Cluster headache research

Er wordt onderzoek gedaan naar het beloop van clusterhoofdpijn en naar voorspellende factoren. Ook wordt er onderzocht welke rol erfelijkheid speelt in het ontstaan van clusterhoofdpijn. Dit wordt gedaan binnen het LUCA-project. De naam staat voor Leiden University Cluster headache neuro-Analysis programme. In het LUMC wordt sinds jaren onderzoek gedaan naar het ontstaan van clusterhoofdpijn. Dit onderzoek wordt gedaan in samenwerking met een groot aantal neurologen en onderzoekers van verschillende afdelingen in Nederland.

The origin and clinical course of cluster headache have been studied in the LUMC for many years. Furthermore, we investigate the specific role of hereditary factors. This is done within the LUCA project: the Leiden University Cluster headache neuro-Analysis program. This project is a collaboration with a large number of neurologists and researchers from different departments in the Netherlands.

Current research into cluster headache
To learn more about the underlying mechanisms of cluster headache, individual information from many cluster headache patients is needed. To obtain this information, we are conducting extensive questionnaire research (in Dutch only).

More information on our questionnaires


It is important to identify genes that are involved in cluster headache. By finding these genes, we can increase our knowledge about the underlying mechanisms.

More information on our genetics research

For many cluster headache patients medication is an effective treatment . Unfortunately, for some patients with the chronic form of cluster headache the currently available medication is not sufficiently effective or has too many side effects. For this specific subgroup of patients, the efficacy and safety of neurostimulation are being studied.

More information on our neurostimulation research