLC, Adachi T, Ema M, Goumans MJ, Larsson J, Karlsson S, Takahashi S, Mummery CL. Poor vessel formation in embryos from knock-in mice expressing ALK5 with L45 loop mutation defective in Smad activation. Laboratory investigation 2009-Jul-31;89(7):800-810. (pubmed)
  162. van den Brom CE, Huisman MC, Vlasblom R, Boontje NM, Duijst S, Lubberink M, Molthoff CFM, Lammertsma AA, van der Velden J, Boer C. Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography. Cardiovascular diabetology 2009-Jul-22;8. (pubmed)
  163. Verschuren L, Kooistra T, Bernhagen J, Voshol PJ, Ouwens DM, van Erk M, de Vries-van der Weij J, Leng L, van Bockel JH, van Dijk KW. MIF Deficiency Reduces Chronic Inflammation in White Adipose Tissue and Impairs the Development of Insulin Resistance, Glucose Intolerance, and Associated Atherosclerotic Disease. Circulation research 2009-Jul-02;105(1):99. (pubmed)
  164. Pardali E, ten Dijke P. Transforming growth factor-beta signaling and tumor angiogenesis. Frontiers in bioscience 2009-Jun-30;14:4848-4861. (pubmed)
  165. Smith KA, Joziasse IC, Chocron S, van Dinther M, Guryev V, Verhoeven MC, Rehmann H, van der Smagt JJ, Doevendans PA, Cuppen E. Dominant-Negative ALK2 Allele Associates With Congenital Heart Defects. Circulation 2009-Jun-23;119(24):3062. (pubmed)
  166. Davidson ENB, Remst DFG, Vitters EL, van Beuningen HM, Blom AB, Goumans MJ, van den Berg WB, van der Kraan PM. Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice. Journal of immunology 2009-Jun-15;182(12):7937-7945. (pubmed)
  167. Viollet B, Guigas B, Leclerc J, Hebrard S, Lantier L, Mounier R, Andreelli F, Foretz M. AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives. Acta physiologica 2009-May-31;196(1):81-98. (pubmed)
  168. Luiken JJFP, Omens DM, Habets DDJ, van der Zon GCM, Coumans WA, Schwenk RW, Bonen A, Glatz JFC. Permissive action of protein kinase C-zeta in insulin-induced CD36-and GLUT4 translocation in cardiac myocytes. Journal of endocrinology 2009-May-31;201(2):199-209. (pubmed)
  169. Liu J, Sluijter JPG, Goumans MJ, Smits AM, van der Spoel T, Nathoe H, Doevendans PA. Cell Therapy for Myocardial Regeneration. Current molecular medicine 2009-Apr-30;9(3):287-298. (pubmed)
  170. Jonsson MKB, van Veen TAB, Goumans MJ, Vos MA, Duker G, Sartipy P. Improvement of cardiac efficacy and safety models in drug discovery by the use of stem cell-derived cardiomyocytes. Expert opinion on drug discovery 2009-Apr-30;4(4):357-372. (pubmed)
  171. Smits AM, van den Hengel LG, van den Brink S, Metz CH, Doevendans PA, Goumans MJ. A new in vitro model for stem cell differentiation and interaction. Stem cell research 2009-Mar-31;2(2):108-112. (pubmed)
  172. Schrage YM, Hameetman L, Szuhai K, Cleton-Jansen AM, Taminiau AHM, Hogendoorn PCW, Bovee JVMG. Aberrant Heparan Sulfate Proteoglycan Localization, Despite Normal Exostosin, in Central Chondrosarcoma. American journal of pathology 2009-Mar-31;174(3):979-988. (pubmed)
  173. Morais ADS, Lebrun V, Abarca-Quinones J, Brichard S, Hue L, Guigas B, Viollet B, Leclercq IA. Prevention of steatohepatitis by pioglitazone: Implication of adiponectin-dependent inhibition of SREBP-1c and inflammation. Journal of hepatology 2009-Mar-31;50(3):489-500. (pubmed)
  174. van Raalte DH, Ouwens DM, Diamant M. Novel insights into glucocorticoid-mediated diabetogenic effects: towards expansion of therapeutic options?. European journal of clinical investigation 2009-Feb-28;39(2):81-93. (pubmed)
  175. Janssen GMC, Schwertman P, Wanga TAT, Tafrechi RSJ, van den Broek PJA, Raap AK. Transient and constitutive repression of cytoplasmic translation signaling in cells with mtDNA mutation. Cellular and molecular life sciences 2009-Feb-28;66(4):721-730. (pubmed)
  176. Bot PTG, Hoefer IE, Sluijter JPG, van Vliet P, Smits AM, Lebrin F, Moll F, de Vries JP, Doevendans P, Piek JJ, Pasterkamp G, Goumans MJ. Increased Expression of the Transforming Growth Factor-beta Signaling Pathway, Endoglin, and Early Growth Response-1 in Stable Plaques. Stroke 2009-Feb-28;40(2):439-447. (pubmed)
  177. Scharpfenecker M, Kruse JJCM, Sprong D, Russell NS, Dijke PT, Stewart FA. IONIZING RADIATION SHIFTS THE PAI-1/ID-1 BALANCE AND ACTIVATES NOTCH SIGNALING IN ENDOTHELIAL CELLS. International journal of radiation oncology biology physics 2009-Feb-01;73(2):506-513. (pubmed)
  178. van Elderen SGC, Doornbos J, van Essen EHR, Lemkes HHPJ, Maassen JA, Smit JWA, de Roos A. Phosphorus-31 Magnetic Resonance Spectroscopy of Skeletal Muscle in Maternally Inherited Diabetes and Deafness A3243G Mitochondrial Mutation Carriers. Journal of magnetic resonance imaging 2009-Jan-31;29(1):127-131. (pubmed)
  179. Tabata T, Kokura K, ten Dijke P, Ishii S. Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5. Genes to cells 2009-Jan-31;14(1):17-28. (pubmed)
  180. Jaakkola U, Kallio J, Heine RJ, Nijpels G, t'Hart LM, Maassen JA, Bouter LM, Stehouwer CDA, Dekker JM. Neuropeptide Y polymorphism significantly magnifies diabetes and cardiovascular disease risk in obesity: the Hoorn Study. European journal of clinical nutrition 2009-Jan-31;63(1):150-152. (pubmed)
  181. Guigas B, Sakamoto K, Taleux N, Reyna SM, Musi N, Viollet B, Hue L. Beyond AICA Riboside: In Search of New Specific AMP-activated Protein Kinase Activators. Iubmb life 2009-Jan-31;61(1):18-26. (pubmed)
  182. Goumans MJ, Liu Z, ten Dijke P. TGF-beta signaling in vascular biology and dysfunction. Cell research 2009-Jan-31;19(1):116-127. (pubmed)
