Belangrijke publicaties

Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism. Stott DJ, Rodondi N, Kearney PM, Ford I, Westendorp RG, Mooijaart SP, Sattar N, Aubert CE, Aujesky D, Bauer DC, Baumgartner C, Blum MR, Browne JP, Byrne S, Collet TH, Dekkers OM, den Elzen WP, Du Puy RS, Ellis G, Feller M, Floriani C, Hendry K, Hurley C, Jukema JW, Kean S, Kelly M, Krebs D, Langhorne P, McCarthy G, McCarthy V, McConnachie A, McDade M, Messow M, O'Flynn A, O'Riordan D, Poortvliet RK, Quinn TJ, Russell A, Sinnott C, Smit JW, Van Dorland HA, Walsh KA, Walsh EK, Watt T, Wilson R, Gussekloo J; TRUST Study Group. N Engl J Med. 2017 Jun 29;376(26):2534-2544. 

Effect of intranasally administered insulin on cerebral blood flow and perfusion; a randomized experiment in young and older adults. Akintola AA, van Opstal AM, Westendorp RG, Postmus I, van der Grond J,  van Heemst D. Aging (Albany NY). 2017 Mar 14;9(3):790-802.

Assessment of causality between serum gamma-glutamyltransferase and type 2 diabetes mellitus using publicly available data: a Mendelian randomization study. Noordam R, Smit RA, Postmus I, Trompet S,  van Heemst D. Int J Epidemiol. 2016 Dec 1;45(6):1953-1960

Predicting adverse health outcomes in older emergency department patients: the APOP study. de Gelder J, Lucke JA, de Groot B, Fogteloo AJ, Anten S, Mesri K, Steyerberg EW, Heringhaus C, Blauw GJ, Mooijaart SP. Neth J Med. 2016 Oct;74(8):342-352.

Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity. van der Spoel E, Jansen SW, Akintola AA, Ballieux BE, Cobbaert CM, Slagboom PE, Blauw GJ, Westendorp RG, Pijl H, Roelfsema F,  van Heemst D. Aging Cell. 2016 Sep 7. doi: 10.1111/acel.12519. [Epub ahead of print]

Functional and Cognitive Impairment, Frailty, and Adverse Health Outcomes in Older Patients Reaching ESRD-A Systematic Review. Kallenberg MH, Kleinveld HA, Dekker FW, van Munster BC, Rabelink TJ, van Buren M, Mooijaart SP.Clin J Am Soc Nephrol. 2016 Sep 7;11(9):1624-39

Higher Visit-to-Visit Low-Density Lipoprotein Cholesterol Variability Is Associated With Lower Cognitive Performance, Lower Cerebral Blood Flow, and Greater White Matter Hyperintensity Load in Older Subjects. Smit RA, Trompet S, Sabayan B, le Cessie S, van der Grond J, van Buchem MA, de Craen AJ, Jukema JW. Circulation.  2016  Jul 19;134(3):212-21.

Evidence-based medicine in older patients: how can we do better? Mooijaart SP, Broekhuizen K, Trompet S, de Craen AJ, Gussekloo J, Oleksik A, van Heemst D, Blauw GJ, Muller M. Neth J Med. 2015 Jun;73(5):211-8.

Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism. Jansen SW, Akintola AA, Roelfsema F, van der Spoel E, Cobbaert CM, Ballieux BE, Egri P, Kvarta-Papp Z, Gereben B, Fekete C, Slagboom PE, van der Grond J, Demeneix BA, Pijl H, Westendorp RG, van Heemst D. Sci Rep. 2015 Jun 19;5:11525.

Characteristics of randomized controlled trials designed for elderly: a systematic review. Broekhuizen K, Pothof A, de Craen AJ, Mooijaart SP. PLoS One. 2015 May 15;10(5):e0126709.

Pharmacogenetic  meta-analysis   of  genome-wide association studies  of  LDL cholesterol response  to  statins.Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K, Arsenault BJ, Donnelly LA, Wiggins KL, Avery CL, Griffin P, Feng Q, Taylor KD, Li G, Evans DS, Smith AV, de Keyser CE, Johnson AD, de Craen AJ, Stott DJ, Buckley BM, Ford I, Westendorp RG, Slagboom PE, Sattar N, Munroe PB, Sever P, Poulter N, Stanton A, Shields DC, O'Brien E, Shaw-Hawkins S, Chen YD, Nickerson DA, Smith JD, Dubé MP, Boekholdt SM, Hovingh GK, Kastelein JJ, McKeigue PM, Betteridge J, Neil A, Durrington PN, Doney A, Carr F, Morris A, McCarthy MI, Groop L, Ahlqvist E; Welcome Trust Case Control Consortium., Bis JC, Rice K, Smith NL, Lumley T, Whitsel EA, Stürmer T, Boerwinkle E, Ngwa JS, O'Donnell CJ, Vasan RS, Wei WQ, Wilke RA, Liu CT, Sun F, Guo X, Heckbert SR, Post W, Sotoodehnia N, Arnold AM, Stafford JM, Ding J, Herrington DM, Kritchevsky SB, Eiriksdottir G, Launer LJ, Harris TB, Chu AY, Giulianini F, MacFadyen JG, Barratt BJ, Nyberg F, Stricker BH, Uitterlinden AG, Hofman A, Rivadeneira F, Emilsson V, Franco OH, Ridker PM, Gudnason V, Liu Y, Denny JC, Ballantyne CM, Rotter JI, Adrienne Cupples L, Psaty BM, Palmer CN, Tardif JC, Colhoun HM, Hitman G, Krauss RM, Wouter Jukema J, Caulfield MJ. Nat Commun. 2014 Oct 28;5:5068.

Thyroid hormone signaling and homeostasis during aging. Bowers J, Terrien J, Clerget-Froidevaux MS, Gothié JD, Rozing MP, Westendorp RG,  van Heemst  D, Demeneix  BA. Endocr Rev. 2013 Aug;34(4):556-89.

Association of visit-to-visit variability in blood pressure with cognitive function in old age: prospective cohort study. Sabayan B, Wijsman LW, Foster-Dingley JC, Stott DJ, Ford I, Buckley BM, Sattar N, Jukema JW, van Osch MJ, van der Grond J, van Buchem MA, Westendorp RG, de Craen AJ, Mooijaart SP. BMJ. 2013 Jul 29;347:f4600.

Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study. Westendorp  RG, van Heemst D,  Rozing  MP, Frölich M, Mooijaart SP, Blauw GJ, Beekman M, Heijmans BT, de Craen AJ, Slagboom PE; Leiden Longevity Study Group. J Am Geriatr Soc. 2009 Sep;57(9):1634-7.

Thyroid status, disability and cognitive function, and survival in old age. Gussekloo J, van Exel E, de Craen AJ, Meinders AE, Frölich M, Westendorp RG. JAMA. 2004 Dec 1;292(21):2591-9.

Pravastatin   in  elderly  individuals  at  risk of  vascular disease  (PROSPER): a  randomised controlled trial. Shepherd J, Blauw GJ, Murphy MB, Bollen EL, Buckley BM, Cobbe SM, Ford I, Gaw A, Hyland M, Jukema JW, Kamper AM, Macfarlane PW, Meinders AE, Norrie J, Packard CJ, Perry IJ, Stott DJ, Sweeney BJ, Twomey C, Westendorp RG;  PROSPER  study group. PROspective Study of  Pravastatin  in the  Elderly  at  Risk. Lancet. 2002 Nov 23;360(9346):1623-30.