All publications

Publications:

  1. van Bekkum DW, Mikkers HMM. Prospects and challenges of induced pluripotent stem cells as a source of hematopoietic stem cells. Hematopoietic stem cells viii 2012-Dec-31;1266:179-188. (pubmed)
  2. de la Garza-Rodea AS, van der Velde-van Dijke I, Boersma H, Goncalves MAFV, van Bekkum DW, de Vries AAF, Knaan-Shanzer S. Myogenic Properties of Human Mesenchymal Stem Cells Derived From Three Different Sources. Cell transplantation 2012-Dec-31;21(1):153-173. (pubmed)
  3. Zaldumbide A, Carlotti F, Goncalves MA, Knaan-Shanzer S, Cramer SJ, Roep BO, Wiertz EJHJ, Hoeben RC. Adenoviral Vectors Stimulate Glucagon Transcription in Human Mesenchymal Stem Cells Expressing Pancreatic Transcription Factors. Plos one 2012-Oct-26;7(10):e48093. (pubmed)
  4. van den Wollenberg DJM, Dautzenberg IJC, van den Hengel SK, Cramer SJ, de Groot RJ, Hoeben RC. Isolation of Reovirus T3D Mutants Capable of Infecting Human Tumor Cells Independent of Junction Adhesion Molecule-A. Plos one 2012-Oct-24;7(10):e48064. (pubmed)
  5. de Vrij J, Dautzenberg IJC, van den Hengel SK, Magnusson MK, Uil TG, Cramer SJ, Vellinga J, Verissimo CS, Lindholm L, Koppers-Lalic D, Hoeben RC. A cathepsin-cleavage site between the adenovirus capsid protein IX and a tumor-targeting ligand improves targeted transduction. Gene therapy 2012-Sep-30;19(9):899-906. (pubmed)
  6. Nittner D, Lambertz I, Clermont F, Mestdagh P, Kohler C, Nielsen SJ, Jochemsen A, Speleman F, Vandesompele J, Dyer MA, Schramm A, Schulte JH, Marine JC. Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation. Nature cell biology 2012-Sep-30;14(9):958. (pubmed)
  7. Mikkers H, Boersma H, Wiekmeijer AS, Pike-Overzet K, van Dongen J, van der Burg M, Staal F. THE GENERATION, REPAIR, AND DIFFERENTIATION OF INDUCED PLURIPOTENT STEM CELLS FROM RAG-SCID PATIENTS. Experimental hematology 2012-Aug-31;40(8). (pubmed)
  8. Gembarska A, Luciani F, Fedele C, Russell EA, Dewaele M, Villar S, Zwolinska A, Haupt S, de Lange J, Yip D, Goydos J, Haigh JJ, Haupt Y, Larue L, Jochemsen A, Shi HB, Moriceau G, Lo RS, Ghanem G, Shackleton M, Bernal F, Marine JC. MDM4 is a key therapeutic target in cutaneous melanoma. Nature medicine 2012-Aug-31;18(8):1239. (pubmed)
  9. Lenos K, Grawenda AM, Lodder K, Kuijjer ML, Teunisse AFAS, Repapi E, Grochola LF, Bartel F, Hogendoorn PCW, Wuerl P, Taubert H, Cleton-Jansen AM, Bond GL, Jochemsen AG. Alternate Splicing of the p53 Inhibitor HDMX Offers a Superior Prognostic Biomarker than p53 Mutation in Human Cancer. Cancer research 2012-Aug-15;72(16):4074-4084. (pubmed)
  10. de Lange J, Verlaan-de Vries M, Teunisse AFAS, Jochemsen AG. Chk2 mediates RITA-induced apoptosis. Cell death and differentiation 2012-Jun-30;19(6):980-989. (pubmed)
  11. de Lange J, Verlaan-de Vries M, Teunisse AFAS, Jochemsen AG. Chk2 mediates RITA-induced apoptosis. Cell death and differentiation 2012-Jun-30;19(6):980-989. (pubmed)
  12. Zhang L, Huang HZ, Zhou FF, Schimmel J, Pardo CG, Zhang TT, Barakat TS, Sheppard KA, Mickanin C, Porter JA, Vertegaal ACO, van Dam H, Gribnau J, Lu CX, ten Dijke P. RNF12 Controls Embryonic Stem Cell Fate and Morphogenesis in Zebrafish Embryos by Targeting Smad7 for Degradation. Molecular cell 2012-Jun-08;46(5):650-661. (pubmed)