  183. Viollet B, Athea Y, Mounier R, Guigas B, Zarrinpashneh E, Horman S, Lantier L, Hebrard S, Devin-Leclerc J, Beauloye C. AMPK: Lessons from transgenic and knockout animals. Frontiers in bioscience-landmark 2009-Jan-01;14:19-44. (pubmed)
  184. Naber HPH, ten Dijke P, Pardali E. Role of TGF-beta in the Tumor Stroma. Current cancer drug targets 2008-Dec-31;8(6):466-472. (pubmed)
  185. Hawinkels L, Goumans M, ten Dijke P. TGF-beta Receptor Signal Transduction in Vascular Development. Iccb 2008: proceedings of the 9th international congress on cell biology 2008-Dec-31;:1-6. (pubmed)
  186. Goumans MJ, van Zonneveld AJ, ten Dijke P. Transforming Growth Factor beta-Induced Endothelial-to-Mesenchymal Transition: A Switch to Cardiac Fibrosis?. Trends in cardiovascular medicine 2008-Nov-30;18(8):293-298. (pubmed)
  187. van den Hoek AM, van Heijningen C, der Elst JPSV, Ouwens DM, Havekes LM, Romijn JA, Kalsbeek A, Pijl H. Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation. Diabetes 2008-Sep-30;57(9):2304-2310. (pubmed)
  188. Groenewoud MJ, Dekker JM, Fritsche A, Reiling E, Nijpels G, Heine RJ, Maassen JA, Machicao F, Schafer SA, Haring HU, 't Hart LM, van Haeften TW. Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps. Diabetologia 2008-Sep-30;51(9):1659-1663. (pubmed)
  189. Pannu J, Asano Y, Nakerakanti S, Smith E, Jablonska S, Blaszczyk M, ten Dijke P, Trojanowska M. Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate. Arthritis and rheumatism 2008-Aug-31;58(8):2528-2537. (pubmed)
  190. Diefenbacher M, Sekula S, Heilbock C, Maier JV, Litfin M, van Dam H, Castellazzi M, Herrlich P, Kassel O. Restriction to fos family members of Trip6-dependent coactivation and glucocorticoid receptor-dependent trans-repression of activator protein-1. Molecular endocrinology 2008-Aug-31;22(8):1767-1780. (pubmed)
  191. Finnson KW, Parker WL, ten Dijke P, Thorikay M, Philip A. ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes. Journal of bone and mineral research 2008-Jun-30;23(6):896-906. (pubmed)
  192. Maassen JA, Romijn JA, Heine RJ. Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: do adipocytes consume sufficient amounts of oxygen to oxidise fatty acids?. Diabetologia 2008-May-31;51(5):907-908. (pubmed)
  193. Kodach LL, Wiercinska E, De Miranda NFCC, Bleuming SA, Musler AR, Peppelenbosch MP, Dekker E, van den Brink GR, Van Noesel CJM, Morreau H, Hommes DW, Ten Dijke P, Offerhaus GJA, Hardwick JCH. The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers. Gastroenterology 2008-May-31;134(5):1332-1341. (pubmed)
  194. Taleux N, De Potter I, Deransart C, Lacraz G, Favier R, Leverve XM, Hue L, Guigas B. Lack of starvation-induced activation of AMP-activated protein kinase in the hypothalamus of the Lou/C rats resistant to obesity. International journal of obesity 2008-Apr-30;32(4):639-647. (pubmed)
  195. Rudini N, Felici A, Giampietro C, Lampugnani M, Corada M, Swirsding K, Garre M, Liebner S, Letarte M, ten Dijke P, Dejana E. VE-cadherin is a critical endothelial regulator of TGF-beta signalling. Embo journal 2008-Apr-09;27(7):993-1004. (pubmed)
  196. ten Dijke P, Goumans MJ, Pardali E. Endoglin in angiogenesis and vascular diseases. Angiogenesis 2008-Mar-31;11(1):79-89. (pubmed)
  197. Petersen M, Thorikay M, Deckers M, van Dinther M, Grygielko ET, Gellibert F, de Gouville A, Huet S, ten Dijke P, Laping N. Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis. Kidney international 2008-Mar-31;73(6):705-715. (pubmed)
  198. Velasco S, Alvarez-Munoz P, Pericacho M, ten Dijke P, Bernabeu C, Lopez-Novoa JM, Rodriguez-Barbero A. L- and S-endoglin differentially modulate TGF beta 1 signaling mediated by ALK1 and ALK5 in L6E9 myoblasts. Journal of cell science 2008-Mar-15;121(6):913-919. (pubmed)
  199. Monteiro R, van Dinther M, Bakkers J, Wilkinson R, Patient R, ten Dijke P, Mummery C. Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish. Developmental biology 2008-Mar-01;315(1):55-71. (pubmed)
  200. Hamdi M, Popeijus HE, Carlotti F, Janssen JM, van der Burgt C, Cornelissen-Steijger P, van de Water BV, Hoeben RC, Matsuo K, van Dam H. ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responses. Dna repair 2008-Mar-01;7(3):487-496. (pubmed)
  201. ten Dijke P, Krause C, de Gorter DJJ, Lowik CWGM, van Bezooijen RL. Osteocyte-derived sclerostin inhibits bone formation: Its role in bone morphogenetic protein and Wnt signaling. Journal of bone and joint surgery-american volume 2008-Feb-28;90A:31-35. (pubmed)
  202. Jazet IM, Schaart G, Gastaldelli A, Ferrannini E, Hesselink MK, Schrauwen P, Romijn JA, Maassen JA, Pijl H, Ouwens DM, Meinders AE. Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients. Diabetologia 2008-Feb-28;51(2):309-319. (pubmed)
  203. Timmers L, Sluijter JPG, van Keulen JK, Hoefer IE, Nederhoff MGJ, Goumans MJ, Doevendans PA, van Echteld CJA, Joles JA, Quax PH, Piek JJ, Pasterkamp G, de Kleijn DPV. Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction. Circulation research 2008-Feb-01;102(2):257-264. (pubmed)
  204. Huisman MA, de Heer E, Ten Dijke P, Grote JJ. Transforming Growth Factor beta and Wound Healing in Human Cholesteatoma. Laryngoscope 2008-Jan-31;118(1):94-98. (pubmed)
