Biological Clocks

The biological clocks and circadian rhythms play an important role in many physiological processes, including sleep, cognitive performance, blood pressure, temperature control, hormone levels and sensitivity to medication.

The following LCTN programmes participate:

Circadian Rhythm and Sleep

Principal investigators: Prof.dr J.H. Meijer, Dr S. Michel, Dr T. deBoer, Dr J. Rohling, Dr E. Vreugdenhil | Molecular Cell Biology

A key question in translational neuroscience is how life-style and age induced deterioration of 24-hour rhythms can lead to metabolic and sleep disorders, depression, and neurodegenerative diseases. Twenty-four hour rhythms are profoundly present in all physiological systems to adapt to recurrent environmental changes, and are deeply embedded in biology. The central pacemaker driving these rhythms, the suprachiasmatic nucleus, is located in the evolutionary old part of the brain, at the base of the hypothalamus.

The aim of the program is to understand the physiological bases of circadian rhythms, and to translate these findings in new strategies for treatment.

Read more: Circadian rhytm and sleep