- DNA double-strand break repair, BRCA1, homologous recombination
Sylvie Noordermeer received her PhD in 2012 from the University of Nijmegen with a thesis on aberrant ubiquitylation in leukemia. Funded by fellowships of the Dutch Cancer Foundation and the Canadian excellence in radiation research program, she performed postdoctoral research in the laboratory of prof. Daniel Durocher at the Lunenfeld-Tanenbaum Research Institute, Toronto. In 2017, Sylvie moved back to The Netherlands to join the lab of prof. Haico van Attikum at the LUMC. Sylvie’s postdoctoral research focussed on the regulation of pathway choice between non homologous end joining and homologous recombination in the repair of DNA double-strand breaks (Orthwein et al., Nature, 2015 and Noordermeer et al., Nature, 2018).
Sylvie started her own research group in 2019 as a junior group leader within the department of Human Genetics at the LUMC also holding a position as junior investigator with Oncode. Her group studies the individual role of multiple BRCA1-protein complexes in genome stability maintenance and how different BRCA1 cancer mutations affect these complexes and hence tumorigenesis.
Youtube movie Laboratory of DNA Recombination and Cancer (videographer Dave Guldemond)
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