  205. Schafer SA, Tschritter O, Machicao F, Thamer C, Stefan N, Gallwitz B, Holst JJ, Dekker JM, t'Hart LM, Nijpels G, van Haeften TW, Haring HU, Fritsche A. Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Diabetologia 2007-Dec-31;50(12):2443-2450. (pubmed)
  206. Eichhorn PJA, Creyghton MP, Wilhelmsen K, van Dam H, Bernards R. A RNA interference screen identifies the protein phosphatase 2A subunit PR55 gamma as a stress-sensitive inhibitor of c-SRC. Plos genetics 2007-Dec-31;3(12):2381-2394. (pubmed)
  207. Al-Ramahi I, Perez AM, Lim J, Zhang MH, Sorensen R, de Haro M, Branco J, Pulst SM, Zoghbi HY, Botas J. DAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1. Plos genetics 2007-Dec-31;3(12):2551-2564. (pubmed)
  208. Carvalho RLC, Itoh F, Goumans MJ, Lebrin F, Kato M, Takahashi S, Ema M, Itoh S, van Rooijen M, Bertolino P, ten Dijke P, Mummery CL. Compensatory signalling induced in the yolk sac vasculature by deletion of TGF beta receptors in mice. Journal of cell science 2007-Dec-15;120(24):4269-4277. (pubmed)
  209. ten Dijke P, Arthur HM. Extracellular control of TGF beta signalling in vascular development and disease. Nature reviews molecular cell biology 2007-Nov-30;8(11):857-869. (pubmed)
  210. Tafrechi RSJ, van de Rijke FM, Allallou A, Larsson C, Sloos WCR, van de Sande M, Wahlby C, Janssen GMC, Raap AK. Single-cell A3243G mitochondrial DNA mutation load assays for segregation analysis. Journal of histochemistry & cytochemistry 2007-Nov-30;55(11):1159-1166. (pubmed)
  211. Maassen JA, 't Hart LM, Ouwens DM. Lessons that can be learned from patients with diabetogenic mutations in mitochondrial DNA: Implications for common type 2 diabetes. Current opinion in clinical nutrition and metabolic care 2007-Nov-30;10(6):693-697. (pubmed)
  212. Buijs JT, Henriquez NV, van Overveld PGM, van der Horst G, ten Dijke P, van der Pluijm G. TGF-beta and BMP7 interactions in tumour progression and bone metastasis. Clinical & experimental metastasis 2007-Nov-30;24(8):609-617. (pubmed)
  213. Maassen JA, Romijn JA, Heine RJ. Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: a new concept in the pathogenesis of obesity-associated type 2 diabetes mellitus. Diabetologia 2007-Oct-31;50(10):2036-2041. (pubmed)
  214. Janssen GMC, Hensbergen PJ, van Bussel FJ, Balog CIA, Maassen JA, Deelder AM, Raap AK. The A3243G tRNA(Leu(UUR)) mutation induces mitochondrial dysfunction and variable disease expression without dominant negative acting translational defects in complex IV subunits at UUR codons. Human molecular genetics 2007-Oct-15;16(20):2472-2481. (pubmed)
  215. Ouwens DM, Diamant M, Fodor M, Habets DDJ, Pelsers MMAL, El Hasnaoui M, Dang ZC, van den Brom CE, Vlasblom R, Rietdijk A, Boer C, Coort SLM, Glatz JFC, Luiken JJFP. Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification. Diabetologia 2007-Sep-30;50(9):1938-1948. (pubmed)
  216. Buijs JT, Rentsch CA, van der Horst G, van Civerveld PGM, Wetterwald A, Schwaninger R, Henriquez NV, ten Dijke P, Borovecki F, Markwalder R, Thalmann GN, Papapoulos SE, Pelger RCM, Vukicevic S, Cecchini MG, Lowik CWGM, van der Pluijm G. BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo. American journal of pathology 2007-Sep-30;171(3):1047-1057. (pubmed)
  217. Zilberberg L, ten Dijke P, Sakai LY, Rifkin DB. A rapid and sensitive bioassay to measure bone morphogenetic protein activity. Bmc cell biology 2007-Sep-19;8. (pubmed)
  218. Buijs JT, Henriquez NV, Van Overveld PGM, Van der Horst G, Que I, Schwaninger R, Rentsch C, Ten Dijke P, Cleton-Jansen AM, Driouch K, Lidereau R, Bachelier R, Vukicevic S, Clezardin P, Papapoulos SE, Cecchini MG, Lowik CWGM, Van der Pluijm G. Bone morphogenetic protein 7 in the development and treatment of bone Metastases from breast cancer. Cancer research 2007-Sep-15;67(18):8742-8751. (pubmed)
  219. de Preux AS, Goosen K, Zhang W, Sima AAF, Shimano H, Ouwens DM, Diamant M, Hillebrands JL, Rozing J, Lemke G, Beckmann JS, Smit AB, Verheijen MHG, Chrast R. SRIEBP-1c expression in Schwann cells is affected by diabetes and nutritional status. Molecular and cellular neuroscience 2007-Aug-31;35(4):525-534. (pubmed)
  220. Dennler S, Andre J, Alexaki I, Li A, Magnaldo T, ten Dijke P, Wang XJ, Verrecchia F, Mauviel A. Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. Cancer research 2007-Jul-15;67(14):6981-6986. (pubmed)
  221. Itoh S, ten Dijke P. Negative regulation of TGF-beta receptor/Smad signal transduction. Current opinion in cell biology 2007-Apr-30;19(2):176-184. (pubmed)
  222. Heldin CH, ten Dijke P. Editorial overview: Cellular signaling. Current opinion in cell biology 2007-Apr-30;19(2):109-111. (pubmed)
  223. Pannu J, Nakerakanti S, Smith E, ten Dijke P, Trojanowska M. Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways. Journal of biological chemistry 2007-Apr-06;282(14):10405-10413. (pubmed)
  224. Castanares C, Redondo-Horcajo M, Magan-Marchal N, ten Dijke P, Lamas S, Rodriguez-Pascual F. Signaling by ALK5 mediates TGF-beta-induced ET-1 expression in endothelial cells: a role for migration and proliferation. Journal of cell science 2007-Apr-01;120(7):1256-1266. (pubmed)
  225. Li Y, Ying LT, Ten Dijke P, Chiang C. Aberrant bmp signaling and notochord delamination in the pathogenesis of esophageal atresia. Developmental dynamics 2007-Mar-31;236(3):746-754. (pubmed)
  226. Ciapaite J, Bakker SJL, Van Eikenhorst G, Wagner MJ, Teerlink T, Schalkwijk CG, Fodor M, Ouwens DM, Diamant M, Heine RJ, Westerhoff HV, Krab K. Functioning of oxidative phosphorylation in liver mitochondria of high-fat diet fed rats. Biochimica et biophysica acta-molecular basis of disease 2007-Mar-31;1772(3):307-316. (pubmed)