  13. Mikkers H, Pike-Overzet K, Staal FJT. Induced pluripotent stem cells and severe combined immunodeficiency: merely disease modeling or potentially a novel cure?. Pediatric research 2012-Apr-30;71(4):427-432. (pubmed)
  14. de Lange J, Ly LV, Lodder K, Verlaan-de Vries M, Teunisse AFAS, Jager MJ, Jochemsen AG. Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanoma. Oncogene 2012-Mar-31;31(9):1105-1116. (pubmed)
  15. van Lummel M, van Veelen PA, Zaldumbide A, de Ru A, Janssen GMC, Moustakas AK, Papadopoulos GK, Drijfhout JW, Roep BO, Koning F. Type 1 Diabetes-associated HLA-DQ8 Transdimer Accommodates a Unique Peptide Repertoire. Journal of biological chemistry 2012-Mar-16;287(12):9514-9524. (pubmed)
  16. Jochemsen AG. Mdmx: A p53 activator?. Cell cycle 2012-Mar-01;11(5):843-843. (pubmed)
  17. Jochemsen AG. Mdmx: A p53 activator?. Cell cycle 2012-Mar-01;11(5):843-843. (pubmed)
  18. Magnusson MK, Kraaij R, Leadley RM, De Ridder CMA, van Weerden WM, Van Schie KAJ, Van der Kroeg M, Hoeben RC, Maitland NJ, Lindholm L. A Transductionally Retargeted Adenoviral Vector for Virotherapy of Her2/neu-Expressing Prostate Cancer. Human gene therapy 2012-Jan-31;23(1):70-82. (pubmed)
  19. Durupt F, Koppers-Lalic D, Balme B, Budel L, Terrier O, Lina B, Thomas L, Hoeben RC, Rosa-Calatrava M. The chicken chorioallantoic membrane tumor assay as model for qualitative testing of oncolytic adenoviruses. Cancer gene therapy 2012-Jan-31;19(1):58-68. (pubmed)
  20. de la Garza-Rodea AS, van der Velde I, Boersma H, Goncalves MAFV, van Bekkum DW, de Vries AAF, Knaan-Shanzer S. Long-Term Contribution of Human Bone Marrow Mesenchymal Stromal Cells to Skeletal Muscle Regeneration in Mice. Cell transplantation 2011-Dec-31;20(2):217-231. (pubmed)
  21. de la Garza-Rodea AS, Verweij MC, Boersma H, van der Velde-van Dijke I, de Vries AA, Hoeben RC, van Bekkum DW, Wiertz EJ, Knaän-Shanzer S. Exploitation of herpesvirus immune evasion strategies to modify the immunogenicity of human mesenchymal stem cell transplants.. Plos one 2011-Dec-31;6(1):e14493. (pubmed)
  22. de la Garza-Rodea AS, Knaan-Shanzer S, van Bekkum DW. Pressure Ulcers: Description of a New Model and Use of Mesenchymal Stem Cells for Repair. Dermatology 2011-Dec-31;223(3):266-284. (pubmed)
  23. Vertegaal ACO. Uncovering Ubiquitin and Ubiquitin-like Signaling Networks. Chemical reviews 2011-Dec-31;111(12):7923-7940. (pubmed)
  24. Lenos K, Jochemsen AG. Functions of MDMX in the Modulation of the p53-Response. Journal of biomedicine and biotechnology 2011-Dec-31;. (pubmed)
  25. Hendriks IA, Schimmel J, Matic I, Mann M, Vertegaal ACO. Proteomic approaches to dissect ubiquitin-like signaling pathways. International journal of molecular medicine 2011-Dec-31;28. (pubmed)
  26. Gonçalves MA, van Nierop GP, Holkers M, de Vries AA. Concerted nicking of donor and chromosomal acceptor DNA promotes homology-directed gene targeting in human cells.. Nucleic acids research 2011-Dec-20;:3443-3455. (pubmed)
  27. Spinnler C, Hedstrom E, Li H, de Lange J, Nikulenkov F, Teunisse AFAS, Verlaan-de Vries M, Grinkevich V, Jochemsen AG, Selivanova G. Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX. Cell death and differentiation 2011-Nov-30;18(11):1736-1745. (pubmed)
