Expertise

Pharmacology

Leiden University Medical Center - Clinical Pharmacy & Toxicology

It is our goal to optimize treatment of the patient by personalising the dose and drug selection based on a better understanding of the genetic variation that is causal for the inter-patient variability in drug response. We also aim to develop algorithms that include genetic and non-genetic markers that can be readily translated to daily clinical practice. To achieve these research ambitions we have formed a group of experts that covers the required fields within the field of clinical pharmacology, pharmacogenomics, pharmacokinetics, pharmacodynamics, pharmacometrics and bio-analytics. A well-equipped GMP-facility and Bioanalytical Laboratory belongs to our research infrastructure.

Experts

Prof. dr. Henk-Jan Guchelaar
Dr. Jesse Swen
Dr. Yahya Anvar
Dr. Dirk-Jan Moes
Dr. Anton Terwisscha van Scheltinga
Dr. Maarten Deenen

Research lines


Clinical pharmacogenomics
Preclinical germline pharmacogenomics
Computational modelling of tumor growth and clone development of heterogeneous tumors