  227. Boon RA, Fledderus JO, Volger OL, van Wanrooij EJA, Pardali E, Weesie F, Kuiper J, Pannekoek H, ten Dijke P, Horrevoets AJG. KLF2 suppresses TGF-beta signaling in endothelium through induction of Smad7 and inhibition of AP-1. Arteriosclerosis thrombosis and vascular biology 2007-Mar-31;27(3):532-539. (pubmed)
  228. Scharpfenecker M, van Dinther M, Liu Z, van Bezooijen RL, Zhao QH, Pukac L, Lowik CWGM, ten Dijke P. BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis. Journal of cell science 2007-Mar-15;120(6):964-972. (pubmed)
  229. van Bezooijen RL, DeRuiter MC, Vilain N, Monteiro RM, Visser A, van der Wee-Pals L, van Munsteren CJ, Hogendoorn PCW, Aguet M, Mummery CL, Papapoulos SE, Ten Dijke P, Lowik CWGM. SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development. Developmental dynamics 2007-Feb-28;236(2):606-612. (pubmed)
  230. van Bezooijen RL, Svensson JP, Eefting D, Visser A, van der Horst G, Karperien M, Quax PH, Vrieling H, Papapoulos SE, ten Dijke P, Lowik CW. Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation. Journal of bone and mineral research 2007-Jan-31;22(1):19-28. (pubmed)
  231. Nascimento EBM, Fodor M, van der Zon GCM, Jazet IM, Meinders AE, Voshol PJ, Vlasblom R, Baan B, Eckel J, Maassen JA, Diamant M, Ouwens DM. Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats. Diabetes 2006-Dec-31;55(12):3221-3228. (pubmed)
  232. Melke P, Jonsson H, Pardali E, ten Dijke P, Peterson C. A rate equation approach to elucidate the kinetics and robustness of the TGF-beta pathway. Biophysical journal 2006-Dec-31;91(12):4368-4380. (pubmed)
  233. Korsheninnikova E, van der Zon GCM, Voshol PJ, Janssen GM, Havekes LM, Grefhorst A, Kuipers F, Reijngoud DJ, Romijn JA, Ouwens DM, Maassen JA. Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice. Diabetologia 2006-Dec-31;49(12):3049-3057. (pubmed)
  234. Glatz JFC, Bonen A, Ouwens DM, Luiken JJFP. Regulation of sarcolemmal transport of substrates in the healthy and diseased heart. Cardiovascular drugs and therapy 2006-Dec-31;20(6):471-476. (pubmed)
  235. Inamitsu M, Itoh S, Hellman U, ten Dijke P, Kato M. Methylation of Smad6 by protein arginine N-methyltransferase 1. Febs letters 2006-Dec-11;580(28-29):6603-6611. (pubmed)
  236. van Hove EC, Hansen T, Dekker JM, Reiling E, Nijpels G, Jorgensen T, Borch-Johnsen K, Hamid YH, Heine RJ, Pedersen O, Maassen JA, Hart LMT. The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility - The DAMAGE study. Diabetes 2006-Nov-30;55(11):3193-3196. (pubmed)
  237. Wicks SJ, Grocott T, Haros K, Maillard M, ten Dijke P, Chantry A. Reversible ubiquitination regulates the Smad/TGF-beta signalling pathway. Biochemical society transactions 2006-Nov-30;34:761-763. (pubmed)
  238. Maassen JA, Hart LM, Janssen GMC, Reiling E, Romijn JA, Lemkes HH. Mitochondrial diabetes and its lessons for common Type 2 diabetes. Biochemical society transactions 2006-Nov-30;34:819-823. (pubmed)
  239. van Laake LW, van den Driesche S, Post S, Feijen A, Jansen MA, Driessens MH, Mager JJ, Snijder RJ, Westermann CJJ, Doevendans PA, van Echteld CJA, ten Dijke P, Arthur HM, Goumans MJ, Lebrin F, Mummery CL. Endoglin has a crucial role in blood cell-mediated vascular repair. Circulation 2006-Nov-21;114(21):2288-2297. (pubmed)
  240. van Doorn M, Kemme M, Ouwens M, van Hoogdalem EJ, Jones R, Romijn H, de Kam M, Schoemaker R, Burggraaf K, Cohen A. Evaluation of proinflammatory cytokines and inflammation markers as biomarkers for the action of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers. British journal of clinical pharmacology 2006-Oct-31;62(4):391-402. (pubmed)
  241. den Boer MAM, Voshol PJ, Schroder-van der Elst JP, Korsheninnikova E, Ouwens DM, Kuipers F, Havekes LM, Romijn JA. Endogenous interleukin-10 protects against hepatic steatosis but does not improve insulin sensitivity during high-fat feeding in mice. Endocrinology 2006-Oct-31;147(10):4553-4558. (pubmed)
  242. Hendrickx JJ, Mudde AH, t' Hart LM, Huygen PLM, Cremers CWRJ. Progressive sensorineural hearing impairment in maternally inherited diabetes mellitus and deafness (MIDD). Otology & neurotology 2006-Sep-30;27(6):802-808. (pubmed)
  243. Han GW, Li AG, Liang YY, Owens P, He W, Lu SL, Yoshimatsu Y, Wang D, ten Dijke P, Lin X, Wang XJ. Smad7-induced beta-catenin degradation alters epidermal appendage development. Developmental cell 2006-Sep-30;11(3):301-312. (pubmed)
  244. Noda D, Itoh S, Watanabe Y, Inamitsu M, Dennler S, Itoh F, Koike S, Danielpour D, ten Dijke P, Kato M. ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-beta/Smad-induced growth arrest of prostate cells. Oncogene 2006-Sep-14;25(41):5591-5600. (pubmed)
  245. de Andrade PBM, Rubi B, Frigerio F, van den Ouweland JMW, Maassen JA, Maechler P. Diabetes-associated mitochondrial DNA mutation A3243G impairs cellular metabolic pathways necessary for beta cell function. Diabetologia 2006-Aug-31;49(8):1816-1826. (pubmed)
  246. Baan B, van Dam H, van der Zon GCM, Maassen JA, Ouwens DM. The role of c-Jun N-terminal kinase, p38, and extracellular signal-regulated kinase in insulin-induced Thr69 and Thr71 phosphorylation of activating transcription factor 2. Molecular endocrinology 2006-Aug-31;20(8):1786-1795. (pubmed)