  28. Holkers M, de Vries AA, Gonçalves MA. Nonspaced inverted DNA repeats are preferential targets for homology-directed gene repair in mammalian cells.. Nucleic acids research 2011-Nov-12;:1984-1999. (pubmed)
  29. Pike-Overzet K, Rodijk M, Ng YY, Baert MRM, Lagresle-Peyrou C, Schambach A, Zhang F, Hoeben RC, Hacein-Bey-Abina S, Lankester AC, Bredius RGM, Driessen GJA, Thrasher AJ, Baum C, Cavazzana-Calvo M, van Dongen JJM, Staal FJT. Correction of murine Rag1 deficiency by self-inactivating lentiviral vector-mediated gene transfer. Leukemia 2011-Sep-30;25(9):1471-1483. (pubmed)
  30. Eerligh P, van Lummel M, Zaldumbide A, Moustakas AK, Duinkerken G, Bondinas G, Koeleman BPC, Papadopoulos GK, Roep BO. Functional consequences of HLA-DQ8 homozygosity versus heterozygosity for islet autoimmunity in type 1 diabetes. Genes and immunity 2011-Sep-30;12(6):415-427. (pubmed)
  31. Lenos K, de Lange J, Teunisse AFAS, Lodder K, Verlaan-de Vries M, Wiercinska E, van der Burg MJM, Szuhai K, Jochemsen AG. Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts. Molecular cancer 2011-Sep-12;10. (pubmed)
  32. Staal FJT, Baum C, Cowan C, Dzierzak E, Hacein-Bey-Abina S, Karlsson S, Lapidot T, Lemischka I, Mendez-Ferrer S, Mikkers H, Moore K, Moreno E, Mummery CL, Robin C, Suda T, Van Pel M, Brink GV, Zwaginga JJ, Fibbe WE. Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications. Leukemia 2011-Jul-31;25(7):1095-1102. (pubmed)
  33. Naderi EH, Jochemsen AG, Blomhoff HK, Naderi S. Activation of cAMP Signaling Interferes with Stress-Induced p53 Accumulation in ALL-Derived Cells by Promoting the Interaction between p53 and HDM2. Neoplasia 2011-Jul-31;13(7):653. (pubmed)
  34. Koppers-Lalic D, Hoeben RC. Non-human viruses developed as therapeutic agent for use in humans. Reviews in medical virology 2011-Jul-31;21(4):227-239. (pubmed)
  35. Goncalves MAFV, Janssen JM, Nguyen QG, Athanasopoulos T, Hauschka SD, Dickson G, de Vries AAF. Transcription Factor Rational Design Improves Directed Differentiation of Human Mesenchymal Stem Cells Into Skeletal Myocytes. Molecular therapy 2011-Jul-31;19(7):1331-1341. (pubmed)
  36. de Lange J, Ly LV, Lodder K, Verlaan-de Vries M, Teunisse AF, Jager MJ, Jochemsen AG. Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanoma.. Oncogene 2011-Jul-18;. (pubmed)
  37. Koninckx R, Daniels A, Windmolders S, Carlotti F, Mees U, Steels P, Rummens JL, Hendrikx M, Hensen K. Mesenchymal stem cells or cardiac progenitors for cardiac repair? A comparative study. Cellular and molecular life sciences 2011-Jun-30;68(12):2141-2156. (pubmed)
  38. Czepiel M, Balasubramaniyan V, Schaafsma W, Stancic M, Mikkers H, Huisman C, Boddeke E, Copray S. Differentiation of Induced Pluripotent Stem Cells Into Functional Oligodendrocytes. Glia 2011-Jun-30;59(6):882-892. (pubmed)
  39. Ilett EJ, Barcena M, Errington-Mais F, Griffin S, Harrington KJ, Pandha HS, Coffey M, Selby PJ, Limpens RWAL, Mommaas M, Hoeben RC, Vile RG, Melcher AA. Internalization of Oncolytic Reovirus by Human Dendritic Cell Carriers Protects the Virus from Neutralization. Clinical cancer research 2011-May-01;17(9):2767-2776. (pubmed)
  40. van den Hengel SK, de Vrij J, Uil TG, Lamfers ML, Smitt PAES, Hoeben RC. Truncating the i-leader open reading frame enhances release of human adenovirus type 5 in glioma cells. Virology journal 2011-Apr-11;8. (pubmed)
