News about our research

On this page we regularly share updates about our research. Also our research is frequently in the (local) media. On the Dutch version of this page you can find an overview (in Dutch only). At the bottom of the page there is a complete overview of all our news.

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The LUMC performs clinical research on headache, primarily focused on migraine and cluster headache. The headache research group LUMINA / LUCA consists of internationally renowned scientists and physicians from different departments of the LUMC. On this website extensive information about migraine, cluster headache and familial hemiplegic migraine (FHM) can be found. We also list our research into the causes and treatment of migraine and cluster headache.

There is a newsletter in Dutch for migraine ( LUMINA Nieuwsbrief )   and for cluster headache ( LUCA Nieuwsbrief ). These newsletters inform on our latest studies and findings.

Possibility for financial support
Would you like to support our research on migraine, cluster headache and other forms of headache? More information is listed on the 

Financial Support page.

Recent scientific publications
  • Harder AVE, Winsvold BS, Noordam R, Vijfhuizen LS, Børte S, Kogelman LJA, de Boer I, Tronvik E, Rosendaal FR, Willems van Dijk K, O'Connor E, Fourier C, Thomas LF, Kristoffersen ES; Cluster Headache Genetics Working Group, Fronczek R, Pozo-Rosich P, Jensen RH, Ferrari MD, Hansen TF, Zwart JA, Terwindt GM, van den Maagdenberg AMJM. Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache. Ann Neurol. 2021 Aug;90(2):203-216. doi: 10.1002/ana.26146. Epub 2021 Jul 14. PMID: 34180076; PMCID: PMC8362054.

  • Verhagen IE, Brandt RB, Kruitbosch CMA, MaassenVanDenBrink A, Fronczek R, Terwindt GM. symptoms of androgen deficiency in men with migraine or cluster headache: a cross-sectional cohort study. J Headache Pain. 2021 Oct 19;22(1):125. doi: 10.1186/s10194-021-01334-3. PMID: 34666669; PMCID: PMC8525012.

  • van Casteren DS, Verhagen IE, van der Arend BWH, van Zwet EW, MaassenVanDenBrink A, Terwindt GM. Comparing Perimenstrual and Nonperimenstrual Migraine Attacks Using an e-Diary. Neurology. 2021 Oct 26;97(17):e1661-e1671. doi: 10.1212/WNL.0000000000012723. Epub 2021 Sep 7. PMID: 34493613.

  • Brandt RB, Doesborg PGG, Meilof R, de Coo IF, Bartels E, Ferrari MD, Fronczek R. Repeated greater occipital nerve injections with corticosteroids in medically intractable chronic cluster headache: a retrospective study. Neurol Sci. 2021 Jun 22.
  • De Vries Lentsch S, Rubio-Beltrán E, MaassenVanDenBrink A. Changing levels of sex hormones and calcitonin gene-related peptide (CGRP) during a woman’s life: Implications for the efficacy and safety of novel antimigraine medications. Maturitas. 2021;145:73-77.
  • Ashina M, Terwindt GM, Al-Karagholi MA, de Boer I, Lee MJ, Hay DL, Schulte LH, Hadjikhani N, Sinclair AJ, Ashina H, Schwedt TJ, Goadsby PJ. Migraine: disease characterisation, biomarkers, and precision medicine. Lancet. 2021 Apr 17;397(10283):1496-1504.
  • Bos MM, Goulding NJ, Lee MA, Hofman A, Bot M, Pool R, Vijfhuizen LS, Zhang X, Li C, Mustafa R, Neville MJ, Li-Gao R, Trompet S, Beekman M, Biermasz NR, Boomsma DI, de Boer I, Christodoulides C, Dehghan A, van Dijk KW, Ford I, Ghanbari M, Heijmans BT, Ikram MA, Jukema JW, Mook-Kanamori DO, Karpe F, Luik AI, Lumey LH, van den Maagdenberg AMJM, Mooijaart SP, de Mutsert R, Penninx BWJH, Rensen PCN, Richmond RC, Rosendaal FR, Sattar N, Schoevers RA, Slagboom PE, Terwindt GM, Thesing CS, Wade KH, Wijsman CA, Willemsen G, Zwinderman AH, van Heemst D, Noordam R, Lawlor DA. Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses. BMC Med. 2021 Mar 18;19(1):69.
  • Verhagen IE, van Casteren DS, de Vries Lentsch S, Terwindt GM. Effect of lockdown during COVID-19 on migraine: A longitudinal cohort study. Cephalalgia. 2021 Jan 11:333102420981739. doi: 10.1177/0333102420981739. Epub ahead of print. PMID: 33430642.
  • van Casteren DS, Verhagen IE, Onderwater GL, MaassenVanDenBrink A, Terwindt GM. Sex differences in prevalence of migraine trigger factors: A cross-sectional study. Cephalalgia. 2021 May;41(6):643-648. doi: 10.1177/0333102420974362. Epub 2020 Nov 17. PMID: 33203218.

More scientific publications