Publications

1. de Jonge MM, Auguste A, van Wijk LM, Schouten PC, Meijers M, Ter Haar NT, Smit VTHBM, Nout RA, Glaire MA, Church DN, Vrieling H, Job B, Boursin Y, de Kroon CD, Rouleau E, Leary A, Vreeswijk MPG, Bosse T.  Frequent Homologous Recombination Deficiency in High-grade Endometrial Carcinomas. Clin Cancer Res. 2019 Feb 1;25(3):1087-1097. doi: 10.1158/1078-0432.CCR-18-1443.

2. Mesman RLS, Calléja FM, Hendriks G, Morolli B, Misovic B, Devilee P, van Asperen CJ, Vrieling H and MP Vreeswijk. The functional impact of variants of uncertain significance in BRCA2. Genetics in Medicine (2018) Jul 10. doi: 10.1038/s41436-018-0052-2

3. Shimelis H, Mesman RL, …, Vrieling H, Monteiro AN, Goldgar DE, Carreira A, Vreeswijk MP and FJ Couch, BRCA2 hypomorphic missense variants confer moderate risks of breast cancer. Cancer Res. (2017) Jun 1;77(11):2789-2799.

4. Boei JJ, Vermeulen S, Klein B, Hiemstra PS, Verhoosel RM, Jennen DG, Lahoz A, Gmuender H, Vrieling H. Xenobiotic metabolism in differentiated human bronchial epithelial cells. Arch Toxicol. (2017) May;91(5):2093-2105. doi: 10.1007/s00204-016-1868-7.

5. Hendriks G, Derr RS, Misovic B, Morolli B, Calléja FM, Vrieling H. The extended ToxTracker assay discriminates between induction of DNA damage, oxidative stress and protein misfolding. Toxicol Sci. (2016) Mar;150(1):190-203. doi: 10.1093/toxsci/kfv323.

6. Hendriks G, Morolli B, Calléja FM, Plomp A, Mesman RL, Meijers M, Sharan SK, Vreeswijk MP, Vrieling H. An Efficient Pipeline for the Generation and Functional Analysis of Human BRCA2 Variants of Uncertain Significance. Hum Mutat. (2014) Nov;35(11):1382-91.

7. Naipal KA, Verkaik NS, Ameziane N, van Deurzen CH, Ter Brugge P, Meijers M, Sieuwerts AM, Martens J, O'Connor MJ, Vrieling H, Hoeijmakers JH, Jonkers J, Kanaar R, de Winter J, Vreeswijk M, Jager A, van Gent DC. Functional ex vivo assay to select Homologous Recombination deficient breast tumors for PARP inhibitor treatment. Clin Cancer Res. (2014) Sep 15;20(18):4816-26.

8. Carreras Puigvert, J., von Stechow L, Siddappa R, Pines A, Bahjat M, Haazen LCJM, Olsen JV, Vrieling H, Meerman JHN, Mullenders LHF, van de Water B, Danen EHJ. Systems Biology Approach Identifies the Kinase Csnk1a1 as a Regulator of the DNA Damage Response in Embryonic Stem Cells. Sci. Signal (2013) Vol 6, Issue 259, p. ra5 

9. Hendriks G, Atallah M, Morolli B, Calléja F, Ras-Verloop N, Huijskens I, Raamsman M, van de Water B, Vrieling H. The ToxTracker assay: novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicals. Toxicol Sci. (2012) 125: 285-98. 

10. Pines A, Kelstrup CD, Vrouwe MG, Puigvert JC, Typas D, Misovic B, de Groot A, von Stechow L, van de Water B, Danen EH, Vrieling H, Mullenders LH, Olsen JV. Global phosphoproteome profiling reveals unanticipated networks responsive to cisplatin treatment of embryonic stem cells. Mol Cell Biol. (2011) 24: 4964-77.

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