  41. Uil TG, Vellinga J, de Vrij J, van den Hengel SK, Rabelink MJWE, Cramer SJ, Eekels JJM, Ariyurek Y, van Galen M, Hoeben RC. Directed adenovirus evolution using engineered mutator viral polymerases. Nucleic acids research 2011-Mar-31;39(5). (pubmed)
  42. de Vrij J, van den Hengel SK, Uil TG, Koppers-Lalic D, Dautzenberg IJC, Stassen OMJA, Barcena M, Yamamoto M, de Ridder CMA, Kraaij R, Kwappenberg KM, Schilham MW, Hoeben RC. Enhanced transduction of CAR-negative cells by protein IX-gene deleted adenovirus 5 vectors. Virology 2011-Feb-05;410(1):192-200. (pubmed)
  43. de la Garza-Rodea AS, Verweij MC, Boersma H, van der Velde-van Dijke I, de Vries AAF, Hoeben RC, van Bekkum DW, Wiertz EJHJ, Knaan-Shanzer S. Exploitation of Herpesvirus Immune Evasion Strategies to Modify the Immunogenicity of Human Mesenchymal Stem Cell Transplants. Plos one 2011-Jan-06;6(1). (pubmed)
  44. van Leeuwen S, Mikkers H. Long non-coding RNAs: Guardians of development. Differentiation 2010-Dec-31;80(4-5):175-183. (pubmed)
  45. Swildens J, de Vries AAF, Li Z, Umar S, Atsma DE, Schalij MJ, van der Laarse A. Integrin Stimulation Favors Uptake of Macromolecules by Cardiomyocytes In Vitro. Cellular physiology and biochemistry 2010-Dec-31;26(6):999-1010. (pubmed)
  46. Roukens MG, Alloul-Ramdhani M, Baan B, Kobayashi K, Peterson-Maduro J, van Dam H, Schulte-Merker S, Baker DA. Control of endothelial sprouting by a Tel-CtBP complex. Nature cell biology 2010-Oct-31;12(10):933-942. (pubmed)
  47. Phillips A, Teunisse A, Lam S, Lodder K, Darley M, Emaduddin M, Wolf A, Richter J, de Lange J, Verlaan-de Vries M, Lenos K, Bohnke A, Bartel F, Blaydes JP, Jochemsen AG. HDMX-L Is Expressed from a Functional p53-responsive Promoter in the First Intron of the HDMX Gene and Participates in an Autoregulatory Feedback Loop to Control p53 Activity. Journal of biological chemistry 2010-Sep-17;285(38). (pubmed)
  48. Roukens MG, Alloul-Ramdhani M, Baan B, Kobayashi K, Peterson-Maduro J, van Dam H, Schulte-Merker S, Baker DA. Control of endothelial sprouting by a Tel-CtBP complex.. Nature cell biology 2010-Sep-12;. (pubmed)
  49. Louz D, Bergmans HE, Loos BP, Hoeben RC. Emergence of viral diseases: mathematical modeling as a tool for infection control, policy and decision making. Critical reviews in microbiology 2010-Aug-31;36(3):195-211. (pubmed)
  50. Matic I, Schimmel J, Hendriks IA, van Santen MA, van de Rijke F, van Dam H, Gnad F, Mann M, Vertegaal ACO. Site-Specific Identification of SUMO-2 Targets in Cells Reveals an Inverted SUMOylation Motif and a Hydrophobic Cluster SUMOylation Motif. Molecular cell 2010-Aug-27;39(4):641-652. (pubmed)
  51. Kleijwegt FS, Laban S, Duinkerken G, Joosten AM, Zaldumbide A, Nikolic T, Roep BO. Critical Role for TNF in the Induction of Human Antigen-Specific Regulatory T Cells by Tolerogenic Dendritic Cells. Journal of immunology 2010-Aug-01;185(3):1412-1418. (pubmed)
  52. de Vrij J, Willemsen RA, Lindholm L, Hoeben RC. Adenovirus-Derived Vectors for Prostate Cancer Gene Therapy. Human gene therapy 2010-Jul-31;21(7):795-805. (pubmed)