  247. Maassen JA, Tafrechi RSJ, Janssen GMC, Raap AK, Lemkes HH, 't Hart LM. New insights in the molecular pathogenesis of the maternally inherited diabetes and deafness syndrome. Endocrinology and metabolism clinics of north america 2006-Jun-30;35(2):385-+. (pubmed)
  248. Wiercinska E, Wickert L, Denecke B, Said HM, Hamzavi J, Gressner AM, Thorikay M, ten Dijke P, Mertens PR, Breitkopf K, Dooley S. Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells. Hepatology 2006-May-31;43(5):1032-1041. (pubmed)
  249. Janssen GMC, Neu A, t'Hart LM, van de Sande CMT, Maassen JA. Novel mitochondrial DNA length variants and genetic instability in a family with diabetes and deafness. Experimental and clinical endocrinology & diabetes 2006-Apr-30;114(4):168-174. (pubmed)
  250. Valdimarsdottir G, Goumans MJ, Itoh F, Itoh S, Heldin CH, ten Dijke P. Smad7 and protein phosphatase 1 alpha are critical determinants in the duration of TGF-beta/ALKI signaling in endothelial cells. Bmc cell biology 2006-Mar-29;7. (pubmed)
  251. Deckers M, van Dinther M, Buijs J, Que N, Lowik C, van der Pluijm G, ten Dijke P. The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells. Cancer research 2006-Feb-15;66(4):2202-2209. (pubmed)
  252. Logeart-Avramoglou D, Bourguignon M, Oudina K, Ten Dijke P, Petite H. An assay for the determination of biologically active bone morphogenetic proteins using cells transfected with an inhibitor of differentiation promoter-luciferase construct. Analytical biochemistry 2006-Feb-01;349(1):78-86. (pubmed)
  253. ten Dijke P. Bone morphogenetic protein signal transduction in bone. Current medical research and opinion 22:S7-S11. (pubmed)
  254. van der Pluijm G, Buijs J, Henriquez N, Wetterwald A, Rentsch C, Schwaninger R, ten Dijke P, Borovecki F, Thalmann G, Pelger R, Cecchini M, Lowik C. Epithelium-mesenchyme transition in bone metastasis: New therapeutic opportunities?. Journal of bone and mineral research 2005-Dec-31;20. (pubmed)
  255. Westerhuis RJ, van Bezooijen RL, Kloen P. Use of bone morphogenetic proteins in traumatology. Injury-international journal of the care of the injured 2005-Dec-31;36(12):1405-1412. (pubmed)
  256. Monraats PS, Pireso NMM, Schepers A, Agema WRP, Boesten LSM, de Vries MR, Zwinderman AH, de Maat MPM, Doevendans PAFM, de Winter RJ, Tio RA, Waltenberger J, 't Hart LM, Frants RR, Quax PHA, van Vlijmen BJM, Havekes LM, van der Laarse A, van der Wall EE, Jukema JW. Tumor necrosis factor-alpha plays an important role in restenosis development. Faseb journal 2005-Dec-31;19(14):1998-2004. (pubmed)
  257. Gardner JC, van Bezooijen RL, Mervis B, Hamdy NAT, Lowik CWGM, Hamersma H, Beighton P, Papapoulos SE. Bone mineral density in sclerosteosis; Affected individuals and gene carriers. Journal of clinical endocrinology & metabolism 2005-Dec-31;90(12):6392-6395. (pubmed)
  258. Bertolino P, Deckers M, Lebrin F, ten Dijke P. Transforming growth factor-beta signal transduction in angiogenesis and vascular disorders. Chest 2005-Dec-31;128(6). (pubmed)
  259. Wicks SJ, Haros K, Maillard M, Song L, Cohen RE, ten Dijke P, Chantry A. The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling. Oncogene 2005-Dec-01;24(54):8080-8084. (pubmed)
  260. Hamdi M, Kool J, Cornelissen-Steijger P, Carlotti F, Popeijus HE, van der Burgt C, Janssen JM, Yasui A, Hoeben RC, Terleth C, Mullenders LH, van Dam H. DNA damage in transcribed genes induces apoptosis via the JNK pathway and the JNK-phosphatase MKP-1. Oncogene 2005-Nov-03;24(48):7135-7144. (pubmed)
  261. van der Horst G, van der Wert SM, Farih-Sips H, van Bezooijen RL, Lowik CWGM, Karperien M. Downregulation of Wnt signaling by increased expression of Dickkopf-1 and-2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells. Journal of bone and mineral research 2005-Oct-31;20(10):1867-1877. (pubmed)
  262. Janssens K, ten Dijke P, Janssens S, Van Hul W. Transforming growth factor-beta 1 to the bone. Endocrine reviews 2005-Oct-31;26(6):743-774. (pubmed)
  263. Tafrechi RSJ, Svensson PJ, Janssen GMC, Szuhai K, Maassen JA, Raap AK. Distinct nuclear gene expression profiles in cells with mtDNA depletion and homoplasmic A3243G mutation. Mutation research-fundamental and molecular mechanisms of mutagenesis 2005-Oct-15;578(1-2):43-52. (pubmed)
  264. Le NH, van der Wal A, van der Bent P, Lantinga-van Leeuwen IS, Breuning MH, van Dam H, de Heer E, Peters DJM. Increased activity of activator protein-1 transcription factor components ATF2, c-Jun, and c-Fos in human and mouse autosomal dominant polycystic kidney disease. Journal of the american society of nephrology 2005-Sep-30;16(9):2724-2731. (pubmed)
  265. Grefhorst A, Hoekstra J, Derks TGJ, Ouwens DM, Baller JFW, Havinga R, Havekes LM, Romijn JA, Kuipers F. Acute hepatic steatosis in mice by blocking beta-oxidation does not reduce insulin sensitivity of very-low-density lipoprotein production. American journal of physiology-gastrointestinal and liver physiology 2005-Sep-30;289(3):G592-G598. (pubmed)
  266. Poole KES, van Bezooijen RL, Loveridge N, Hamersma H, Papapoulos SE, Lowik CW, Reeve J. Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation. Faseb journal 2005-Aug-31;19(10):1842-+. (pubmed)
  267. t Hart LM, Hansen T, Rietveld I, Dekker JM, Nijpels G, Janssen GMC, Arp PA, Uitterlinden AG, Jorgensen T, Borch-Johnsen K, Pols HAP, Pedersen O, van Duijn CM, Heine RJ, Maassen JA. Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene. Diabetes 2005-Jun-30;54(6):1892-1895. (pubmed)
