Expertise

Genetics/Genomics

Leiden University Medical Center – Human Genetics and Leiden Genome Technology Center

We investigate the mechanistic basis of disease to enable the translation of rationalized and personalized genomics into personalized healthcare. Research in the department employs yeast, mouse and human cell models, and advanced -omics, genetics, bioinformatics and biosemantics, cell biology and biochemical technology approaches for the unravelling of disease mechanisms. Moreover we use disease- and population-based cohorts for the discovery of genetic and other molecular biomarkers for patient diagnosis and stratification. Based on the obtained insights we are developing technologies for the personalized prediction of predisposition to and progression of disease, and responses to preventive and curative interventions. As an example, we have a long track record in the development of mutation-specific treatments using antisense technologies.  

Experts

Prof.dr. Silvère M. van der Maarel
Prof. Dr. Annemieke Aartsma-Rus
Dr. Willeke M.C. van Roon
Prof. dr. Dorien J.M. Peters
Dr. Stefan J. White


Developing therapies for Duchenne Muscular Dystrophy
Developing therapies for Polyglutamine disorders
Developing therapies for Polycystic Kidney Disease
Leiden Genome Technology Center (LGTC)