  53. de Vrij J, Willemsen RA, Lindholm L, Hoeben RC, , Bangma CH, Barber C, Behr JP, Briggs S, Carlisle R, Cheng WS, Dautzenberg IJ, de Ridder C, Dzojic H, Erbacher P, Essand M, Fisher K, Frazier A, Georgopoulos LJ, Jennings I, Kochanek S, Koppers-Lalic D, Kraaij R, Kreppel F, Magnusson M, Maitland N, Neuberg P, Nugent R, Ogris M, Remy JS, Scaife M, Schenk-Braat E, Schooten E, Seymour L, Slade M, Szyjanowicz P, Totterman T, Uil TG, Ulbrich K, van der Weel L, van Weerden W, Wagner E, Zuber G. Adenovirus-derived vectors for prostate cancer gene therapy.. Human gene therapy 2010-Jul-31;21(7). (pubmed)
  54. Van der Laarse A, Swildens J, Li ZY, De Vries A, Umar S, Atsma D, Schalij M, Van der Wall E. NO-Dependency of Integrin Stimulation-induced Hypertrophy in Rat Cardiomyocytes. Circulation 2010-Jul-13;122(2). (pubmed)
  55. Zaldumbide A, Weening S, Cramer SJ, Rabelink MJWE, Verhaagen J, Hoeben RC. A potentially immunologically inert derivative of the reverse tetracycline-controlled transactivator. Biotechnology letters 2010-Jun-30;32(6):749-754. (pubmed)
  56. Carlotti F, Zaldumbide A, Loomans CJ, van Rossenberg E, Engelse M, de Koning EJ, Hoeben RC. Isolated human islets contain a distinct population of mesenchymal stem cells. Islets 2010-Jun-30;2(3):164-173. (pubmed)
  57. Schimmel J, Balog CIA, Deelder AM, Drijfhout JW, Hensbergen PJ, Vertegaal ACO. Positively charged amino acids flanking a sumoylation consensus tetramer on the 110 kDa tri-snRNP component SART1 enhance sumoylation efficiency. Journal of proteomics 2010-Jun-16;73(8):1523-1534. (pubmed)
  58. Goncalves MAFV, Janssen JM, Holkers M, de Vries AAF. Rapid and Sensitive Lentivirus Vector-Based Conditional Gene Expression Assay to Monitor and Quantify Cell Fusion Activity. Plos one 2010-Jun-03;5(6). (pubmed)
  59. Hollestelle A, Nagel JHA, Smid M, Lam S, Elstrodt F, Wasielewski M, Ng SS, French PJ, Peeters JK, Rozendaal MJ, Riaz M, Koopman DG, ten Hagen TLM, de Leeuw BHCGM, Zwarthoff EC, Teunisse A, van der Spek PJ, Klijn JGM, Dinjens WNM, Ethier SP, Clevers H, Jochemsen AG, den Bakker MA, Foekens JA, Martens JWM, Schutte M. Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines. Breast cancer research and treatment 2010-May-31;121(1):53-64. (pubmed)
  60. van Hagen M, Overmeer RM, Abolvardi SS, Vertegaal ACO. RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2 alpha. Nucleic acids research 2010-Apr-30;38(6):1922-1931. (pubmed)
  61. Vertegaal ACO. SUMO chains: polymeric signals. Biochemical society transactions 2010-Feb-28;38:46-49. (pubmed)
  62. Jochemsen AG, Shiloh Y. USP10: Friend and Foe. Cell 2010-Feb-05;140(3):308-310. (pubmed)
  63. de la Garza-Rodea AS, Knaän-Shanzer S, den Hartigh JD, Verhaegen AP, van Bekkum DW. Anomer-equilibrated streptozotocin solution for the induction of experimental diabetes in mice (Mus musculus).. Journal of the american association for laboratory animal science : jaalas 2010-Jan-31;49(1). (pubmed)
  64. de la Garza-Rodea AS, Knaaen-Shanzer S, den Hartigh JD, Verhaegen APL, van Bekkum DW. Anomer-Equilibrated Streptozotocin Solution for the Induction of Experimental Diabetes in Mice (Mus musculus). Journal of the american association for laboratory animal science 2010-Jan-31;49(1):40-44. (pubmed)
  65. Van Den Wollenberg DJM, Van Den Hengel SK, Dautzenberg IJC, Kranenburg O, Hoeben RC. Modification of mammalian reoviruses for use as oncolytic agents. Expert opinion on biological therapy 2009-Dec-31;9(12):1509-1520. (pubmed)
