The department of Molecular Cell Biology of the LUMC aims to understand the molecular mechanisms that underlie the function and activity of cells and tissues, unravel the molecular defects that form the basis of inherited and acquired disease, and make this knowledge and related technology emanating from this research available to others for improved diagnosis or to develop novel treatment modalities. One of the diseases that we investigate is type 2 diabetes.
Dr. Leen M. ‘t Hart
Dr. Roderick Slieker
Type 2 diabetes
In a joint effort of the LUMC depts. of Molecular Cell Biology and Molecular Epidemiology and the depts. of Epidemiology and Biostatics and Primary Care of the VUmc Amsterdam we aim to identify molecular and clinical factors associated with progression of type 2 diabetes to improve treatment of the individual patient. For this we use various large scale cohort studies such as the Hoorn studies and the Hoorn Diabetes Care System cohort (DCS, n=12000). In the latter study we use annually collect data from routine care in combination with modern molecular profiling (genomics, transcriptomics and metabolomics) to identify factors associated with response to treatment and disease progression. Internationally we collaborate in various large projects relating to personalized therapeutics and type 2 diabetes (www.imi-rhapsody.eu; www.DIRECT-diabetes.org; www.pgrn.org/metgen.html).
Dr Leen M. ‘t Hart