prof. dr. H. (Hein) Putter

Hoogleraar, wetenschappelijk staflid


  • medische statistiek


I received my Ph.D. in mathematical statistics from the University of Leiden in 1994, under the supervision of Willem van Zwet, on the topic of resampling methods. After post-doc positions in the Department of Mathematics of the University of Amsterdam and the Free University Amsterdam, and at the Statistical Laboratory of the University of Cambridge, I turned to medical statistics in 1998, working for the HIV Monitoring Fund and the International Antiviral Therapy Evaluation Center (IATEC), based at the Amsterdam Medical Center. In 2000, I was appointed assistant professor in the Department of Medical Statistics and Bioinformatics of the Leiden University Medical Center.

My research interests include: statistical genetics, dynamical models in HIV and survival analysis—in particular competing risks and multi-state models. I collaborate closely with the Department of Surgery and the Department of Oncology of the LUMC, and with international organizations like the European Organisation for the Research and Treatment of Cancer (EORTC) and the European Group for Blood and Marrow Transplantation (EBMT). I serve as associate editor of Statistics and Probability Letters and Statistics in Medicine, and was guest editor of special issues of Biometrical Journal and Journal of Statistical Software. I was one of the initiators of the IBS Channel Network.

In 2010, I was appointed full professor in the Department of Medical Statistics and Bioinformatics of the LUMC. Together with Hans van Houwelingen I wrote a book “Dynamic Prediction in Clinical Survival Analysis”, which will appear in December 2011 at Chapman & Hall.


My most important research area is survival analysis. Within this field, my main research interests are competing risks and multi-state models, dynamic prediction, and frailties.

The topics competing risks / multi-state models and dynamic prediction are closely related. 

Other (former) research interests are resampling methods, spatial statistics (kriging), statistical genetics, and mixed-effects models.


Click here for a list of publications from Pubmed. Note: these do not include my mathematical publications, they do include publications from I believe two other H Putters working in dentistry (before 2000) and in chemistry (2006).

My methodological papers:

Fiocco M, Stijnen T, Putter H (2011). Meta-analysis of time-to-event outcomes using a hazard-based approach: Comparison with other models, robustness and meta-regression. Comp Statist Data Anal. In Press, doi:10.1016/j.csda.2011.05.009.

de Wreede LC, Fiocco M, Putter H (2011). mstate: An R package for the analysis of competing risks and multi-state models. J Statist Softw 38: 7.

Commenges D, Jolly D, Drylewicz J, Putter H, Thiébaut R (2011). Inference in HIV dynamics models via hierarchical likelihood. Comp Statist Data Anal. 55: 446-456.

de Wreede LC, Fiocco M, Putter H (2010). The mstate package for estimation and prediction in non- and semi-parametric multi-state and competing risks models. Comput Methods Programs Biomed.99: 261-274.

Nicolaie MA, van Houwelingen HC, Putter H (2010). Vertical modeling: a pattern mixture approach for competing risks modeling. Stat Med. 29: 1190-1205.

Putter H, Fiocco M, Stijnen T (2010). Meta-analysis of diagnostic test accuracy studies with multiple thresholds using survival methods. Biom J.52: 95-110.

Fiocco M, Putter H, van Houwelingen JC (2009). Meta-analysis of pairs of survival curves under heterogeneity: a Poisson correlated gamma-frailty approach. Stat Med.28: 3782-3797.

Uh HW, Houwing-Duistermaat JJ, Putter H, van Houwelingen HC (2009). Assessment of global phase uncertainty in case-control studies. BMC Genet.10:54.

Fiocco M, Putter H, Van Houwelingen JC (2009). A new serially correlated gamma-frailty process for longitudinal count data. Biostatistics10: 245-257.

van Houwelingen HC, Putter H (2008). Dynamic predicting by landmarking as an alternative for multi-state modeling: an application to acute lymphoid leukemia data. Lifetime Data Anal.14: 447-463.

Putter H, Vos T, de Haes H, van Houwelingen H (2008). Joint analysis of multiple longitudinal outcomes: Application of a latent class model. Stat Med.27: 6228-6249.

Lebrec JJ, Putter H, Houwing-Duistermaat JJ, van Houwelingen HC (2008). Influence of genotyping error in linkage mapping for complex traits--an analytic study. BMC Genet.9: 57.

Uh HW, Mertens BJ, Jan van der Wijk H, Putter H, van Houwelingen HC, Houwing-Duistermaat JJ (2007). Model selection based on logistic regression in a highly correlated candidate gene region. BMC Proc. 1 Suppl 1: S114.