  268. Sayama K, Komatsuzawa H, Yamasaki K, Shirakata Y, Hanakawa Y, Ouhara K, Tokumaru S, Dai XJ, Tohyama M, ten Dijke P, Sugai M, Ichijo H, Hashimoto K. New mechanisms of skin innate immunity: ASK1-mediated keratinocyte differentiation regulates the expression of beta-defensins, LL37, and TLR2. European journal of immunology 2005-Jun-30;35(6):1886-1895. (pubmed)
  269. Jazet IM, Pijl H, Frolich M, Romijn JA, Meinders AE. Two days of a very low calorie diet reduces endogenous glucose production in obese type 2 diabetic patients despite the withdrawal of blood glucose-lowering therapies including insulin. Metabolism-clinical and experimental 2005-Jun-30;54(6):705-712. (pubmed)
  270. Bezooijen RL, ten Dijke P, Papapoulos SE, Lowik CWGM. SOST/sclerostin, an osteocyte-derived negative regulator of bone formation. Cytokine & growth factor reviews 2005-Jun-30;16(3):319-327. (pubmed)
  271. Lebrin F, Deckers M, Bertolino P, ten Dijke P. TGF-beta receptor function in the endothelium. Cardiovascular research 2005-Feb-15;65(3):599-608. (pubmed)
  272. Bazuine M, van den Broek PJA, Maassen JA. Genistein directly inhibits GLUT4-mediated glucose uptake in 3T3-L1 adipocytes. Biochemical and biophysical research communications 2005-Jan-14;326(2):511-514. (pubmed)
  273. Maassen JA, Janssen GMC, 'T Hart LM. Molecular mechanisms of mitochondrial diabetes (MIDD). Annals of medicine 37(3):213-221. (pubmed)
  274. Carvalho RLC, Jonker L, Goumans MJ, Larsson J, Bouwman P, Karisson S, ten Dijke P, Arthur HM, Mummery CL. Defective paracrine signalling by TGF beta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia. Development 2004-Dec-31;131(24):6237-6247. (pubmed)
  275. Papassava P, Gorgoulis VG, Papaevangeliou D, Vlahopoulos S, van Dam H, Zoumpourlis V. Overexpression of activating transcription factor-2 is required for tumor growth and progression in mouse skin tumors. Cancer research 2004-Dec-01;64(23):8573-8584. (pubmed)
  276. Bosch RR, Bazuine M, Span PN, Willems PHGM, Olthaar AJ, Van Rennes H, Maassen JA, Tack CJ, Hermus ARMM, Sweep CGJ. Regulation of GLUT1-mediated glucose uptake by PKC lambda-PKC beta(II) interactions in 3T3-L1 adipocytes. Biochemical journal 2004-Dec-01;384:349-355. (pubmed)
  277. Lopes SMCDS, Feijen A, Korving J, Korchynskyi O, Larsson J, Karlsson S, Ten Dijke P, Lyons KM, Goldschmeding R, Doevendans P, Mummery CL. Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction. Developmental dynamics 2004-Nov-30;231(3):542-550. (pubmed)
  278. Warner AH, Pullumbi E, Amons R, Liu LQ. Characterization of a cathepsin L-associated protein in Artemia and its relationship to the FAS-I family of cell adhesion proteins. European journal of biochemistry 2004-Oct-31;271(20):4014-4025. (pubmed)
  279. Lebrin F, Goumans MJ, Jonker L, Carvalho RLC, Valdimarsdottir G, Thorikay M, Mummery C, Arthur HM, ten Dijke P. Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction. Embo journal 2004-Oct-13;23(20):4018-4028. (pubmed)
  280. Piek E, Van Dinther M, Parks WT, Sallee JM, Bottinger EP, Roberts AB, Ten Dijke P. RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta. Biochemical journal 2004-Oct-01;383:187-199. (pubmed)
  281. de Boer L, van Duyvenvoorde HA, Willemstein-Van Hove EC, Hoogerbrugge CM, Van Doorn J, Maassen JA, Karperien M, Wit JM. Mutations in the NSD1 gene in patients with Sotos syndrome associate with endocrine and paracrine alterations in the IGF system. European journal of endocrinology 2004-Sep-30;151(3):333-341. (pubmed)
  282. Monteiro RM, Lopes SMCD, Korchynskyl O, ten Dijke P, Mummery CL. Spatio-temporal activation of Smad1 and Smad5 in vivo: monitoring transcriptional activity of Smad proteins. Journal of cell science 2004-Sep-15;117(20):4653-4663. (pubmed)
  283. Navarro JA, Lowe CE, Amons R, Kohzuma T, Canters GW, De la Rosa MA, Ubbink M, Hervas M. Functional characterization of the evolutionarily divergent fern plastocyanin. European journal of biochemistry 2004-Aug-31;271(16):3449-3456. (pubmed)
  284. Nijveldt R, Serne EH, Sepers JM, Maassen JA, Cornel JH, Arnold AER. A man with diabetes and heart failure. Lancet 2004-Aug-14;364(9434):636-636. (pubmed)
  285. Bazuine M, Carlotti F, Tafrechi RSJ, Hoeben RC, Maassen JA. Mitogen-activated protein kinase (MAPK) phosphatase-1 and -4 attenuate p38 MAPK during dexamethasone-induced insulin resistance in 3T3-L1 Adipocytes. Molecular endocrinology 2004-Jul-31;18(7):1697-1707. (pubmed)
  286. Bazuine M, van der Zon GCM, van de Ven R, van den Broek PJA, Maassen JA. Rottlerin inhibits multiple steps involved in insulin-induced glucose uptake in 3T3-L1 adipocytes. Biochemical pharmacology 2004-Jul-01;68(1):105-112. (pubmed)
  287. Le NH, van der Bent P, Huls G, van de Wetering M, Loghman-Adham M, Ong ACM, Calvet JP, Clevers H, Breuning MH, van Dam H, Peters DJM. Aberrant polycystin-1 expression results in modification of activator protein-1 activity, whereas Wnt signaling remains unaffected. Journal of biological chemistry 2004-Jun-25;279(26):27472-27481. (pubmed)
  288. ten Dijke P, Hill CS. New insights into TGF-beta-Smad signalling. Trends in biochemical sciences 2004-May-31;29(5):265-273. (pubmed)
