Non-alcoholic liver failure (NAFLD) is the most common cause of abnormal liver blood tests and has an increasing prevalence in the community. Complications of this disease and ultimately the need for liver transplantation are increasingly seen. Our research is aimed at noninvasive identification of and improving treatment of patients with NAFLD at high risk of complications. Current projects include 1) studies within the NEO study (Dutch Epidemiology of Obesity Study) in collaboration with the Departments of Epidemiology and Radiology LUMC and 2) RADIcAL study, aimed at cost-effectiveness and accuracy of noninvasive diagnostics of NAFLD/NASH in patients suspected of NAFLD and patients after liver transplantation, funded by a Horizon2020 grant and executed in a European consortium. Moreover, we participate in several phase II and III pharmaceutical studies, in collaboration with the Centre for Human Drug Research, the Dutch Donor Feces Bank and the Department of Microbiology of the LUMC.