  66. Uren AG, Mikkers H, Kool J, van der Weyden L, Lund AH, Wilson CH, Rance R, Jonkers J, van Lohuizen M, Berns A. A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites. Nature protocols 2009-Dec-31;4(5):789-798. (pubmed)
  67. Duinsbergen D, Salvatori D, Eriksson M, Mikkers H. Tumors Originating from Induced Pluripotent Stem Cells and Methods for Their Prevention. Hematopoietic stem cells vii 2009-Dec-31;1176:197-204. (pubmed)
  68. Boesten LSM, Zadelaar ASM, van Nieuwkoop A, Hu LH, Teunisse AFAS, Jochemsen AG, Evers B, van de Water B, Gijbels MJJ, van Vlijmen BJM. Macrophage p53 controls macrophage death in atherosclerotic lesions of apolipoprotein E deficient mice. Atherosclerosis 2009-Dec-31;207(2):399-404. (pubmed)
  69. van Hagen M, Overmeer RM, Abolvardi SS, Vertegaal AC. RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2{alpha}. Nucleic acids research 2009-Dec-21;. (pubmed)
  70. Wang XL, Herr RA, Rabelink M, Hoeben RC, Wiertz EJHJ, Hansen TH. Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates. Journal of cell biology 2009-Nov-30;187(5):655-668. (pubmed)
  71. Uil TG, de Vrij J, Vellinga J, Rabelink MJWE, Cramer SJ, Chan OYA, Pugnali M, Magnusson M, Lindholm L, Boulanger P. A lentiviral vector-based adenovirus fiber-pseudotyping approach for expedited functional assessment of candidate retargeted fibers. Journal of gene medicine 2009-Nov-30;11(11):990-1004. (pubmed)
  72. Brouwer AK, Schimmel J, Wiegant JCAG, Vertegaal ACO, Tanke HJ, Dirks RW. Telomeric DNA Mediates De Novo PML Body Formation. Molecular biology of the cell 2009-Nov-15;20(22):4804-4815. (pubmed)
  73. Zhang XN, Lin L, Guo HR, Yang JH, Jones SN, Jochemsen A, Lu XB. Phosphorylation and Degradation of MdmX Is Inhibited by Wip1 Phosphatase in the DNA Damage Response. Cancer research 2009-Oct-15;69(20):7960-7968. (pubmed)
  74. van Nierop GP, de Vries AAF, Holkers M, Vrijsen KR, Goncalves MAFV. Stimulation of homology-directed gene targeting at an endogenous human locus by a nicking endonuclease. Nucleic acids research 2009-Sep-30;37(17):5725-5736. (pubmed)
  75. Schrage YM, Lam S, Jochemsen AG, Cleton-Jansen AM, Taminiau AHM, Hogendoorn PCW, Bovee JVMG. Central chondrosarcoma progression is associated with pRb pathway alterations: CDK4 down-regulation and p16 overexpression inhibit cell growth in vitro. Journal of cellular and molecular medicine 2009-Sep-30;13(9A):2843-2852. (pubmed)
  76. Richter J, Wolf A, Lam S, Bohnke A, Teunisse A, Lodder K, Hauptmann S, Jochemsen AG, Bartell F. Activation of p53 stimulates transcription from the MDMX P2 promoter in tumor cells. Ejc supplements 2009-Sep-30;7(2):103-103. (pubmed)
  77. Chadt A, Carlotti F, Hoeben RC, Joost HG, Al-Hasani H. TBC1D1-dependent regulation of glucose and lipid metabolism in cultured C2C12 myotubes. Diabetologia 2009-Sep-30;52. (pubmed)
  78. Bernhardt U, Carlotti F, Hoeben RC, Joost HG, Al-Hasani H. A dual role of the N-terminal FQQI motif in GLUT4 trafficking. Biological chemistry 2009-Sep-30;390(9):883-892. (pubmed)
  79. Ohtsubo C, Shiokawa D, Kodama M, Gaiddon C, Nakagama H, Jochemsen AG, Taya Y, Okamoto K. Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2. Cancer science 2009-Jul-31;100(7):1291-1299. (pubmed)
  80. Wang YYV, Leblanc M, Wade M, Jochemsen AG, Wahl GM. Increased Radioresistance and Accelerated B Cell Lymphomas in Mice with Mdmx Mutations that Prevent Modifications by DNA-Damage-Activated Kinases. Cancer cell 2009-Jul-07;16(1):33-43. (pubmed)