  289. Stumvoll M, Fritsche A, t'Hart LM, Machann J, Thamer C, Tschritter O, Van Haeftens TW, Jacob S, Dekker JM, Maassen JA, Machicao F, Schick F, Heine RJ, Haring H. The Gly482Ser variant in the peroxisome proliferator-activated receptor gamma coactivator-1 is not associated with diabetes-related traits in non-diabetic German and Dutch populations. Experimental and clinical endocrinology & diabetes 2004-May-31;112(5):253-257. (pubmed)
  290. Lutz M, Krieglstein K, Schmitt S, ten Dijke P, Sebald W, Wizenmann A, Knaus P. Nerve growth factor mediates activation of the Smad pathway in PC12 cells. European journal of biochemistry 2004-Mar-31;271(5):920-931. (pubmed)
  291. van Bezooijen RL, Roelen BAJ, Visser A, van der Wee-Pals L, de Wilt E, Karperien M, Hamersma H, Papapoulos SE, ten Dijke P, Lowik CWGM. Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist. Journal of experimental medicine 2004-Mar-15;199(6):805-814. (pubmed)
  292. t Hart LM, Fritsche A, Rietveld I, Dekker JM, Nijpels G, Machicao F, Stumvoll M, van Duijn CM, Haring HU, Heine RJ, Maassen JA, van Haeften TW. Genetic factors and insulin secretion - Gene variants in the IGF genes. Diabetes 2004-Feb-28;53:S26-S30. (pubmed)
  293. Maassen JA, 't Hart LM, van Essen E, Heine RJ, Nijpels G, Tafrechi RSJ, Raap AK, Janssen GMC, Lemkes HHPJ. Mitochondrial diabetes - Molecular mechanisms and clinical presentation. Diabetes 2004-Feb-28;53:S103-S109. (pubmed)
  294. De Block CEM, De Leeuw IH, Maassen JA, Ballaux D, Martin JJ. A novel 7301-bp deletion in mitochondrial DNA in a patient with Kearns-Dayre syndrome, diabetes mellitus, and primary amenorrhoea. Experimental and clinical endocrinology & diabetes 2004-Feb-28;112(2):80-83. (pubmed)
  295. Itoh F, Itoh S, Goumans MJ, Valdimarsdottir G, Iso T, Dotto GP, Hamamori Y, Kedes L, Kato M, ten Dijke P. Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. Embo journal 2004-Feb-11;23(3):541-551. (pubmed)
  296. ten Dijke P, Fu JY, Schaap P, Roelen BAJ. Signal transduction of bone morphogenetic proteins in osteoblast differentiation. Journal of bone and joint surgery-american volume 2003-Dec-31;85A:34-38. (pubmed)
  297. Goudriaan JR, Dahlmans VEH, Teusink B, Ouwens DM, Febbraio M, Maassen JA, Romijn JA, Havekes LM, Voshol PJ. CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice. Journal of lipid research 2003-Dec-31;44(12):2270-2277. (pubmed)
  298. ten Dijke P, Korchynskyi E, Valdimarsdottir G, Goumans MJ. Controlling cell fate by bone morphogenetic protein receptors. Molecular and cellular endocrinology 2003-Dec-15;211(1-2):105-113. (pubmed)
  299. Goumans MJ, Valdimarsdottir G, Itoh S, Lebrin F, Larsson J, Mummery C, Karlsson S, ten Dijke P. Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFP/ALK5 signaling. Molecular cell 2003-Oct-31;12(4):817-828. (pubmed)
  300. Bazuine M, Ouwens DM, de Mesquita DSG, Maassen JA. Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity. European journal of biochemistry 2003-Oct-31;270(19):3891-3903. (pubmed)
  301. Maassen JA, Tobias ES, Kayserilli H, Tukel T, Yuksel-Apak M, D'Haens E, Kleijer WJ, Fery F, van der Zon GCM. Identification and functional assessment of novel and known insulin receptor mutations in five patients with syndromes of severe insulin resistance. Journal of clinical endocrinology & metabolism 2003-Sep-30;88(9):4251-4257. (pubmed)
  302. Voshol PJ, Haemmerle G, Ouwens DM, Zimmermann R, Zechner R, Teusink B, Maassen JA, Havekes LM, Romijn JA. Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice. Endocrinology 2003-Aug-31;144(8):3456-3462. (pubmed)
  303. Kurisaki K, Kurisaki A, Valcourt U, Terentiev AA, Pardali K, ten Dijke P, Heldin CH, Ericsson J, Moustakas A. Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation. Molecular and cellular biology 2003-Jul-31;23(13):4494-4510. (pubmed)
  304. Dooley S, Hamzavi J, Breitkopf K, Wiercinska E, Said HM, Lorenzen J, Ten Dijke P, Gressner AM. Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats. Gastroenterology 2003-Jul-31;125(1):178-191. (pubmed)
  305. Bosch RR, Bazuine M, Wake MM, Span PN, Olthaar AJ, Schurmann A, Maassen JA, Hermus RMM, Willems PHGM, Sweep CGJ. Inhibition of protein kinase C beta(II) increases glucose uptake in 3T3-L1 adipocytes through elevated expression of glucose transporter 1 at the plasma membrane. Molecular endocrinology 2003-Jul-31;17(7):1230-1239. (pubmed)
  306. 't Hart LM, Maassen JA, Dekker JM, Heine RJ, Maassen JA. Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus. Diabetologia 2003-Jul-31;46(7):1023-1024. (pubmed)
  307. Kool J, Hamdi M, Cornelissen-Steijger P, van der Eb AJ, Terleth C, van Dam H. Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2. Oncogene 2003-Jul-03;22(27):4235-4242. (pubmed)
  308. van Rheede T, Amons R, Stewart N, de Jong WW. Lactate dehydrogenase A as a highly abundant eye lens protein in platypus (Ornithorhynchus anatinus): Upsilon (upsilon)-crystallin. Molecular biology and evolution 2003-Jun-30;20(6):994-998. (pubmed)
  309. Vanwetswinkel S, Kriek J, Andersen GR, Dijk J, Siegal G. Letter to the editor: H-1, N-15 and C-13 resonance assignments of the highly conserved 19 kDa C-terminal domain from human elongation factor 1B gamma. Journal of biomolecular nmr 2003-Jun-30;26(2):189-190. (pubmed)
  310. Magre J, Delepine M, Van Maldergem L, Robert JJ, Maassen JA, Meier M, Panz VR, Kim CA, Tubiana-Rufi N, Czernichow P, Seemanova E, Buchanan CR, Lacombe D, Vigouroux C, Lascols O, Kahn CR, Capeau J, Lathrop M. Prevalence of mutations in AGPAT2 among human lipodystrophies. Diabetes 2003-Jun-30;52(6):1573-1578. (pubmed)
