Tuberculosis research (tbc)

Systems biology approaches in bacterial infections to define new antibiotics

Together with other researchers at LUMC we discovered a new host kinase pathway involved in controlling infection with several major bacteria (Mycobacterium tuberculosis, Salmonella, the cause of typhoid fever). We are using "systems biology" approaches to decipher the networks in immune cells involved in controlling these pathogens.

This work involves high throughput screening of siRNA libraries (to knock out single human genes) and chemical compound libraries to discover new drugs, drug targets, regulatory signaling networks involved and mode of action of host-directed compounds which also work against antibiotic resistant bacteria. Several new leads are under scrutiny.