Marieke Barnhoorn



Mesenchymal stem cells as a treatment for inflammatory bowel diseases

In this research project we study the use of mesenchymal stem cells for the treatment of Crohn’s Disease and Ulcerative Colitis. We explore the potential of stem cells to treat luminal disease and the complications of inflammatory bowel diseases, like perianal fistulas. Both cell models (like organoids, so called mini-guts) and animal models are used to investigate the effect of stem cells both in vitro and in vivo. Furthermore, also clinical trials are performed in this research project to explore the safety and effectiveness of stem cell therapy in patients with inflammatory bowel diseases.


Marieke Barnhoorn graduated Medicine at Leiden University and started her PhD in the lab of Prof. Hein Verspaget and Dr. Luuk Hawinkels in 2015. Together with Dr. Andrea van der Meulen- de Jong she started the MSC-P(roctitis) clinical trial. 




Leids Universitair Medisch Centrum
Gebouw 1

Albinusdreef 2
2333 ZA Leiden

Postbus 9600
2300 RC Leiden