Chromatin and DNA repair

The DNA damage response (DDR) is a network of cellular pathways that sense, signal and repair DNA lesions. Defects in the DDR can result in mutations and genome instability, and can lead to diseases such as cancer, immunodeficiency and neurodegenerative disorders.

We employ a cross-disciplinary systems biology-based approach that encompasses genetics, proteomics, microscopy and bioinformatics in yeast, mouse and human/patient cells to identify the proteins that constitute DDR pathways, and study their impact on genome stability maintenance and human disease.

Our research focuses on the following topics:

  • Systems analysis of the DNA damage response
  • Chromatin-modifying factors in DNA repair and human disease
  • Ubiquitinating and de-ubiquitinating enzymes in DNA repair and cancer
  • Functional analysis of genetic variants in putative breast cancer susceptibility genes

Our Team

Prof.dr. Haico van Attikum         
Principal Investigator / Professor Chromatin and DNA-repair

Rick A.C.M. Boonen                     
Researcher

Bert W. van de Kooij
Researcher

Magdalena B. Krawitowska-Rother         
Researcher

Prof.dr. Haico van Attikum         
Principal Investigator / Professor Chromatin and DNA-repair

Rick A.C.M. Boonen                     
Researcher

Bert W. van de Kooij
Researcher

Magdalena B. Krawitowska-Rother         
Researcher

Fenna J. van der Wal     
PhD student

Sophie C. van der Horst
PhD student

Jolanthe Lingeman         
PhD student

Anton J.L. de Groot                       
Research technician

Sabine C. Knaup                             
Research technician

Kees Vreeken                   
Research technician

Wouter W. Wiegant      
Research technician