Medically unexplained symptoms (MUS) are one of the focus area of the profile theme. Medically unexplained symptoms have a high prevalence and are among the most complex psychopathologies with huge impact for the patient and society. Bodily symptoms, such as acute pain, itch, tinnitus and fatigue, have a prevalence of up to 50% in general practice and frequently remain unexplained. These acute symptoms can ultimately develop into clinical manifestations of chronically unexplained symptoms and somatoform disorders. For these patients, effective pharmacological treatments are largely unavailable and treatment effects vary highly between patients, resulting in substantial costs for the patients and society.
The overall aim of the projects in the profile area’s is to identify patients at risk for medically unexplained symptoms at an early stage of their condition and develop innovative treatments for these patients to unravel the mechanisms of change in various somatoform symptoms and disorders in network structures.