Publications

1. Booij TH, Bange H, Leonhard WN, Yan K, Fokkelman M, Kunnen SJ, Dauwerse JG, Qin Y, van de Water B, van Westen GJP, Peters DJM, Price LS. High-Throughput Phenotypic Screening of Kinase Inhibitors to Identify Drug Targets for Polycystic Kidney Disease. SLAS Discov. 2017 Sep;22(8):974-984.

2. Kunnen,S.J., Leonhard,W.N., Semeins,C., Hawinkels,L.J.A.C., Poelma,C., Ten Dijke,P., Bakker,A., Hierck,B.P., Peters,D.J.M. (2017) Fluid shear stress-induced TGF-beta/ALK5 signaling in renal epithelial cells is modulated by MEK1/2. Cell Mol. Life Sci., 74, 2283-2298.

3. Calcagni,A., Kors,L., Verschuren,E., De Cegli,R., Zampelli,N., Nusco,E., Confalonieri,S., Bertalot,G., Pece,S., Settembre,C., et al. (2016) Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling. Elife., 5:e17047.

4. Leonhard,W.N., Happe,H., Peters,D.J. (2016) Variable Cyst Development in Autosomal Dominant Polycystic Kidney Disease: The Biologic Context. J. Am. Soc. Nephrol., 27, 3530-3538.

5. Leonhard,W.N., Kunnen,S.J., Plugge,A.J., Pasternack,A., Jianu,S.B., Veraar,K., El Bouazzaoui,F., Hoogaars,W.M., Ten Dijke,P., Breuning,M.H., et al. (2016) Inhibition of Activin Signaling Slows Progression of Polycystic Kidney Disease. J. Am. Soc. Nephrol., 27, 3589-3599.

6. Leonhard,W.N., Zandbergen,M., Veraar,K., van den Berg,S., van der Weerd,L., Breuning,M., De Heer,E., Peters,D.J. (2015) Scattered Deletion of PKD1 in Kidneys Causes a Cystic Snowball Effect and Recapitulates Polycystic Kidney Disease. J. Am. Soc. Nephrol., 26, 1322-1333.

7. Happe,H., Peters,D.J. (2014) Translational research in ADPKD: lessons from animal models. Nat. Rev. Nephrol., 10, 587-601.

8. Peyronnet,R., Sharif-Naeini,R., Folgering,J.H., Arhatte,M., Jodar,M., El Boustany,C., Gallian,C., Tauc,M., Duranton,C., Rubera,I., et al. (2012) Mechanoprotection by Polycystins against Apoptosis Is Mediated through the Opening of Stretch-Activated K2P Channels. Cell Reports, 1, 241-250.

9. Dauwerse,J.G., Dixon,J., Seland,S., Ruivenkamp,C.A., van Haeringen,A., Hoefsloot,L.H., Peters,D.J., Boers,A.C., Daumer-Haas,C., Maiwald,R., et al. (2011) Mutations in genes encoding subunits of RNA polymerases I and III cause Treacher Collins syndrome. Nat. Genet., 43, 20-22.

10. Leonhard,W.N., van der Wal,A., Novalic,Z., Kunnen,S.J., Gansevoort,R.T., Breuning,M.H., De Heer,E., Peters,D.J.M. (2011) Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: In vivo evidence from a Pkd1-deletion model. Am. J. Physiol Renal Physiol, 300, F1193-F1202.