  81. Kuiperij HB, van Pel M, de Rooij KE, Hoeben RC, Fibbe WE. Serpinal (alpha 1-AT) is synthesized in the osteoblastic stem cell niche. Experimental hematology 2009-May-31;37(5):641-647. (pubmed)
  82. Zuckerman V, Lenos K, Popowicz GM, Silberman I, Grossman T, Marine JC, Holak TA, Jochemsen AG, Haupt Y. c-Abl Phosphorylates Hdmx and Regulates Its Interaction with p53. Journal of biological chemistry 2009-Feb-06;284(6):4031-4039. (pubmed)
  83. IDENTIFICATION OF CELLULAR DYNAMIC PATTERNS RESULTING FROM REPETITIVE PHOTOBLEACHING USING INDEPENDENT COMPONENT ANALYSIS. :1382-1385. (pubmed)
  84. van den Wollenberg DJM, van den Hengel SK, Dautzenberg IJC, Cramer SJ, Kranenburg O, Hoeben RC. A strategy for genetic modification of the spike-encoding segment of human reovirus T3D for reovirus targeting. Gene therapy 2008-Dec-31;15(24):1567-1578. (pubmed)
  85. Knaan-Shanzer S, van der Velde-van Dijke I, van de Watering MJM, de Leeuw PJ, Valerio D, van Bekkum DW, de Vriesa AAF. Phenotypic and Functional Reversal Within the Early Human Hematopoietic Compartment. Stem cells 2008-Dec-31;26(12):3210-3217. (pubmed)
  86. Raz V, Vermolen BJ, Garini Y, Onderwater JJM, Mommaas-Kienhuis MA, Koster AJ, Young IT, Tanke H, Dirks RW. The nuclear lamina promotes telomere aggregation and centromere peripheral localization during senescence of human mesenchymal stem cells. Journal of cell science 2008-Dec-15;121(24):4018-4028. (pubmed)
  87. Schimmel J, Larsen KM, Matic I, van Hagen M, Cox J, Mann M, Andersen JS, Vertegaal ACO. The Ubiquitin-Proteasome System Is a Key Component of the SUMO-2/3 Cycle. Molecular & cellular proteomics 2008-Nov-30;7(11):2107-2122. (pubmed)
  88. Chadt A, Leicht K, Deshmukh A, Jiang LQ, Scherneck S, Bernhardt U, Dreja T, Vogel H, Schmolz K, Kluge R, Zierath JR, Hultschig C, Hoeben RC, Schurmann A, Joost HG, Al-Hasani H. Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity. Nature genetics 2008-Nov-30;40(11):1354-1359. (pubmed)
  89. Van Tuyn J, Pijnappels DA, Haeck ML, Knaan-Shanzer S, Scherjon S, Goumans MJ, de Vries AA, van der Laarse A, Schalij MJ, Atsma DE. Potential of Human Mesenchymal Stem Cells to Differentiate Into Cardiomyocytes Depends on Donor Age and Donor Tissue. Circulation 2008-Oct-28;118(18). (pubmed)
  90. Duinsbegen D, Eriksson M, 't Hoen PAC, Frisen J, Mikkers H. Induced pluripotency with endogenous and inducible genes. Experimental cell research 2008-Oct-15;314(17):3255-3263. (pubmed)
  91. Vermolen BJ, Garini Y, Young IT, Dirks RW, Raz V. Segmentation and analysis of the three-dimensional redistribution of nuclear components in human mesenchymal stem cells. Cytometry part a 2008-Sep-30;73A(9):816-824. (pubmed)
  92. Eggers R, Hendriks WTJ, Tannemaat MR, van Heerikhuize JJ, Pool CW, Carlstedt TP, Zaldumbide A, Hoeben RC, Boer GJ, Verhaagen J. Neuroregenerative effects of lentiviral vector-mediated GDNF expression in reimplanted ventral roots. Molecular and cellular neuroscience 2008-Sep-30;39(1):105-117. (pubmed)
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  201. Molenaar C, Abdulle A, Gena A, Tanke HJ, Dirks RW. Poly(A)(+) RNAs roam the cell nucleus and pass through speckle domains in transcriptionally active and inactive cells. Journal of cell biology 2004-Apr-26;165(2):191-202. (pubmed)