  311. Van den Ouweland JMW, Cryns K, Pennings RJE, Walraven I, Janssen GMC, Maassen JA, Veldhuijzen BFE, Arntzenius AB, Lindhout D, Cremers CWRJ, Van Camp G, Dikkeschei LD. Molecular characterization of WFS1 in patients with Wolfram syndrome. Journal of molecular diagnostics 2003-May-31;5(2):88-95. (pubmed)
  312. Ikedo H, Tamaki K, Ueda S, Kato S, Fujii M, Ten Dijke P, Okuda S. Smad protein and TGF-beta signaling in vascular smooth muscle cells. International journal of molecular medicine 2003-May-31;11(5):645-650. (pubmed)
  313. Janssens K, ten Dijke P, Ralston SH, Bergmann C, Van Hul W. Transforming growth factor-beta 1 mutations in Camurati-Engelmann disease lead to increased signaling by altering either activation or secretion of the mutant protein. Journal of biological chemistry 2003-Feb-28;278(9):7718-7724. (pubmed)
  314. Edlund S, Bu SH, Schuster N, Aspenstrom P, Heuchel R, Heldin NE, ten Dijke P, Heldin CH, Landstrom M. Transforming growth factor-beta 1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3. Molecular biology of the cell 2003-Feb-28;14(2):529-544. (pubmed)
  315. Itoh S, Thorikay M, Kowanetz M, Moustakas A, Itoh F, Heldin CH, ten Dijke P. Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses. Journal of biological chemistry 2003-Feb-07;278(6):3751-3761. (pubmed)
  316. Chen T, Amons R, Clegg JS, Warner AH, MacRae TH. Molecular characterization of artemin and ferritin from Artemia franciscana. European journal of biochemistry 2003-Jan-31;270(1):137-145. (pubmed)
  317. Maassen JA. Mitochondrial diabetes, diabetes and the thiamine-responsive megaloblastic anaemia syndrome and MODY 2 - Diseases with common pathophysiology?. Panminerva medica 2002-Dec-31;44(4):295-300. (pubmed)
  318. 't Hart LM, van Haeften TW, Dekker JM, Bot M, Heine RJ, Maassen JA. Variations in insulin secretion in carriers of the E23K variant in the KIR6.2 subunit of the ATP-sensitive K+ channel in the beta-cell. Diabetes 2002-Oct-31;51(10):3135-3138. (pubmed)
  319. Ouwens DM, de Ruiter ND, van der Zon GCM, Carter AP, Schouten J, van der Burgt C, Kooistra K, Bos JL, Maassen JA, van Dam H. Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38. Embo journal 2002-Jul-15;21(14):3782-3793. (pubmed)
  320. Dennler S, Goumans MJ, ten Dijke P. Transforming growth factor beta signal transduction. Journal of leukocyte biology 2002-May-31;71(5):731-740. (pubmed)
  321. Itoh F, Divecha N, Brocks L, Oomen L, Janssen H, Calafat J, Itoh S, ten Dijke P. The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-beta/Smad signalling. Genes to cells 2002-Mar-31;7(3):321-331. (pubmed)
  322. 't Hart LM, Nijpels G, Dekker JM, Maassen JA, Heine RJ, van Haeften TW. Variations in insulin secretion in carriers of gene variants in IRS-1 and-2. Diabetes 2002-Mar-31;51(3):884-887. (pubmed)
  323. Schiffer M, Bitzer M, Roberts ISD, Kopp JB, ten Dijke P, Mundel P, Bottinger EP. Apoptosis in podocytes induced by TGF-beta and Smad7. Journal of clinical investigation 2001-Sep-30;108(6):807-816. (pubmed)
  324. Dooley S, Delvoux B, Streckert M, Bonzel L, Stopa M, ten Dijke P, Gressner AM. Transforming growth factor beta signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts - TGF beta signal transduction during transdifferentiation of hepatic stellate cells. Febs letters 2001-Jul-27;502(1-2):4-10. (pubmed)
  325. Inagaki Y, Nemoto T, Nakao A, ten Dijke P, Kobayashi K, Takehara K, Greenwel P. Interaction between GC box binding factors and smad proteins modulates cell lineage-specific alpha 2(I) collagen gene transcription. Journal of biological chemistry 2001-May-11;276(19). (pubmed)
  326. van Dam H, Castellazzi M. Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis. Oncogene 2001-Apr-30;20(19):2453-2464. (pubmed)
  327. Perez S, Vial E, van Dam H, Castellazzi M. Transcription factor ATF3 partially transforms chick embryo fibroblasts by promoting growth factor-independent proliferation. Oncogene 2001-Mar-01;20(9):1135-1141. (pubmed)
  328. van Essen EHR, Roep BO, 't Hart LM, Jansen JJ, Van den Ouweland JMW, Lemkes HHPJ, Maassen JA. HLA-DQ polymorphism and degree of heteroplasmy of the A3243G mitochondrial DNA mutation in maternally inherited diabetes and deafness. Diabetic medicine 2000-Dec-31;17(12):841-847. (pubmed)
  329. Pardali K, Kurisaki A, Moren A, ten Dijke P, Kardassis D, Moustakas A. Role of smad proteins and transcription factor Sp1 in p21(Wafl/Cip1) regulation by transforming growth factor-beta. Journal of biological chemistry 2000-Sep-22;275(38). (pubmed)
  330. Faure S, Lee MA, Keller T, ten Dijke P, Whitman M. Endogenous patterns of TGF beta superfamily signaling during early Xenopus development. Development 2000-Jul-31;127(13):2917-2931. (pubmed)
  331. ten Dijke P, Miyazono K, Heldin CH. Signaling inputs converge on nuclear effecters in TGF-beta signaling. Trends in biochemical sciences 2000-Feb-28;25(2):64-70. (pubmed)
  332. Pardali E, Xie XQ, Tsapogas P, Itoh S, Arvanitidis K, Heldin CH, ten Dijke P, Grundstrom T, Sideras P. Smad and AML proteins synergistically confer transforming growth factor beta 1 responsiveness to human germ-line IgA genes. Journal of biological chemistry 2000-Feb-04;275(5):3552-3560. (pubmed)
  333. Piek E, Moustakas A, Kurisaki A, Heldin CM, ten Dijke P. TGF-beta type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. Journal of cell science 1999-Dec-31;112(24):4557-4568. (pubmed)