Fiocco M, Putter H, van Houwelingen HC (2008). Reduced-rank proportional hazards regression and simulation-based prediction for multi-state models. Stat Med. 27: 4340-4358.

Putter H, Meulenbelt I, van Houwelingen JC (2007). Relative efficiency of haplotype frequency estimation in sibships and nuclear families compared to unrelated individuals. Hum Hered. 64: 52-62.

Putter H, Fiocco M, Geskus RB (2007). Tutorial in biostatistics: competing risks and multi-state models. Stat Med. 26: 2389-2430.

Putter H, van der Hage J, de Bock GH, Elgalta R, van de Velde CJ (2006). Estimation and prediction in a multi-state model for breast cancer. Biom J. 48: 366-380.

Fiocco M, Putter H, van de Velde CJH, van Houwelingen JC (2006). Reduced rank proportional hazards model for competing risks: An application to a breast cancer trial. J Statist Plann Inf 136: 1655-1668.

Houwing-Duistermaat JJ, Uh HW, Lebrec JJ, Putter H, Hsu L (2005). Modeling the effect of an associated single-nucleotide polymorphism in linkage studies. BMC Genet. 6: S46.

Uh HW, Houwing-Duistermaat JJ, Putter H, van Houwelingen HC (2005). How to quantify information loss due to phase ambiguity in haplotype case-control studies. BMC Genet. 6: S108.

Putter H, Houwing-Duistermaat JJ, Nagelkerke NJ (2005). Combining evidence for association from transmission disequilibrium and case-control studies using single-nucleotide polymorphisms. BMC Genet. 6: S106.

Lebrec J, Putter H, van Houwelingen JC (2006). Potential bias in Generalized Estimating Equations linkage methods under incomplete information. Genet Epidemiol. 30: 94-100.

Putter H, Sasako M, Hartgrink HH, van de Velde CJ, van Houwelingen JC (2005). Long-term survival with non-proportional hazards: results from the Dutch Gastric Cancer Trial. Stat Med. 24: 2807-2821.

Putter H, Marijnen CA, Kranenbarg EK, van de Velde CJ, Stiggelbout AM (2005). Missing forms and dropout in the TME quality of life substudy. Qual Life Res. 14: 857-865.

Fiocco M, Putter H, Van Houwelingen JC (2005). Reduced rank proportional hazards model for competing risks. Biostatistics. 6: 465-478.

Klaassen CAJ, Putter H (2005). Efficient estimation of Banach parameters in semiparametric models. Ann Statist33: 307-346.

Wintrebert CMA, Putter H, Zwinderman AH, van Houwelingen JC (2004). Centre-effect on survival after bone marrow transplantation: Application of time-dependent frailty models. Biom J. 46: 512-525.

Lebrec J, Putter H, Houwelingen JC (2004). Score test for detecting linkage to complex traits in selected samples. Genet Epidemiol. 27: 97-108.

Putter H, Lebrec J, van Houwelingen HC (2003). Selection strategies for linkage studies using twins. Twin Res. 6: 377-382.

Putter H, Heisterkamp SH, Lange JMA, de Wolf F (2002). A Bayesian approach to parameter estimation in HIV dynamical models. Stat Med.  21: 2199-2214.

Putter H, Sandkuijl LA, van Houwelingen JC (2002). Score test for detecting linkage to quantitative traits. Genet Epidemiol.22: 345-355.

Putter H, Young GA (2002). On the effect of covariance function estimation on the accuracy of kriging predictors. Bernoulli7: 421-438.

Bloznelis M, Putter H (2002). Second-order and bootstrap approximation to Student's t-statistic. Th Prob Appl. 47: 300-307.

Wehrens R, Putter H, Buydens LMC (2000). The bootstrap: a tutorial. Chemometr Intell Lab Syst.  54: 35-52.

Putter H, van Zwet WR (1998). Empirical Edgeworth expansions for symmetric statistics. Ann Statist. 26: 1540-1569.

Putter H, van Zwet WR (1997). On a set of the first category. Festschrift for Lucien Le Cam, 315-323, Springer, New York.

Putter H, van Zwet WR (1996). Resampling: Consistency of substitution estimators with applications to the bootstrap. Ann Statist. 24: 2297-2318.

Putter H (1994). Consistency of Resampling Methods. PhD Thesis.


Leids Universitair Medisch Centrum
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