Publications

1. Li Z, Yi CX, Katiraei S, Kooijman S, Zhou E, Chung CK, Gao Y, van den Heuvel JK, Meijer OC, Berbée JFP, Heijink M, Giera M, Willems van Dijk K, Groen AK, Rensen PCN, Wang Y. Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit. Gut. (2017) Nov 3. pii: gutjnl-2017-314050. doi: 10.1136/gutjnl-2017-314050. [Epub ahead of print] (IF=16.66)

2. Liu J, van Klinken JB, Semiz S, Willems van Dijk K, Verhoeven A, Hankemeier T, Harms AC, Sijbrands E, Sheehan NA, van Duijn CM, Demirkan A. A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes. Diabetes. (2017) 66:2915-2926. (IF=8.68)

3. Kettunen J, Demirkan A, Würtz P, Draisma HH, Haller T, Rawal R, Vaarhorst A, Kangas AJ, Lyytikäinen LP, Pirinen M, Pool R, Sarin AP, Soininen P, Tukiainen T, Wang Q, Tiainen M, Tynkkynen T, Amin N, Zeller T, Beekman M, Deelen J, Willems van Dijk K, Esko T, Hottenga JJ, van Leeuwen EM, Lehtimäki T, Mihailov E, Rose RJ, de Craen AJ, Gieger C, Kähönen M, Perola M, Blankenberg S, Savolainen MJ, Verhoeven A, Viikari J, Willemsen G, Boomsma DI, van Duijn CM, Eriksson J, Jula A, Järvelin MR, Kaprio J, Metspalu A, Raitakari O, Salomaa V, Slagboom PE, Waldenberger M, Ripatti S, Ala-Korpela M. Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. Nat Commun. (2016) Mar 23;7:11122. (IF=11.47)

4. Kilpeläinen TO, … Henneman P, Willems van Dijk K, … Loos RJ. Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Nat Commun. (2016) Feb 1;7:10494. (IF=11.47)

5. van Klinken JB, Willems van Dijk K. FluxModeCalculator: an efficient tool for large-scale flux mode computation. Bioinformatics. (2016) 32:1265-6 (IF=7.31)

6. Wang Y, van der Tuin S, Tjeerdema N, van Dam AD, Rensen SS, Hendrikx T, Berbée JF, Atanasovska B, Fu J, Hoekstra M, Bekkering S, Riksen NP, Buurman WA, Greve JW, Hofker MH, Shiri-Sverdlov R, Meijer OC, Smit JW, Havekes LM, Willems van Dijk K, Rensen PC. Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells. Hepatology. (2015) 62:1710-22. (IF=11.06)

7. Draisma HH, Pool R, Kobl M, Jansen R, Petersen AK, Vaarhorst AA, Yet I, Haller T, Demirkan A, Esko T, Zhu G, Böhringer S, Beekman M, van Klinken JB, Römisch-Margl W, Prehn C, Adamski J, de Craen AJ, van Leeuwen EM, Amin N, Dharuri H, Westra HJ, Franke L, de Geus EJ, Hottenga JJ, Willemsen G, Henders AK, Montgomery GW, Nyholt DR, Whitfield JB, Penninx BW, Spector TD, Metspalu A, Eline Slagboom P, Willems van Dijk K, 't Hoen PA, Strauch K, Martin NG, van Ommen GJ, Illig T, Bell JT, Mangino M, Suhre K, McCarthy MI, Gieger C, Isaacs A, van Duijn CM, Boomsma DI. Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels. Nat Commun. (2015) 6:7208. (IF=10.74)

8. Demirkan A, Henneman P, Verhoeven A, Dharuri H, Amin N, van Klinken JB, Karssen LC, de Vries B, Meissner A, Göraler S, van den Maagdenberg AMJM, Deelder AM,  ’t Hoen PAC, van Duijn CM, Willems van Dijk K. Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses. PLoS Genet. (2015) Jan 8;11(1):e1004835. doi: 10.1371/journal.pgen.1004835 (IF=8.17)

9. Lips, M.A., van Klinken, J.B., van Harmelen, V., Dharuri, H.K., ’t Hoen, P.A, Laros, J.P., van Ommen, G.J., Janssen, I.M., van Ramshorst, B., van Wagensveld, B.A., Swank, D.J., van Dielen, F., Dane, A., Harms, A., Vreeken, R., Hankemeier, T., Smit, J.W., Pijl, H., Willems van Dijk, K. Roux and Y gastric bypass surgery, but not calorie restriction, reduces plasma branched chain amino acids in obese subjects independent of weight loss or the presence of type 2 diabetes mellitus. Diabetes Care. (2014) 37:3150-6. (IF=8.57) 

10. Wain LV, Verwoert GC, …., Henneman P, …., Wilems van Dijk K, …, Elliott P, van Duijn CM. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet. (2011); 43:1005-11. (IF=36.38)