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  204. Verwijnen SM, Smith PAES, Hoeben RC, Rabelink MJWE, Wiebe L, Curiel DT, Hemminki A, Krenning EP, de Jong M. Molecular imaging and treatment of malignant gliomas following adenoviral transfer of the herpes simplex virus-thymidine kinase gene and the somatostatin receptor subtype 2 gene. Cancer biotherapy and radiopharmaceuticals 2004-Feb-28;19(1):111-120. (pubmed)
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  207. Chalkley GE, Verrijzer CP. Immuno-depletion and purification strategies to study chromatin-remodeling factors in vitro. Chromatin and chromatin remodeling enzymes, pt c 377:421-442. (pubmed)
  208. van der Eb MM, Geutskens SB, van Kuilenburg ABP, van Lenthe H, van Dierendonck JH, Kuppen PJK, van Ormondt H, van de Velde CJH, Wanders RJA, van Gennip AH, Hoeben RC. Ganciclovir nucteotides accumulate in mitochondria of rat liver cells expressing the herpes simplex virus thymidine kinase gene. Journal of gene medicine 2003-Dec-31;5(12):1018-1027. (pubmed)
  209. Abou El Hassan MAI, Rabelink MJWE, van der Vijgh WJF, Bast A, Hoeben RC. A comparative study between catalase gene therapy and the cardioprotector monohydroxyethylrutoside (MonoHER) in protecting against doxorubicin-induced cardiotoxicity in vitro. British journal of cancer 2003-Dec-01;89(11):2140-2146. (pubmed)
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  213. Kanerva A, Zinn KR, Chaudhuri TR, Lam JT, Suzuki K, Uil TG, Hakkarainen T, Bauerschmitz GJ, Wang MH, Liu B, Cao ZH, Alvarez RD, Curiel DT, Hemminki A. Enhanced therapeutic efficacy for ovarian cancer with a serotype 3 receptor-targeted oncolytic adenovirus. Molecular therapy 2003-Sep-30;8(3):449-458. (pubmed)
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  215. Lard LR, van Gaalen FA, Schonkeren JJM, Pieterman EJ, Stoeken G, Vos K, Nelissen RGHH, Westendorp RGJ, Hoeben RC, Breedveld FC, Toes REM, Huizinga TWJ. Association of the-2849 interleukin-10 promoter polymorphism with autoantibody production and joint destruction in rheumatoid arthritis. Arthritis and rheumatism 2003-Jul-31;48(7):1841-1848. (pubmed)
  216. Mahmoudi T, Zuijderduijn LMP, Mohd-Sarip A, Verrijzer CP. GAGA facilitates binding of Pleiohomeotic to a chromatinized Polycomb response element. Nucleic acids research 2003-Jul-15;31(14):4147-4156. (pubmed)
  217. El Hassan MAIA, Heijn M, Rabelink MJWE, van der Vijgh WJF, Bast A, Hoeben RC. The protective effect of cardiac gene transfer of CuZn-sod in comparison with the cardioprotector monohydroxyethylrutoside against doxorubicin-induced cardiotoxicity in cultured cells. Cancer gene therapy 2003-Apr-30;10(4):270-277. (pubmed)
  218. Martens JHA, Verlaan M, Kalkhoven E, Zantema A. Cascade of distinct histone modifications during collagenase gene activation. Molecular and cellular biology 2003-Mar-31;23(5):1808-1816. (pubmed)
  219. Vertegaal ACO, Kuiperij HB, Houweling A, Verlaan M, van der Eb AJ, Zantema A. Differential expression of tapasin and immunoproteasome subunits in adenovirus type 5-versus type 12-transformed cells. Journal of biological chemistry 2003-Jan-03;278(1):139-146. (pubmed)
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